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Jd5037

Manufactured by MedChemExpress
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Sourced in China

JD5037 is a lab equipment product manufactured by MedChemExpress. It is a high-performance product designed for use in various scientific applications.

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Lab products found in correlation

Rapamycin, by Cayman Chemical (1 mentions) Wortmannin, by Cayman Chemical (1 mentions) Win 55, by Cayman Chemical (1 mentions) Ym 254890, by Adipogen (1 mentions) Rimonabant, by Cayman Chemical (1 mentions) Am6545, by Bio-Techne (1 mentions) Oleamide, by Bio-Techne (1 mentions)

4 protocols using jd5037

1

Pharmacological Inhibitor Purchasing Protocol

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ACEA, Wortmannin, WIN 55,212-2, and Rapamycin were purchased from Cayman Chemical (USA). PTX was purchased from Sigma-Aldrich (Israel). YM-254890 was purchased from AdipoGen (USA). JD5037 and DO34 were purchased from MedChemExpress (China).
Hinden L., Ahmad M., Hamad S., Nemirovski A., Szanda G., Glasmacher S., Kogot-Levin A., Abramovitch R., Thorens B., Gertsch J., Leibowitz G, & Tam J. (2022). Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function. Nature Communications, 13, 1783.
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2

Zebrafish Embryo Assay with Cannabinoid Modulators

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Win 55,212–2 (WIN), Rimonabant (RIMO), 4-diethylaminobenzaldehyde (DEAB), Oleamide (OLE), AM65445 and JD5037 were dissolved into dimethyl sulfoxide (DMSO) in a stock solution of 10 mM. All-trans retinoic acid (RA) was dissolved into ethanol in a stock solution of 100 mM. Solutions were stored at −20°C. Embryos were placed into 25 ml of E3 medium in 50 ml tubes. Appropriate volumes of chemicals were added directly to the medium and tubes were placed horizontally in an incubator at 28.5°C. Oleamide and AM6545 were purchased from Tocris Bioscience (Bristol, UK). Rimonabant was purchased from Cayman Chemical (Ann Arbor, MI, USA). JD5037 was purchase from MedChem Express. DEAB and RA were purchased from Sigma-Aldrich. The concentration of the different drugs used in this project are based on our previous dose-response analysis of the compounds [29 (link)].
Fraher D., Mann R.J., Dubuisson M.J., Ellis M.K., Yu T., Walder K., Ward A.C., Winkler C, & Gibert Y. (2021). The endocannabinoid system and retinoic acid signaling combine to influence bone growth. Molecular and cellular endocrinology, 529, 111267.
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3

Inverse CB1 Agonist in NOD Mice

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Eight-week-old female NOD/ShiLtJ mice were given JD-5037 (2 mg/kg, MedChemExpress, Monmouth Junction, NJ), an inverse agonist to the CB1, by oral gavage for 4 weeks followed by an intraperitoneal glucose tolerance test.
Aseer K.R., Mazucanti C.H., O’Connell J.F., González-Mariscal I., Verma A., Yao Q., Dunn C., Liu Q.R., Egan J.M, & Doyle M.E. (2024). Beta cell specific cannabinoid 1 receptor deletion counteracts progression to hyperglycemia in non-obese diabetic mice. Molecular Metabolism, 82, 101906.
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4

Cytotoxic Agents Evaluation Protocol

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CYP (ENDOXAN) was purchased from Baxter Oncology (Germany). JD5037 was purchased from MedChemExpress (China).
Hinden L., Ludyansky R., Leidershnaider S., Harris Y., Nemirovski A., Gofrit O.N., Tam J, & Hidas G. (2023). Peripheral Cannabinoid-1 Receptor Blockade Ameliorates Cystitis Severity. Cannabis and Cannabinoid Research, 8(4), 623-633.
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