Inveon multiple modality pet ct scanner

Manufactured by Siemens

Sourced in United States

The Inveon Multiple Modality PET/CT scanner is a medical imaging system designed for preclinical research. It combines positron emission tomography (PET) and computed tomography (CT) technologies to provide high-resolution, multimodal imaging capabilities.

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Lab products found in correlation

Pmod software, by PMOD Technologies (2 mentions) Analyze 12, by AnalyzeDirect (1 mentions) Breeze2, by Bayer (1 mentions) Wizard 2480 gamma counter, by PerkinElmer (1 mentions) Sodium bicarbonate, by Merck Group (1 mentions) Hplc grade acetonitrile, by Merck Group (1 mentions) Trifluoroacetic acid tfa, by Merck Group (1 mentions)

5 protocols using inveon multiple modality pet ct scanner

PET Imaging of B^18F_4 in Mice

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For PET imaging, mice received 300 μCi of B¹⁸F₄ 45 min prior to image acquisition. PET/CT imaging was performed on a small animal Inveon multiple modality PET/CT scanner (Siemens). CT was performed at 80 kEv, 500 μA, with 250 ms/projection, 180 projections, and bin 4; the effective pixel size was 94.59 μm. PET was performed using 10-min acquisition, OSEM2D reconstruction with Fourier rebinning, and four iterations. Co-registered images were rendered and visualized using the PMOD software version 3.504.

Concilio S.C., Suksanpaisan L., Pham L., Peng K.W, & Russell S.J. (2020). Improved Noninvasive In Vivo Tracking of AAV-9 Gene Therapy Using the Perchlorate-Resistant Sodium Iodide Symporter from Minke Whale. Molecular Therapy, 29(1), 236-243.

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Quantifying Nerve Vasculature with Micro-CT

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With a micro-CT (Inveon Multiple Modality PET/CT scanner, Siemens Medical Solutions USA, Inc., Knoxville, TN), a CT scan was obtained from the nerve samples with an effective pixel size of 9.91μm. As the microfil was more radiopaque than the rest of the nerve, the volume of the total nerve and the volume of the vasculature could be measured with Analyze 12.0 software (AnalyzeDirect, Inc., Overland Park, KS, USA). Eventually, vessel/nerve volume ratios were calculated for each scan.^{42 (link)}

Mathot F., Rbia N., Bishop A.T., Hovius S.E, & Shin A.Y. (2020). Adipose mesenchymal stem cells seeded onto a decellularized nerve allograft enhances angiogenesis in a rat sciatic nerve defect model. Microsurgery, 40(5), 585-592.

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Radiolabeling and Characterization of 68Ga-NOTA Conjugates

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Sodium
bicarbonate, acetonitrile
(HPLC grade), and trifluoroacetic acid (TFA, 99%) were purchased from
Sigma-Aldrich (St. Louis, MO). The i-TLC paper was purchased from
Agilent Technologies (Palo Alto, CA). The labeling precursor p-SCN-Bn-NOTA
(B-605, ≥94%) was purchased from Macrocyclics, Plano, TX. The
radioactive samples were counted using a Wizard 2480 gamma counter
(PerkinElmer, Waltham, MA). The radioactivity readings were recorded
using a CRC dose calibrator (416 setting for ⁶⁸Ga, CRC-55tPET,
Capintec, Ramsey, NJ). The MALDI-TOF analysis was performed at the
Mass Spectrometry Facility, School of Chemical Sciences, University
of Illinois at Urbana-Champaign. The radio-iTLC was performed on an
Eckert & Ziegler scanner (Valencia, CA). The glucose level was
measured using a handheld glucometer with Bayer Breeze 2, Whippany,
NJ. The microPET/CT was performed on an Inveon Multiple Modality PET/CT
scanner by Siemens Medical Solutions, Inc. Knoxville, TN. Autoradiography
was performed using a Cyclone Plus Storage Phosphor System by PerkinElmer
Corporation, Waltham, MA.

Taubel J.C., Nelson N.R., Bansal A., Curran G.L., Wang L., Wang Z., Berg H.M., Vernon C.J., Min H.K., Larson N.B., DeGrado T.R., Kandimalla K.K., Lowe V.J, & Pandey M.K. (2022). Design, Synthesis, and Preliminary Evaluation of [68Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer’s Disease Mouse Model. Bioconjugate Chemistry, 33(5), 892-906.

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PET/CT Imaging of 18F-TFB in Mice

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Imaging was performed in the Mayo Clinic Small Animal Imaging Core using an Inveon Multiple Modality PET/CT scanner (Siemens Medical Solutions, Knoxville, TN, USA). ¹⁸F-TFB for PET/CT imaging was produced as previously described (33 (link)). Forty-five minutes to one hour prior to PET imaging, 9.25 MBq of ¹⁸F-TFB was delivered to the mice via intravenous injection. CT image acquisition was performed in 5 minutes with 360-degree rotation and 180 projections at 500 µA, 80 keV and 200 ms exposure. PET Image acquisition began approximately 45 minutes following isotope injection with total acquisition time of 20 minutes.
Co-registered images were rendered and visualized using the PMOD software (PMOD Technologies Ltd., Switzerland). To calculate standardized uptake value (SUV), the volume of interest (VOI) was determined by the PMOD software. Then, SUV was calculated using the formula as below.
The use and handling of radiotracers were approved by the Institutional Biosafety Committee (IBC HIP00000252).

Sakemura R., Bansal A., Siegler E.L., Hefazi M., Yang N., Khadka R.H., Newsom A.N., Hansen M.J., Cox M.J., Roman C.M., Schick K.J., Can I., Tapper E.E., Nevala W.K., Adada M.M., Bezerra E.D., Kankeu Fonkoua L.A., Horvei P., Ruff M.W., Parikh S.A., Pandey M.K., DeGrado T.R., Suksanpaisan L., Kay N.E., Peng K.W., Russell S.J, & Kenderian S.S. (2021). Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-Cell Expansion, Trafficking, and Toxicity. Cancer immunology research, 9(9), 1035-1046.

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Quantifying Cell-Specific [18F]-TFB Uptake

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Increasing numbers of A549-hNIS-Neo/Fluc-Puro cells were mixed with parental A549 cells in microcentrifuge tubes, such that each tube contained a total of 1 × 10⁶ cells. The cells were incubated at 37 ^oC for 30 min with 2 μCi [¹⁸F]-TFB in 1 ml of HEPES/HBSS. The cells were centrifuged and washed once with cold HEPES/HBSS. The final cell pellets were immediately imaged on a small animal Inveon Multiple Modality PET/CT scanner (Siemens Medical Solutions USA, Inc., Malvern, PA, USA). CT was performed at 60 kEv, 500 μA, with 400 ms/projection, 180 projections, and bin 4. The effective pixel size was 94.26 μm. PET was performed at 10 min acquisition, 3DRP reconstruction with Colsher filter, and 0.5 cutoff. Co-registered images were rendered and visualized using the PMOD software (PMOD Technologies, Zurich, Switzerland). Values represent the mean (± standard deviation) [¹⁸F]-TFB uptake in μCi.

Vandergaast R., Khongwichit S., Jiang H., DeGrado T.R., Peng K.W., Smith D.R., Russell S.J, & Suksanpaisan L. (2019). Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging. Cancer Gene Therapy, 27(3), 179-188.

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