Skyscan dataviewer

Manufactured by Bruker

Sourced in Germany, Belgium

The SkyScan DataViewer is a software tool used to visualize and analyze data obtained from Bruker's SkyScan line of micro-computed tomography (micro-CT) systems. It provides users with the ability to view, navigate, and manipulate three-dimensional image data captured by the micro-CT instruments.

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Lab products found in correlation

Skyscan ctan, by Bruker (2 mentions) Skyscan 1176, by Bruker (2 mentions) Nrecon program, by Bruker (1 mentions) Xtreme system, by Bruker (1 mentions) Skyscan 1276, by Bruker (1 mentions) Ge explore locus sp micro ct, by GE Healthcare (1 mentions) Skyscan nrecon program, by Bruker (1 mentions)

5 protocols using skyscan dataviewer

Micro-CT Analysis of Bone and Callus Mineralization

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For evaluation of the bone and mineralized callus, all samples were scanned using micro-computed tomography (micro-CT) (SkyScan 1176 compact X-ray MicroCT scanner; Bruker, Brussels, Belgium) with the beam set at 90 kV and 270 μA and reconstructed at 18 μm isotropic resolution (NRecon Program; Bruker).
As in previous publications, the mineralized tissues were classified as bone or callus depending on its density relative to that of the undisturbed cortical bone45 (link). A callus was defined as bone having a density of 35–70% of the maximum density of the undisturbed cortical bone. Bone was defined as having a density of >70% of the maximum density. A 10-mm length of a cylindrical volume of interest was selected for analyzing the fracture site. It was centered at the midpoint of the fracture in the longitudinal view.
Mineralized callus volume and density and bone volume and density were determined and analyzed to compare the differences in mineralization of the two groups. SkyScan Dataviewer and SkyScan CTan (Bruker) were used for these evaluations.

Xue Z., Xu H., Ding H., Qin H, & An Z. (2016). Comparison of the effect on bone healing process of different implants used in minimally invasive plate osteosynthesis: limited contact dynamic compression plate versus locking compression plate. Scientific Reports, 6, 37902.

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Quantifying Muscle and Fat in Mice

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At ages 13–14 months, wild-type and Gfpt1 exon 9 KO mice (n = 5 mice each) were sacrificed and transverse μCT images were taken with a Skyscan 1176 X-ray-computed microtomography scanner (Bruker) and a 0.5-mm aluminum filter. We reconstructed three axial slices at the L4/5 disc level, the femoral lesser trochanter level, and the maximum calf-circumference level with SkyScan DataViewer (Bruker). Paravertebral muscles and fat tissues were manually identified and were quantified using the ImageJ program (http://imagej.nih.gov/ij/).

Farshadyeganeh P., Nazim M., Zhang R., Ohkawara B., Nakajima K., Rahman M.A., Nasrin F., Ito M., Takeda J.I., Ohe K., Miyasaka Y., Ohno T., Masuda A, & Ohno K. (2023). Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction. iScience, 26(10), 107746.

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Micro-CT Analysis of Femoral Bone Properties

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Imaging operations were conducted at MDACC Small Animal Imaging Facility. Radiography of mice was conducted using the Bruker Xtreme system. Micro-CT scanning was performed using the Bruker SkyScan 1276 micro-CT system (Bruker BioSpin Corporation). The scanning parameters are: resolution: 13 μm; pixel size: 13.083 μm; voltage: 55 kV; current: 200 μA; rotation step (deg): 0.400; duration: 11 min; exposure time: 500 ms; filter: 0.25 mm Al; matrix: 2016 ×1344. The femurs of 6-month-old Col1a1^fspKO mice and wild-type (WT) littermates were scanned and measured for the bone material properties. The trabecular bone parameters were measured in the distal metaphysis of the femurs, while the cortical bone parameters were measured at the femur mid-diaphysis. The detected bone parameters included trabecular or cortical bone mineral density (BMD), bone volume/total volume (BV/TV), trabecular or cortical bone surface area/bone volume (BS/BV), trabecular thickness (Tb.Th), trabecular number (Tb.N), cortical bone total area (Tt.Ar), cortical bone area (Ct.Ar), cortical bone marrow area (Ma.Ar),), cortical bone area/total area (Ct.Ar/Tt.Ar), and cortical thickness (Ct.Th). The analysis was conducted using Bruker SkyScan DataViewer software version 1.5.0.

Chen Y., Yang S., Lovisa S., Ambrose C.G., McAndrews K.M., Sugimoto H, & Kalluri R. (2021). Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta. Nature Communications, 12, 7199.

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Micro-CT Analysis of Damaged Bone

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Damaged bone around the particles was detected using the GE Explore Locus SP Micro-CT (GE Healthcare, Chicago, IL, USA), and 3D images were reconstructed. The bone volume fraction (bone volume/total volume) and trabecular pattern factor were determined using SkyScan DataViewer and CTAn software (Bruker, Karlsruhe, Germany). The region of interest was from the growth plate to the trabecular bone under the growth plate with a thickness of 200 micro-CT layers [2 (link)].

Meng X., Zhang W., Lyu Z., Long T, & Wang Y. (2022). ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis. Journal of Orthopaedic Translation, 34, 1-10.

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Micro-CT Analysis of Fracture Callus

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Bone and mineralized callus structure and density were evaluated by Micro-CT. A SkyScan 1176 compact X-ray MicroCT scanner (Bruker, Belgium) was used for all scans with the beam set at 90 kV and 270μA. Scans were reconstructed at 18μm isotropic resolution. All samples were scanned within 3 days after sacrifice. All reconstructions were performed using Skyscan NRecon Program (Bruker, Belgium). Measurements and analysis were conducted using SkyScan Dataviewer (Bruker, Belgium) and SkyScan CTan (Bruker, Belgium).
Mineralized tissues were classified into either mineralized bone or callus depending on the density of the intact cortical bone in the ulna. Based on previously published researches, the density of callus considered to be mineralized was 35%–70% of the maximum density of the intact cortical bone[18 (link)]. The density of intact mineralized bone was determined to be over 70% of the maximum intensity of the cortical bone. Cylindrical volume of interest (VOI) with a length of 10mm was used to analyzed the fracture zone, centered at the midpoint of the fracture in longitudinal view.
Volume and density were calculated for mineralized bone and mineralized callus. Morphometric parameters measured were as follows: mineralized callus volume, mineralized callus density, bone volume and bone mineral density.

Xu H., Xue Z., Ding H., Qin H, & An Z. (2015). Callus Formation and Mineralization after Fracture with Different Fixation Techniques: Minimally Invasive Plate Osteosynthesis versus Open Reduction Internal Fixation. PLoS ONE, 10(10), e0140037.

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