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118 protocols using r software 3

1

Factors Influencing Homicide Outcomes

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The data were analyzed using R Software 3.6.3. Quantitative variables are presented as means and standard deviations, and qualitative variables as frequencies and percentages. We also performed a bivariate analysis to identify possible factors associated with Injury mechanism and status and admission as well as to assess differences between data from years 2007 and 2017. For this purpose the Kruskal–Wallis test, Chi-square test, and Spearman correlation coefficient were calculated accordingly.
In order to explore more deeply the factors associated with place at death, we use Classification and Regression Trees48 as implemented in Rpart R package49 as an exploratory tool to uncover complex interactions between selected covariates and the place at death. This method has been used before successfully by one of the authors to explore associations on outcomes of interest in the context of observational studies (see for example50 –52 (link)).
Finally, georeferencing maps were done using R Software 3.6.3 and Google Maps. Coordinates of homicide and trauma hospitals were obtained by Google Maps and introduced in R Software 3.6.3. With the data, a heat map on homicide cases, rates per locality, and the rate of arrival to the emergency room with vital signs per locality were graphed.
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2

Meta-Analysis of Survival Data

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Data analyses were performed using RevMan software 5.3 (Cochrane Collaboration, Oxford, UK) and the “meta” package in R software 3.6.0 (R Foundation for Statistical Computing, Vienna, Austria) [13 ]. Odds ratios (ORs) were used to compare dichotomous variables. The natural logarithm of HRs and the corresponding standard error were used for the meta-analysis of survival data [14 (link)]. We tested heterogeneity by Cochran’s Q test and Higgins I2 statistic. A P value by Q test of less than 0.10 and I2 > 50% indicated existence of statistically significant heterogeneity. A random-effects model was used for outcomes when heterogeneity existed; otherwise, a fixed-effects model was used. Sensitivity analysis was conducted by sequentially omitting each individual study in order to evaluate the stability of the synthetic results. We also assessed publication bias using contour-enhanced funnel plot [15 ] with a P value lower than 0.05 for Egger’s test indicating significant statistical publication bias [16 ]. All results were reported with 95% confidence intervals (CIs), and a two-sided P value of < 0.05 was considered statistically significant.
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3

Reliability Assessment of Screw Positioning

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Statistical analysis was performed using R Software 3.6.0 (R Foundation for Statistical Computing, Vienna, Austria). The reliability of rating screw positioning according to Gertzbein and Robins was compared between the observers, and for each observer, between both assessments. Likewise, the image quality scale was tested using Intraclass Correlation Coefficients (ICC) for categorical data. Observer agreement was then compared between NoMAR and MAR. The values of intraclass correlation coefficients were rated according to Landis and Koch [18 (link)]: correlation was considered excellent if r > 0.80, good if r = 0.61 to 0.80, fair if r = 0.41 to 0.60, and poor if r ≤ 0.40.
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4

Coagulation Factors and Cardiovascular Diseases

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The fixed‐effects inverse‐variance weighted method was used to assess the associations of coagulation factors with 10 CVDs (5 primary and 5 secondary outcomes) in the main analysis.18 Estimates were combined from different data sources using the fixed‐effects meta‐analysis method. The invariance weighted method with random effects was used to estimate the association of genetically predicted aPTT and PT with CVDs. All odds ratios and 95% CIs of the CVD outcomes were scaled to a 1‐second increase in aPTT and PT. The Bonferroni correction method was used to account for multiple testing. We deemed associations with P<0.001 (where P=0.05/54 [6 primary outcomes and 9 coagulation factors]) as strong evidence of causal associations. Associations with P<0.05 but >0.001 were treated as suggestive evidence of associations. Analyses were performed using the mrrobust package19 in Stata/SE 15.0 (StataCorp, College Station, TX) and the MendelianRandomization20 and TwoSampleMR17 packages in R software 3.6.0 (R Foundation for Statistical Computing, Vienna, Austria).
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5

Identifying Risk Factors for Postpartum SUI

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Statistical analysis was performed using SPSS software version 23.0 (IBM, Armonk, NY, USA), R software 3.6.0 (The R Foundation for Statistical Computing). The association between candidate predictive variables and SUI was evaluated using a univariate analysis. In quantitative data, use median and IQRs to represent. The χ2 test was used to compare the classified data. A multivariate logistic regression analysis was used to determine the risk factors for SUI. The odds ratio (ORs) and their associated 95% confidence intervals (CIs) were calculated. A receiver operating characteristic (ROC) curve analysis was used to determine the optimal threshold from the area under the curve. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of each index in the diagnosis of postpartum SUI were calculated.
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6

Lung Transplant vs. Lung Volume Reduction

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Variables were reported as the pooled mean with 95% confidence intervals (CI). For dichotomous variables, a meta‐analysis of proportions with logit transformation was conducted. Continuous data were combined via meta-analysis with random‐effects model. Heterogeneity was evaluated using I2 test. Survival data from each study were collected and pooled to retrieve a weighted mean and 95% CI at specific time points. Such data were then graphically displayed to visualize survival over time. The main analysis was undertaken to compare patients undergoing LTx vs. lung volume reduction surgery (LVRS). Subgroup analysis was further undertaken for surgical vs. endobronchial techniques of LVR. Propensity matching was not done due to the limitations of the meta-analysis method. R software 3.5.0, meta package (R Foundation for Statistical Computing, Vienna, Austria) was used for data analysis. P values <0.05 were considered statistically significant.
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7

Survival Analysis of Patient Cohorts

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We performed descriptive statistics to describe baseline patient characteristics (age, sex, and risk stratification). Kaplan-Meier survival curves were generated for OS and EFS, and hazard ratios and 95% CIs were calculated. Log-rank tests were used to determine the statistical significance of differences in OS and EFS between the preimplementation and the postimplementation cohorts. Statistical analyses were conducted using R software (3.5.0; R Foundation for Statistical Computing, Vienna, Austria). We considered a P ≤ .05 to indicate statistical significance.
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8

Comparative Analysis of Continuous Variables

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Continuous variables were expressed as median (interquartile range). The Mann-Whitney U-test was used to compare continuous variables. Fisher’s exact probability test was used to analyze the differences between discrete variables. Statistical significance was set at p < 0.05. All statistical analyses were performed using R software 3.5.0 (The R Foundation for Statistical Computing, Vienna, Austria).4
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9

Dyslipidemia in HIV-infected Children

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Descriptive statistics were presented using mean (standard deviation-SD), median (inter quartile rage-IQR), and frequency (percentage). Total cholesterol, triglyceride, LDLc and HDLc values were dichotomized to abnormal or within normal limits (WNL). The association between abnormal lipid profile values and independent variables was assessed using non-parametric tests as the data were found to be non-normally distributed by the Schapiro Wilk test. Groups were compared using Fisher´s exact test for categorical variables and Wilcoxon Rank sum test for continuous variables. To assess for factors which are independently associated with dyslipidemia among cART naïve and experienced HIV-infected children, a multivariate binary logistic regression was done using covariates with a p-value < 0.20 in the bivariate analysis. For the multivariate model, a p-value < 0.05 was considered as statistically significant. R software 3.5.0(The R Foundation for Statistical Computing, Vienna, Austria) and Graph Pad Prism 7.04 (GraphPad Software, La Jolla, CA, USA) were used for statistical analysis and for graphics.
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10

Statistical Analysis of Research Data

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Data were statistically examined by means of R software 3.5.0 (The R Foundation for Statistical Computing©) and Rcmdr 2.5-1 package (Fox, 2005) . The comparison between different
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