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Fructosamine

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Fructosamine is a laboratory test that measures the average level of glucose in the blood over a 2-3 week period. It is used to monitor long-term glycemic control in individuals with diabetes.

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Lab products found in correlation

Modular p800 system, by Roche (6 mentions) A1c 2.2 plus glycohemoglobin, by Tosoh (1 mentions) G7 analyzer, by Tosoh (1 mentions) Ferritin, by Randox (1 mentions) Au400 analyzer, by Beckman Coulter (1 mentions) Hplc d10, by Bio-Rad (1 mentions) Cobas 6000, by Roche (1 mentions)

8 protocols using fructosamine

1

Glycemic Biomarkers in Long-Term Samples

Cited 3 times
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Serum glucose was measured in fresh samples at visit 2 using the hexokinase method. HbA1c was measured in whole blood samples collected at visit 2 stored at −80 Celsius degrees using high-performance liquid chromatography with instruments standardized to the Diabetes Control and Complications Trial assay (Tosoh A1c 2.2. Plus Glycohemoglobin in 2003–2004 and Tosoh G7 analyzers 2007–2008) [17 (link)]. Fructosamine (Roche Diagnostics Corp, Indianapolis, IN, USA), glycated albumin (Asashi Kasei Lucica GA-L, Tokyo, Japan), and 1,5-AG (GlycoMark, Winston-Salem, NC) were measured in 2012–2013 in stored frozen serum using a Roche Modular P800 system [14 (link),18 (link)]. Previous studies have shown these analytes to be reliable in long-term stored samples [19 –21 (link)].
Ding N., Kwak L., Ballew S.H., Jaar B., Hoogeveen R.C., Ballantyne C.M., Sharrett A.R., Folsom A.R., Heiss G., Salameh M., Coresh J., Hirsch A.T., Selvin E, & Matsushita K. (2018). Traditional and nontraditional glycemic markers and risk of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis, 274, 86-93.
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2

Plasma Clinical Chemistry Analysis

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Blood was collected under terminal anaesthesia into heparinized tubes for plasma preparation. Within 1 hour of collection, blood samples were centrifuged and plasma recovered and stored at -20°C until analysis. Clinical chemistry analysis of plasma was performed using the Olympus AU400 analyzer (Beckman Coulter Ltd) and was blinded to the operator via barcodes.
The majority of parameters were measured using kits and controls supplied by Beckman Coulter. Samples were also tested for haemolysis. Four parameters were measured by kits not supplied by Beckman Coulter: transferrin, ferritin (Randox Laboratories Ltd), fructosamine (Roche Diagnostic) and thyroxine (Thermo Fisher).
Duque-Correa M.A., Karp N.A., McCarthy C., Forman S., Goulding D., Sankaranarayanan G., Jenkins T.P., Reid A.J., Cambridge E.L., Ballesteros Reviriego C., Müller W., Cantacessi C., Dougan G., Grencis R.K, & Berriman M. (2019). Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection. PLoS Pathogens, 15(1), e1007265.
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3

Glycated Albumin and Fructosamine Measurement

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Both Fructosamine and glycated albumin were measured from serum samples collected at visit 2 (1990–1992). Samples were stored at −70°C. Fructosamine (Roche Diagnostics, Indianapolis IN, USA) and glycated albumin (GA-L Asashi Kasei Pharma Corporation, Tokyo, Japan) were measured in 2012–2013 using a Roche Modular P800 system. In this study, glycated albumin was expressed as percent glycated albumin: [(glycatedalbuminconcentration(g/dL)/serumalbuminconcentration(g/dL))×100/1.14]+2.9 .
Ray D., Loomis S.J., Venkataraghavan S., Tin A., Yu B., Chatterjee N., Selvin E, & Duggal P. (2023). Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study. medRxiv.
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4

Biomarkers Measurement Protocol

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Glucose and insulin were measured in plasma on the Cobas 6000 instrument (Roche Diagnostics, USA) using an enzymatic hexokinase assay or electrochemiluminescence, respectively. HbA1c was determined using the HPLC D10 instrument (Bio-Rad, USA). High sensitivity C-reactive protein (hsCRP) was measured in plasma with the immunoturbidometric method assay (Abbott Architect, USA). Fructosamine was measured in serum via colorimetric rate reaction (Roche Diagnostics, USA). Cholesterol, triglyceride and HDL cholesterol concentrations were measured by enzymatic assays (Abbott Architect, USA). LDL was calculated with the following equation:
LDL = (1.06*Chol) – (1.03*HDLC) – (0.117*Trig) – (0.00047*(TRIG*(Chol-HDLC))) + (0.000062*(Trig*Trig)) – 9.44
Dixon S.A., Mishra S., Dietsche K.B., Jain S., Mabundo L., Stagliano M., Krenek A., Courville A., Yang S., Turner S.A., Meyers A.G., Estrada D.E., Yadav H, & Chung S.T. (2023). The effects of prebiotics on gastrointestinal side effects of metformin in youth: A pilot randomized control trial in youth-onset type 2 diabetes. Frontiers in Endocrinology, 14, 1125187.
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5

