Gammaplan software

Manufactured by Elekta

Sourced in Sweden

GammaPlan is a software application developed by Elekta for treatment planning in radiation therapy. It provides tools for visualizing and analyzing 3D medical images, such as CT and MRI scans, and generating radiation treatment plans.

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Lab products found in correlation

Perfexion, by Elekta (2 mentions) Mri machine, by GE Healthcare (1 mentions) Leksell model g frame, by Elekta (1 mentions) Gamma knife icon unit, by Elekta (1 mentions) Leksell gamma knife unit, by Elekta (1 mentions) Prisma fit, by Siemens (1 mentions) Leksell gamma unit model c, by Elekta (1 mentions) Gamma knife, by Elekta (1 mentions)

Spelling variants of this product

GammaPlan (17 citations) Leksell GammaPlan software (10 citations)

15 protocols using gammaplan software

Retrospective Study of Paraganglioma Patients

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Following Mayo Clinic IRB approval, a retrospective review of paper and electronic medical records for all patients with a diagnosis of JP treated with GKRS was performed. Diagnosis was established based on patient history, physical examination, imaging findings, and histopathology results (where available).
Clinical and operative notes as well as pathology and imaging reports were reviewed to obtain the follow-ing demographic data: age at radiosurgery, sex, laterality, prior treatment, diagnosis of familial paraganglioma, and CN function. Prior surgery included biopsy, subtotal resection (STR), near-total resection (NTR), and GTR. Radiation delivery parameters included marginal dose, maximum dose, volume treated, and number of isocenters. Maximum radiosurgical dose to the internal carotid artery (ICA), maximum cochlear dose, and mean cochlear dose were measured using the dose measurement tool in the GammaPlan software (Elekta AB). Lower CN function was examined with flexible fiberoptic or mirror laryngoscopy. Facial nerve function was graded using the House-Brackmann grading system. 21

Patel N.S., Carlson M.L., Pollock B.E., Driscoll C.L.W., Neff B.A., Foote R.L., Lohse C.M, & Link M.J. (2019). Long-term tumor control following stereotactic radiosurgery for jugular paraganglioma using 3D volumetric segmentation. Journal of neurosurgery, 130(2).

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Brain Metastases Radiosurgery Protocol

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Radiosurgery was performed as previously described^{19 (link),20 (link)}. In brief, patients underwent Magnetic Resonance Imaging (MRI) of the brain with either the Toshiba America Medical Systems MRI machine (Tustin, California) at 2 mm slices or the GE Healthcare MRI machine (Milwaukee, Wisconsin) using 1 mm slices in conjunction with the Leksell stereotactic head frame. MRI was performed using axial and coronal T1-weighted pre- and post-contrast sequences. Following the initial MR radiography, cases underwent review by a team consisting of at least one of each of the following specialists: neurosurgeon, radiation oncologist, and medical physicist. Planning of the radiation dose for each of the metastases was performed using the Elekta Gamma Plan software. The calculated dose was given to the 50% isodose line in all patients. Generally speaking, dosing was in line with the RTOG 95-08 clinical trial⁴. Patients’ clinical presentation/status, number of metastases, tumor volume, and prior or planned WBRT were all weighed prior to the final determination of dosage. Doses to particularly sensitive areas of the brain such as the optic nerve and brainstem were limited to 10 Gy and 18 Gy respectively with no single dose of radiation exceeding 24 Gy.

Ali M.A., Hirshman B.R., Wilson B., Carroll K.T., Proudfoot J.A., Goetsch S.J., Alksne J.F., Ott K., Aiyama H., Nagano O., Carter B.S., Fogarty G., Hong A., Serizawa T., Yamamoto M, & Chen C.C. (2017). Survival patterns of 5750 SRS-treated brain metastasis patients as a function of the number of lesions. World neurosurgery, 107, 944-951.e1.

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Longitudinal MRI-T1-C Volumes in Brain Metastases

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The BM volumes on MRI T1-contrast enhanced imaging (MRI-T1-C) were measured utilizing the GammaPlan software (Elekta, Stockholm, Sweden) at GKS and during follow-up at 1 and 3 months, then every third month post-GKS until September 30, 2019 or death. Follow-up images were available for 348 (85.7%) out of 406 BM in 87 (89.7%) of the 97 patients (95.6% of the 91 patients alive at first MRI 1 month post-SRS). Two patients (2.1%) are still alive in September 2019.

