Acl top 700 las

Venous blood samples from fasting patients were obtained within 24 hours after admission. Plasma fibrinogen was measured on ACL‐Top 700 LAS (Werfen, USA) with an automated clot rate assay as previously described.
¹⁶ (link) Serum albumin was tested with an automated chemistry analyzer (Beckman, Japan). All measurements were performed by laboratory personnel with standard biochemical techniques in the clinical laboratory of the Second Hospital of Hebei Medical University. The intra‐ and interassay coefficients of variation were 1.8% and 3.2%, and 1.5% and 1.6%, respectively. We performed all measurements blind to clinical outcomes.

The primary outcome of this study was the in‐hospital incidence of VTE, including upper and lower limb DVT, catheter‐related thrombosis, and pulmonary embolism (PE). Both computed tomography pulmonary angiogram and ventilation‐perfusion scan are used to detect PE in this center. Subsegmental PE was differentiated from nonsubsegmental PE. VTE was considered symptomatic when a clinical suspicion was confirmed with a technical investigation. Incidental VTE was any VTE found incidentally during a diagnostic examination not specifically aimed at detecting DVT or PE. The secondary endpoint was major bleeding as defined by the International Society on Thrombosis and Haemostasis.³⁶ Type and dose of anticoagulation at the time of bleeding were obtained, and major bleedings were subsequently reported as a percentage of all patients receiving the same type of anticoagulation and pooled by indication. Data on therapeutic, intermediate, and prophylactic dosages could therefore be reported. Further, markers of thromboinflammation were collected: D‐dimers reported as fibrinogen equivalent units (ACL TOP 700 LAS, Werfen; HemosIL D‐dimer HS 500, Werfen) and C‐reactive protein (CRP; Cobas 8000, Roche; Cobas CRP4, Roche).