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Fmoc l proline

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Fmoc-L-proline is a protected amino acid used as a building block in solid-phase peptide synthesis. It is a white crystalline powder that is soluble in organic solvents. Fmoc-L-proline is commonly used in the synthesis of peptides and proteins.

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Lab products found in correlation

Trifluoroacetic acid, by Chem-Impex (1 mentions) Diethyl ether et2o, by Merck Group (1 mentions) 18 crown 6, by Merck Group (1 mentions) Piperidine, by Chem-Impex (1 mentions) 7 ethyl 10 hydroxycamptothecin sn38, by Biosynth (1 mentions) Potassium carbonate, by Merck Group (1 mentions) Silica gel, by Merck Group (1 mentions) N n diisopropylethylamine, by Chem-Impex (1 mentions) Docosahexaenoic acid, by Cayman Chemical (1 mentions) Suberic acid, by Thermo Fisher Scientific (1 mentions) Arginylglycylaspartic acid, by Merck Group (1 mentions) L fucose, by Merck Group (1 mentions) Barnstead nanopure, by Thermo Fisher Scientific (1 mentions) 2 deoxy d galactose, by Merck Group (1 mentions) L rhamnose, by Merck Group (1 mentions) L rhamnulose, by Merck Group (1 mentions) Lc ms grade methanol, by Avantor (1 mentions) D fucose, by Merck Group (1 mentions) 2 deoxy d glucose, by Merck Group (1 mentions)

2 protocols using fmoc l proline

1

Synthesis of SN-38-PEG-DBCO Conjugate

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All reagents listed below were obtained from
commercial sources and used without further purification. H-His (Trt)-2-Cl-Trt
resin and H-Val-2-Cl-Trt resin were purchased from AAPPTEC (Louisville,
KY). Boc-L-alanine, Fmoc-L-alanine, Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydro-benzofuran-5-sulfonyl)-l-arginine, Nim-Trityl-L-histidine tert-butyl ester
hydrochloride, Fmoc-L-isoleucine, Fmoc-O-tert-butyl-L-tyrosine, Fmoc-L-proline,
Fmoc-6-aminohexanoic acid, 4-aminobenzyl alcohol (PABA), O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium
hexafluorophosphate (HATU),N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline(EEDQ),N,N′-diisopropylethylamine
(DIPEA), trifluoroacetic acid (TFA), and piperidine were purchased
from Chem Impex (Wood Dale, IL). 7-Ethyl-10-hydroxycamptothecin (SN-38)
was purchased from Biosynth (San Diego, CA). N,N-dimethylformamide
(DMF), dichloromethane (DCM), methanol (MeOH), tetrahydrofuran (THF),
acetonitrile (ACN), ethyl acetate (EtOAc), hexane, triisopropylsilane
(TIPS), phosphorus tribromide, diethyl ether (Et2O), silica
gel, 18-crown-6, and potassium carbonate were purchased from Sigma-Aldrich
(Burlington, MA). N3-PEG4-acid, Fmoc-N-amido-PEG3-acid, and DBCO-C6-acid were purchased from BroadPharm
(San Diego, CA).
Bataille Backer P., Adekiya T.A., Kim Y., Reid T.E., Thomas M, & Adesina S.K. (2024). Development of a Targeted SN-38-Conjugate for the Treatment of Glioblastoma. ACS Omega, 9(2), 2615-2628.
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2

Healthy Human Serum Compound Analysis

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Healthy human blood serum (S7023-50 mL) was purchased from Sigma-Aldrich (St. Louis, MO). FMOC-L-proline was procured from Chem-Impex International (Wood Dale, IL). Leucine enkephalin was obtained from ERA (Golden, CO). Arginyl-glycyl-aspartic acid, L-fucose, L-rhamnose, 1,5-anhydrosorbitol, D-fucose, L-rhamnulose, 2-deoxy-D-glucose, and 2deoxy-D-galactose were acquired from Sigma-Aldrich Bilirubin, and suberic acid was obtained from Alfa Aesar (Ward Hill, MA). Ricinoleic acid was purchased from MP Biomedicals (Santa Ana, CA). Docosahexaenoic acid and 3-oxo stearic acid were acquired from Cayman Chemical Company (Ann Arbor, MI). LysoPE(16:0) was obtained from Avanti Polar Lipids (Alabaster, AL). LC-MS grade methanol was purchased from J.T. Baker Avantor Performance Materials (Center Valley, PA). Ultrapure water with 18.2 MΩ cm resistivity (Barnstead Nanopure, Thermo Fisher Scientific, Waltham, MA) was used to prepare chromatographic mobile phases.
Jones C.M., Monge M.E., Kim J., Matzuk M.M, & Fernández F.M. (2015). Metabolomic serum profiling detects early-stage high-grade serous ovarian cancer in a mouse model. Journal of proteome research, 14(2).
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