Skeie B.S., Enger P.Ø., Knisely J., Pedersen P.H., Heggdal J.I., Eide G.E, & Skeie G.O. (2020). A simple score to estimate the likelihood of pseudoprogression vs. recurrence following stereotactic radiosurgery for brain metastases: The Bergen Criteria. Neuro-oncology Advances, 2(1), vdaa026.

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Stereotactic Radiosurgery Protocol

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Patients underwent placement of a stereotactic Leksell G-frame in the operating room. During frame placement, they received monitored anesthesia administered by an anesthesiologist. Stereotactic MR imaging was then obtained for treatment planning. Pre- and post-contrast thin-slice (1-mm) axial and coronal MR sequences were obtained. When MR imaging could not be obtained because of medical contraindications (such as the presence of a cardiac pacemaker), a thin-slice stereotactic CT scan was obtained with and without contrast administration. Radiosurgical dose plans were formulated under the direction of a neurosurgeon in conjunction with a medical physicist and radiation oncologist. The Leksell Gamma Unit Model C model (Elekta Instruments, Inc.) was used until 2007 when the Perfexion and later the Icon were used. Elekta’s GammaPlan software was used.

González E.O., Runge S., Mantziaris G., Ironside N, & Sheehan J.P. (2024). Stereotactic radiosurgery for brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia. Acta Neurochirurgica, 166(1), 21.

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Standardized SRS Dosimetric Protocol

Cited 1 time

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In all four centers, initial imaging was performed using 1mm axial and coronal T1-weighted pre- and post-contrast MR sequences. Treatment plan was formulated by a team consisting of neurosurgeons, radiation oncologists, and medical physicists. Elekta's Gamma Plan software was used for dosimetric planning. SRS dosimetric parameters were generally consistent with the published literature.[9 (link), 11 (link)] The 50% isodose line was prescribed for each patient. Dose to the optic nerve was limited to 10 Gy; while dose to the brainstem was limited to 18 Gy. The mean dose received by the whole brain during any single SRS session was limited to <3 Gy.

Ali M.A., Hirshman B.R., Wilson B., Schupper A.J., Joshi R., Proudfoot J.A., Goetsch S.J., Alksne J.F., Ott K., Aiyama H., Nagano O., Carter B.S., Chiang V., Serizawa T., Yamamoto M, & Chen C.C. (2017). Improving the prognostic value of disease specific Graded Prognostic Assessment (ds-GPA) model for renal cell carcinoma by incorporation of Cumulative Intracranial Tumor Volume (CITV). World neurosurgery, 108, 151-156.

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Stereotactic Radiosurgery for Intracranial Metastases

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GKRS procedures were performed as described previously. 30 Patients were selected for the GKRS procedure according to existing guidelines considering intracranial tumor burden, number and size of intracranial metastases, functional status, and systemic tumor control. GKRS plans were tailored to the individual patient situation considering size, number, and location of intracranial metastases and prior radiation therapy. All patients underwent GKRS using the Gamma Knife Icon unit (Elekta AB). We used frame-based stereotaxy with the Leksell model G-frame (Elekta AB). The frame was placed under local anesthesia with conscious sedation. Afterward, thin-slice CT scans were acquired and merged with the thin-slice contrast-enhanced T1-weighted brain MR images that were used for treatment planning. Planning MRI was performed within 1 week preceding the SRS procedure. Treatment plans were generated using the GammaPlan software (Elekta AB). GKRS dose planning was performed by a multidisciplinary team that included a neurosurgeon, radiation oncologist, and medical physicist.

Bunevicius A., Lavezzo K., Shabo L., McClure J, & Sheehan J.P. (2021). Quality-of-life trajectories after stereotactic radiosurgery for brain metastases. Journal of neurosurgery, 134(6).

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Gamma Knife Thalamic Radiosurgery for Pain

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Radiosurgery was performed using the Leksell Gamma Knife models B, C, and Perfexion (Elekta Instruments). MRI was performed at 1.5 T and included T1-weighted 3D fast low-angle shot (1.3-mm slice thickness) as well as T2-and proton density-weighted sequences (2-mm slice thickness). Radiation planning was performed using Gam-maPlan software (Elekta Instruments). The intralaminar nuclei (centromedian [CM] and parafascicularis [Pf] nucleus) of the medial thalamus 9, 14 were chosen as the target (Fig. 1) for irradiation with the following coordinates: X = 4-6 mm lateral to wall of the third ventricle; Y = 7-8 mm posterior to the midpoint; and Z = 2-3 mm above the anterior commissure-posterior commissure line contralateral to pain symptoms. The radiation itself was performed using a 4-mm collimator and a single shot with an applied maximal dose between 145 and 150 Gy (Fig. 1). MRI with contrast administration was performed 3-9 months after GKT in 8 patients.

