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Brd6688

Manufactured by Cayman Chemical
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BRD6688 is a highly-selective and potent bromodomain and extraterminal (BET) protein inhibitor. It functions by inhibiting the binding of BET proteins to acetylated histones, thereby modulating gene transcription.

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Lab products found in correlation

Rgfp966, by Merck Group (1 mentions) Mocetinostat, by Cayman Chemical (1 mentions) Ms 275, by Santa Cruz Biotechnology (1 mentions) Pronase, by Merck Group (1 mentions) Trichostatin a, by Cayman Chemical (1 mentions) Tmp195, by Cayman Chemical (1 mentions) Rgfp966, by Cayman Chemical (1 mentions) Cycloheximide (chx), by Merck Group (1 mentions)

2 protocols using brd6688

1

HDAC Inhibition Regulates Xist Induction

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For HDAC inhibition experiments, cells were treated with either HDAC1/2i (BRD6688, Cayman Chemical Company, 1404562-17-9) or HDAC3i (RGFP966, Sigma SML1652) at 10 uM final concentration. HDAC inhibition was initiated 24 hr prior to induction of Xist with doxycycline and continued for 24 hr during Xist induction (48 hr total). –HDACi samples were treated with DMSO as a control.
Carter A.C., Xu J., Nakamoto M.Y., Wei Y., Zarnegar B.J., Shi Q., Broughton J.P., Ransom R.C., Salhotra A., Nagaraja S.D., Li R., Dou D.R., Yost K.E., Cho S.W., Mistry A., Longaker M.T., Khavari P.A., Batey R.T., Wuttke D.S, & Chang H.Y. (2020). Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. eLife, 9, e54508.
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2

Modulation of HDAC and NLRP3 Pathways

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Pan-HDAC inhibitor Trichostatin A (TSA), class IIa HDAC inhibitors (HDAC4,5,7 and 9) TMP195, Class I & IV HDAC inhibitor (HDAC1,2,3 and 11) Mocetinostat, HDAC6 and 8 inhibitor BRD73954, HDAC3 inhibitor RGFP966 and a HDAC1 and 2 inhibitor BRD6688 were purchased from Cayman Chemical, HDAC1 and 3 inhibitor MS-275, and HDAC1 inhibitor 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide (DHOB) were purchased from Santa Cruz Biotechnology, NLRP3 specific inhibitor CP-456773/MCC 950, caspase-1 inhibitor caspase-1 Inhibitor II and protein synthesis inhibitor, cycloheximide, and pronase were purchased from Sigma-Aldrich. The stocks of all the chemical inhibitors were prepared in DMSO following the instructions of the vendors and stored at -80°C before use.
Moreira J.D., Iakhiaev A., Vankayalapati R., Jung B.G, & Samten B. (2022). Histone deacetylase-2 controls IL-1β production through the regulation of NLRP3 expression and activation in tuberculosis infection. iScience, 25(8), 104799.
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