Fibroscan, also known as transient elastography (TE), was performed by three trained operators, following the manufacturer's protocol. The operators used Fibroscan (FibroScan® 502 Touch system; Echosens, Paris, France) equipped with a standard probe. The procedure was performed as previously described (15 (link)). A result was considered reliable if: i) ≥10 successful shots of TE; ii) the success rate was ≥60% and iii) the inter-quartile median ratio was <30%. The results of TE are expressed in kPa.
Fibroscan 502 touch system
Manufactured by Echosens
Sourced in France
The FibroScan® 502 Touch system is a medical device designed for the non-invasive assessment of liver stiffness and fat content. It utilizes vibration-controlled transient elastography (VCTE) technology to measure liver stiffness and controlled attenuation parameter (CAP) technology to quantify liver fat. The system provides objective and reproducible results to support clinical decision-making.
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4 protocols using fibroscan 502 touch system
1
Transient Elastography Protocol for Liver Assessment
2
Longitudinal VCTE and CAP Monitoring
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Enrolled subjects returned for follow‐up visits every week for the first four weeks, and then every two weeks until 24 weeks or end of their participation. VCTE for LSM (in kilopascals [kPa]) and controlled attenuation parameter (CAP) as semiquantitative determination of hepatic steatosis (in decibels per meter [dB/m]) were performed at baseline and every follow‐up visit by a single trained operator using a FibroScan® 502 Touch system (Echosens), with the choice of probe guided by the system software. VCTE measurements were considered valid if at least 10 valid measurements and interquartile range over median of <30% were obtained.18
3
Transient Elastography for Liver Fibrosis
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LSM was performed using the FibroScan® 502 Touch system equipped with the standard probe (Echosens, Paris, France) according to the instructions by experienced physicians. Reliable transient elastography measurements were defined as median values of 10 valid LSM, with interquartile range <30% and success rate ≥60% (13 (link)). Liver fibrosis stages F0–F4 according to LSM were set as follows: no/little fibrosis (F0/F1), <7.3 kPa; significant fibrosis (F2), ≥7.3 and <9.7 kPa; advanced fibrosis (F3), ≥9.7 and <12.4 kPa; cirrhosis (F4), ≥12.4 kPa.
4
Liver Stiffness Measurement by Transient Elastography
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Liver stiffness measurements were made by transient elastography based on ultrasound using a FibroScan-502® Touch system (Echosens, Paris, France) with M-probe and XL-probe. Patients were placed in the supine position with the right hand at maximal abduction for right lobe liver scanning. Measurements were considered valid when there were at least 10 measurements with LSM values of ≥ 60% and an interquartile range of < 30%, and the median value of these measurements was used for analysis.
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