Lenalidomide

Manufactured by Bio-Techne

Sourced in United Kingdom

Lenalidomide is a chemical compound used in various laboratory research applications. It is a small molecule that functions as a modulator of certain cellular processes. The core function of Lenalidomide is to interact with and modify the activity of specific proteins or biological pathways, which may be relevant for various research areas. Further details on the intended use or applications of Lenalidomide are not provided to maintain an unbiased and factual approach.

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2 protocols using lenalidomide

Chemical Library Screening for Novel Therapeutics

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The SelleckChem library from the Molecular Screening Facility at the Wistar Institute was used for initial screens. However, once hits were identified, additional material was purchased for further testing. Mubritinib (S2216), Carmofur (S1289), Erlotinib HCl (S1023), NSC-207895 (S2678), OSI-420 (S2205), Emodin (S2295), TAK-285 (S2784), and Deguelin (S8132) were purchased from SelleckChem. Linifanib (M15676), Regorafenib (R16040), and Afatinib (G-7208) were purchased from AChemBlock. Adrucil (228440010) and Cytarabine (449561000) were purchased from Acros Organics. Lenalidomide (6305/100) and Dopamine HCl (3548/50) were purchased from Tocris Bioscience. Dacomitinib (PZ0330) and Rotenone (R8875) were purchased from Sigma. Rapamycin (J62473) was purchased from Alfa Aesar.

Calderon A., Soldan S.S., De Leo A., Deng Z., Frase D.M., Anderson E.M., Zhang Y., Vladimirova O., Lu F., Leung J.C., Murphy M.E, & Lieberman P.M. (2020). Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism. Oncotarget, 11(46), 4224-4242.

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Cellular Assay with Chemical Modulators

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TL12-186, nocodazole, 2,3-DCPE, and lenalidomide were purchased from Tocris (Bristol, UK), and TAE-684 and MG132 were purchased from Selleckchem (Houston, TX). HEK293 cells were obtained from the American Type Culture Collection and cultured at 37 °C, 5% CO 2 , in DMEM (Gibco, Waltham, MA) containing 10% fetal bovine serum (Seradigm, Radnor, PA). Rabbit anti-CDK2 antibody was purchased from Cell Signaling Technologies (Danvers, MA), and rabbit anti-tubulin antibody was purchased from Abcam (Cambridge, UK).

Riching K.M., Schwinn M.K., Vasta J.D., Robers M.B., Machleidt T., Urh M, & Daniels D.L. (2021). CDK Family PROTAC Profiling Reveals Distinct Kinetic Responses and Cell Cycle-Dependent Degradation of CDK2. SLAS discovery : advancing life sciences R & D, 26(4).

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