Solvents and chemical reagents

Solvents and chemical reagents were purchased from Sigma (Oakville, ON, Canada) and Thermo Scientific (Waltham, MA, USA). Cholesterol, 1,2-dioleyloxy-3-dimethylaminopropane (DODMA), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(lissamine rhodamine B sulfonyl) (ammonium salt) (rhodamine-PE) were obtained from Avanti Polar Lipids (Alabaster, AL, USA). (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (MC3) and 1,2-dioleoyl-3-dimethylammonium-propane (DODAP) were purchased from Nanosoft Polymers (Winstom-Salem, NC, USA). Poly-L-Arginine (5000–15,000 Da) was obtained from Sigma (Oakville, ON, Canada). Hyaluronic acid (60 KDa) was obtained from Lifecore Biomedical Inc. (Chaska, MN, USA). Oligonucleotides were obtained from Horizon Discovery (Waterbeach, UK). siRNAs were custom-made with the following sequences: scramble siRNA (siCTL, 5′-UAGCGACUAAACACAUCAAUU-3′), scramble siRNA Cyanine-3 (siRNA-Cy3, 5′-Cy3-UAGCGACUAAACACAUCAAUU-3′), and siRNA Luciferase (siLuc, 5’-GGUCUGAGCUCCUUGAUAAUU-3′). Hoechst 33,342 was purchased from Cayman Chemical (Ann Arbor, MI, USA).

Solvents and chemical reagents were purchased from Sigma-Aldrich (San Luis, MO, USA), abcr GmbH (Karlsruhe, Germany), Thermo Fisher Scientific (Waltham, MA, USA), Scharlab (Sentmenat, Barcelona, Spain), FluoroChem (Hadfield, UK) and VWR (Radnor, PA, USA).
Oligonucleotides were purchased from Integrated DNA Technologies (IDT, Coralville, IA, USA).
Roswell Park Memorial Institute (RPMI) medium, streptomycin–penicillin (100X), fetal bovine serum (FBS), l-glutamine (100X), trypsin (10X), phosphate-buffered saline (PBS) and cell culture plasticware were purchased from VWR. Thiazolyl blue tetrazolium bromide, propidium iodide (PI), Hoechst 33342 and dimethyl sulfoxide (DMSO) were obtained from Sigma-Aldrich; and Lipofectamine 2000, RNase H and Opti-MEM from Thermo Fisher Scientific. c-Met and anti-rabbit IgG Alexa Fluor 488 antibodies were purchased from Cell Signaling Technology (Danvers, MA, USA).

Solvents and chemical reagents were purchased from Sigma Aldrich if not specifically mentioned otherwise. Commercial enzymes T4 ligase, exonuclease I, exonuclease III, Fpg, APE1, hAAG and UDG were purchased from New England Biolabs and hOGG1 was purchased from R&D system.