Urgosik D, & Liscak R. (2018). Medial Gamma Knife thalamotomy for intractable pain. Journal of neurosurgery, 129(Suppl1).

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Stereotactic Radiosurgery for Pituitary Adenomas

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The SRS technique for treatment of patients with pituitary adenomas at our institution has been previously described. 11 In brief, a high-resolution MRI was obtained before and after contrast administration, combined with fat suppression, at 1mm slice thickness. A Leksell stereotactic Gamma Knife frame was placed under monitored anesthesia care. Following frame placement, a CT was obtained and merged with the high-resolution MRI. Dose planning was performed using the GammaPlan software (Elekta AB, Sweden) by a multidisciplinary team comprising a neurosurgeon, radiation oncologist, and medical physicist. SRS was performed using the Leksell Gamma Knife Unit (Elekta AB, Sweden); the model varied depending upon the time of treatment.

Ironside N., Snyder H., Xu Z., Schlesinger D., Chen C.J., Vance M.L., Hong G.K., Jane JA J.r, & Sheehan J.P. (2022). Effect of distance from target on hypopituitarism after stereotactic radiosurgery for pituitary adenomas. Journal of neuro-oncology, 158(1).

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Brain Tumor MRI Protocol for Volumetric Analysis

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The patients were scanned on a 1.5T or a 3T clinical MR scanner (Siemens Prisma Fit, Erlangen, Germany). The brain tumor MRI protocol included post-contrast (Gadolinium-DTPA) T1-weighted (T1w-Gd) TurboFLASH volumetric imaging (repetition time [TR] = 2080 ms, echo time [TE] = 2.67 ms at 3T; TR = 2240 ms, TE = 3.04 ms at 1.5T) and 3D fluid-constructive interference of steady-state (TR = 5.72 ms, TE = 2.55 ms at 3T; TR = 5.76 ms, TE = 2.58 ms at 1.5T). Each target volume was manually delineated by a neurosurgeon (K.Ö.) with 17 years of experience using Gamma Plan Software (Elekta-Sweden) on T1w-Gd. Three-dimensional models of each tumor were created from the region of interests (ROIs) using 3D Slicer software^{22 (link),23}.

Sümer E., Tek E., Türe O.A., Şengöz M., Dinçer A., Özcan A., Pamir M.N., Özduman K, & Ozturk-Isik E. (2022). The effect of tumor shape irregularity on Gamma Knife treatment plan quality and treatment outcome: an analysis of 234 vestibular schwannomas. Scientific Reports, 12, 21809.

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Unilateral Gamma Knife Thalamotomy for Tremor

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Unilateral GKT procedures were performed at the Warsaw Gamma Knife Centre. After stereotactic frame placement, contrast-enhanced 1 mm slice thickness axial T1, 3D, T2 FSE, Monika Figura et al., Unilateral gamma knife thalamotomy for tremor safety and efficacy in multimodal assessment and FIESTA MR images were used for planning. A conformal plan was constructed in GammaPlan Software (Elekta, Sweden) using a 4 mm isocentre. The prescribed standard dose of 130 Gy was applied to all patients. All patients were operated on with a 192-source cobalt-60 Gamma Knife Perfexion unit. All imaging was performed in a GE Sigma HDxt 1.5T magnetic resonance imaging scanner and a 64-row GE computer tomography scanner.

Figura M., Przytycka J., Dzierzęcki S., Szumilas M., Szlufik S., Milanowski Ł., Kłoda M., Duszyńska-Wąs K., Kowalska-Taczanowska R., Drzewińska A., Sadowski K., Korn A., Ziobro A., Bochniak K., Friedman A., Ząbek M, & Koziorowski D. (2024). Unilateral gamma knife thalamotomy for tremor safety and efficacy in multimodal assessment: a prospective case-control study with two-year follow-up. Neurologia i neurochirurgia polska, 58(3).

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