All chemicals were purchased from commercial sources as noted below and used as received. NMR spectra were recorded on a Varian Inova 500 (500 MHz for 1H and 125 MHz for 13C) instrument in CD3OD and were recorded at ambient temperatures. Chemical shifts are reported in units of parts per million (ppm). 1H NMR were calibrated using the residual protio-solvent as a standard. 13C NMR spectra are calibrated using the deutero-solvent as a standard. High-resolution mass spectra (HRMS) was obtained on a Bruker micrOTOFQ-II mass spectrometer.
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o-AMSA hydrochloride was prepared from 9-chloroacridine (Aldrich) and N-(4-amino-2-methoxyphenyl)methanesulfonamide (ChemBridge) according to a literature procedure41 (link). 1H NMR (500 MHz, CD3OD): δ 8.23 (ddd, J = 8.8, 1.3, 0.6 Hz, 2H), 8.03 – 7.98 (m, 2H), 7.95 (ddd, J = 8.6, 1.3, 0.6 Hz, 2H), 7.55 (d, J = 8.4 Hz, 1H), 7.48 (ddd, J = 8.8, 6.7, 1.3 Hz, 2H), 7.17 (d, J = 2.3 Hz, 1H), 7.02 (dd, J = 8.4, 2.3 Hz, 1H), 3.84 (s, 3H), 3.02 (s, 3H); 13C NMR (126 MHz, CD3OD): δ 157.3, 154.1, 141.8, 139.7, 136.9, 127.6, 126.8, 125.9, 125.4, 120.2, 118.1, 115.2, 109.5, 56.8, 39.9; HRMS (m/z): [M]+ calcd. for [C21H20N3O3S]+, 394.1220; found, 394.1224. see Supplementary Fig. 12
N 4 amino 2 methoxyphenyl methanesulfonamide
Manufactured by ChemBridge
N-(4-amino-2-methoxyphenyl)methanesulfonamide is a chemical compound used in laboratories as a reagent or intermediate. It consists of a methoxyphenyl group with an amino substituent and a methanesulfonamide functional group. This product is typically used for various chemical transformations and analyses, but a detailed description of its core function or intended use cannot be provided while maintaining an unbiased and factual approach.
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2 protocols using n 4 amino 2 methoxyphenyl methanesulfonamide
1
Synthesis and Characterization of o-AMSA
2
Synthesis and Characterization of o-AMSA Hydrochloride
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All chemicals were purchased from commercial sources as noted below and used as received. NMR spectra were recorded on a Varian Inova 500 (500 MHz for 1H and 125 MHz for 13C) instrument in CD3OD and were recorded at ambient temperatures. Chemical shifts are reported in units of parts per million (ppm). 1H NMR were calibrated using the residual protio-solvent as a standard. 13C NMR spectra are calibrated using the deutero-solvent as a standard. High-resolution mass spectra (HRMS) was obtained on a Bruker micrOTOFQ-II mass spectrometer.
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o-AMSA hydrochloride was prepared from 9-chloroacridine (Aldrich) and N-(4-amino-2-methoxyphenyl)methanesulfonamide (ChemBridge) according to a literature procedure41 (link). 1H NMR (500 MHz, CD3OD): δ 8.23 (ddd, J = 8.8, 1.3, 0.6 Hz, 2H), 8.03 – 7.98 (m, 2H), 7.95 (ddd, J = 8.6, 1.3, 0.6 Hz, 2H), 7.55 (d, J = 8.4 Hz, 1H), 7.48 (ddd, J = 8.8, 6.7, 1.3 Hz, 2H), 7.17 (d, J = 2.3 Hz, 1H), 7.02 (dd, J = 8.4, 2.3 Hz, 1H), 3.84 (s, 3H), 3.02 (s, 3H); 13C NMR (126 MHz, CD3OD): δ 157.3, 154.1, 141.8, 139.7, 136.9, 127.6, 126.8, 125.9, 125.4, 120.2, 118.1, 115.2, 109.5, 56.8, 39.9; HRMS (m/z): [M]+ calcd. for [C21H20N3O3S]+, 394.1220; found, 394.1224. see Supplementary Fig. 12
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