Measurement of Fructosamine and Glycated Albumin

Cited 2 times
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Fructosamine (Roche Diagnostics Corp, Indianapolis, IN, USA) and glycated albumin (Lucia GA-L, Asahi Kasei Corp, Tokyo, Japan) were measured in 2012–2013 from serum samples, using a Roche Modular P800 system. Samples had been stored at −70°C since collection during the baseline examination in 1990 to 1992. For Fructosamine, the inter-assay coefficients of variation (CVs) were 3.2% at a concentration of 212.6 umol/L and 2.5% at a concentration of 856.7 umol/L%. For glycated albumin, the inter-assay CVs were 2.3% at a concentration of 1.579 g/dL and 2.8% at a concentration of 0.426 g/dL. Previous studies have demonstrated the stability of these analytes in long-term stored samples7 (link)–9 (link).
Selvin E., Rawlings A.M., Lutsey P., Maruthur N., Pankow J.S., Steffes M, & Coresh J. (2015). Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death. Circulation, 132(4), 269-277.
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6

Glycemic Biomarkers Measured in ARIC Cohort

Cited 1 time
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Samples for all glycemic biomarkers were collected at ARIC visit 2 (1990–1992). Fructosamine (Roche Diagnostics, Indianapolis IN, USA), glycated albumin (GA-L Asashi Kasei Pharma Corporation, Tokyo, Japan) and 1,5-AG (GlycoMark, Winston-Salem, NC) were measured in 2012–2013 using a Roche Modular P800 system from samples stored at −70°C. Glucose was measured at visit 2 using the Roche Hitachi 911 analyzer using the hexokinase method (Roche Diagnostics). HbA1c was measured at visit 2 in stored whole blood samples using high performance liquid chromatography, using NGSP-certified assays standardized to the Diabetes Control and Complications Trial (Selvin 2010 (link)).
Loomis S.J., Tin A., Coresh J., Boerwinkle E., Pankow J.S., Köttgen A., Selvin E, & Duggal P. (2019). Heritability analysis of nontraditional glycemic biomarkers in the Atherosclerosis Risk in Communities (ARIC) Study. Genetic epidemiology, 43(7), 776-785.
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7

Fructosamine and Glycated Albumin Measurement

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Fructosamine (Roche Diagnostics) and glycated albumin (Asashi Kasei Lucica GA-L, Tokyo, Japan) were measured in 2012–2013 from stored serum specimens using a Roche Modular P800 system. The inter-assay coefficients of variation were 3.0% for Fructosamine and 1.8% for glycated albumin.
Selvin E., Rawlings A.M., Grams M., Klein R., Sharrett A.R., Steffes M, & Coresh J. (2014). Prognostic utility of fructosamine and glycated albumin for incident diabetes and microvascular complications. The lancet. Diabetes & endocrinology, 2(4), 279-288.
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8

Glycated Albumin and Fructosamine Measurements

Cited 2 times
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Fructosamine (Roche Diagnostics, Indianapolis, IN) and glycated albumin and serum albumin (GA-L; Asahi Kasei Pharma Corporation, Tokyo, Japan) were measured in 2012–2013 using a Roche Modular P800 system from serum collected at visit 2 and stored at −70°C (3 (link)). Percent glycated albumin was calculated per the manufacturer’s protocol: [(glycated albumin concentration in g/dL/serum albumin concentration in g/dL)*100/1.14] + 2.9. We also examined total glycated albumin (g/dL) as well as serum albumin (g/dL) to help distinguish genetic factors specific to serum protein concentration versus hyperglycemia.
Serum glucose was measured on the Roche Hitachi 911 analyzer using the hexokinase method (Roche Diagnostics), and HbA1c was measured from whole blood stored at −70°C using high-performance liquid chromatography, standardized to the assay used in the Diabetes Control and Complications Trial (DCCT) (27 (link)).
Loomis S.J., Li M., Maruthur N.M., Baldridge A.S., North K.E., Mei H., Morrison A., Carson A.P., Pankow J.S., Boerwinkle E., Scharpf R., Rasmussen-Torvik L.J., Coresh J., Duggal P., Köttgen A, & Selvin E. (2018). Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study. Diabetes, 67(8), 1684-1696.
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