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Tbk1 ikkε in 2

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TBK1/IKKε‐IN‐2 is a potent and selective inhibitor of the protein kinases TBK1 and IKKε. It is used as a research tool to study the functions of these enzymes in cellular signaling pathways.

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Lab products found in correlation

Etoposide, by Selleck Chemicals (1 mentions) Diabzi, by Selleck Chemicals (1 mentions) Ru 521, by MedChemExpress (1 mentions) Stattic, by Selleck Chemicals (1 mentions) Tg003, by Selleck Chemicals (1 mentions) Treprostinil, by Bio-Techne (1 mentions) Amlexanox, by Bio-Techne (1 mentions)

2 protocols using tbk1 ikkε in 2

1

Signaling Pathway Modulation in Cell Lines

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G150 (cat. no. HY‐128583; MedChemExpress, NJ, USA); H‐151 (cat. no. S6652, Selleck, Houston, TX, USA); TBK1/IKKε‐IN‐2 (cat. no. S0425, Selleck); Stattic (cat. no. S7024; Selleck); diABZI (cat. no. S8796; Selleck); G140 (cat. no. HY‐133916; MedChemExpress); RU.521 (cat. no. S6841; Selleck); TG003 (cat. no. S7320; Selleck), DOX (cat. no. S1208, Selleck); etoposide (cat. no. HY‐13629, MedChemExpress).
Lu X., Wang S., Hua X., Chen X., Zhan M., Hu Q., Cao L., Wu Z., Zhang W., Zuo X., Gui R., Fan L., Li J., Shi W, & Jin H. (2023). Targeting the cGAS‐STING Pathway Inhibits Peripheral T‐cell Lymphoma Progression and Enhances the Chemotherapeutic Efficacy. Advanced Science, 11(10), 2306092.
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2

Inhibition of TBK1/IKKε Signaling Pathway

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The following chemical inhibitors were used: treprostinil (Compound CID: 91617675) a potent prostacyclin (PGI2) analog (Tocris), inhibitors of TBK1/IKKε: Amlexanox (Compound CID: 2161) (Tocris), TBK1/IKKε‐IN‐1(compound I) (CI) (Compound CID: 124156234) (Selleckchem), and TBK1/IKKε‐IN‐2 (compound II) (CII) (Selleckchem). The chemical stocks were prepared using DMSO as the solvent and all the experiments used DMSO as a control.
Aravamudhan A., Dieffenbach P.B., Choi K.M., Link P.A., Meridew J.A., Haak A.J., Fredenburgh L.E, & Tschumperlin D.J. (2024). Non‐canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells. Physiological Reports, 12(7), e15999.
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