Skyra 3 tesla mri scanner

T2 weighted MRI (T2w MRI) and diffusion weighted imaging (DWI) were performed to assess structural changes and tissue cellularity, respectively, in a subset of patients with confirmed hepatic metastases. All MRI scans were acquired on a Siemens Skyra 3 Tesla MRI scanner (Siemens Healthineers, Malvern, PA, USA) equipped with a 32-channel phased-array body coil. The entire liver was included in the field of view (38 × 38 cm²). The MRI protocol consisted of a conventional axial fast spin echo T2 weighted imaging (FSE T2WI) sequence, followed by an axial spin echo echoplanar imaging (SE-EPI) DWI sequence with multiple b-values (0, 100, 200, 600, 800, 1000, 1200 s/mm²). Total tumor burden (reported in cm³) was calculated from the sequential T2w MRI and compared with the apparent diffusion coefficient (ADC) values from DWI as an assessment of tumor cellularity and apoptosis in order to determine its function as a potential biomarker of early treatment response [17 (link),18 (link)]. DWI and T2w MRI were performed prior to treatment initiation, C1D7 (after single-agent lead-in), and C2D7 (after combination treatment) (Figure 1).

Scanning was conducted between August 2013 and July 2017 at Monash Biomedical Imaging (Victoria, Australia). Images were acquired using a Siemens Skyra 3-Tesla MRI scanner with a 32-channel head coil. High resolution T1-weighted structural MPRAGE images (time echo [TE] = 2.07 ms, time repetition [TR] = 2,300 ms, FOV = 256 mm, flip angle = 9°, thickness = 1 mm isotropic, sagittal slices) were acquired prior to functional imaging to enable activation localization and for spatial normalization. Functional images were acquired using a gradient-echo pulse sequence (TE = 30 ms, TR = 2,460 ms, FOV = 190 mm, flip angle = 90°, 44 contiguous transversal slices of 3.0 mm thickness). The error awareness task was presented using E-Prime software (version 2.0; Psychology Software Tools) on a Cambridge 32-inch BOLD screen, which was reflected onto a mirror visor positioned in the radio frequency head coil. Participants responded to each stimulus using their right hand, entering their responses using 2 buttons on a 4-button MR-compatible response pad (Fiber-Optic response pads; Current Designs).