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Modular p800 system

Manufactured by Roche
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Sourced in Japan, China, Switzerland

The Modular P800 system is a versatile laboratory equipment designed for automated sample processing. It is a modular platform that can be configured to perform various analytical and diagnostic tasks. The core function of the Modular P800 system is to provide an automated solution for sample handling, preparation, and analysis, streamlining laboratory workflows.

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Lab products found in correlation

Fructosamine, by Roche (6 mentions) Tina quant 2, by Roche (1 mentions) A1c 2.2 plus glycohemoglobin, by Tosoh (1 mentions) G7 analyzer, by Tosoh (1 mentions) Cobas analyzer, by Roche (1 mentions) Electrochemiluminescence immunoassay, by Roche (1 mentions) Rapidlab 860, by Bayer (1 mentions) Au400, by Beckman Coulter (1 mentions) P modular system, by Roche (1 mentions) Cobas c analyzer, by Roche (1 mentions) Modular analytics e170, by Roche (1 mentions) Massarray iplex, by Labcorp (1 mentions)

21 protocols using modular p800 system

1

Fasting Biomarker Measurement Protocol

Cited 1 time
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Fasting venous blood was collected from each fasting patient participating in the biomarker substudy within 24±12 hours after randomization. Blood samples were collected by face-to-face interviews at each center and delivered through cold-chain to Beijing Tiantan Hospital and stored at −80° C. GA assay was centrally measured with a specific equipment (catalog number 4085-717; Ruiyuan Bio-Technique Co.Ltd., Ningbo, China) through a Roche Modular P800 system. We used the percentage of total serum albumin to express the levels of GA. [38 (link), 39 (link)] Hs-CRP was measured through a turbidimetric immunoassay (Ji’en Technique Co Ltd, Shanghai, China) on a Roche Modular P800 system (Roche, Basel, Switzerland). [31 (link)] All measurements were centrally conducted by laboratory technicians who were not informed of study assignments and clinical outcomes of patients.
Guo Y., Wang G., Jing J., Wang A., Zhang X., Meng X., Zhao X., Liu L., Li H., Wang D., Wang Y, & Wang Y. (2021). Stress hyperglycemia may have higher risk of stroke recurrence than previously diagnosed diabetes mellitus. Aging (Albany NY), 13(6), 9108-9118.
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2

Glycemic Biomarkers in Serum Analysis

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Fasting glucose (mg/dL) and HbA1c (%) were measured in 2005–2006 using a Roche Hitachi 911 analyzer. Glucose was measured in serum using the hexokinase method (Roche Diagnostics). HbA1c was measured in whole blood via a Tina-quant II immunoassay method (Roche Diagnostics, Basel, Switzerland) and calibrated to the Diabetes Control and Complications Trial assay. Glycated albumin and total albumin (% and g/dL, respectively; Lucica GA-L; Asahi Kasei Pharma Corporation, Tokyo, Japan), fructosamine (µmol/L; Roche Diagnostics), and 1,5-AG (µg/mL; GlycoMark, Winston-Salem, North Carolina) were measured in 2009 in serum samples with a Roche Modular P800 system (Roche Diagnostics).16 (link) Glycated albumin was expressed as a percentage of total serum albumin according to the manufacturer's instructions, that is, [(glycated albumin)/(serum albumin)×100/1.14+2.9]%. The interassay coefficients of variation for glycated albumin, fructosamine, and 1,5-AG were 2.7, 3.7, and 4.8%, respectively.
Poon A.K., Juraschek S.P., Ballantyne C.M., Steffes M.W, & Selvin E. (2014). Comparative associations of diabetes risk factors with five measures of hyperglycemia. BMJ Open Diabetes Research & Care, 2(1), e000002.
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3

Glycemic Markers in Diabetes Diagnosis

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Individuals were defined as having diagnosed diabetes if they self-reported a physician diagnosis of diabetes or were taking glucose-lowering medication at or before the CARMRI visit. We further categorized individuals with and without diabetes according to clinically relevant categories of hemoglobin A1c (Hb A1c): <5.7, 5.7–6.4, ≥6.5% in persons without diagnosed diabetes and <7% or ≥7% in persons with diagnosed diabetes. Hb A1c was measured in whole blood using the Tinaquant II immunoassay method (Roche Diagnostics) on the Roche Hitachi 911 analyzer, a Diabetes Control and Complications Trial (DCCT)-aligned assay. Glucose was also measured on the Roche Hitachi 911 analyzer using the hexokinase method (Roche Diagnostics). Fructosamine, glycated albumin, and serum albumin were measured in 2009 in stored serum samples with a Roche Modular P800 system (Roche Diagnostics) (26 (link)). Glycated albumin was calculated as a percentage of total albumin: {[(glycated albumin concentration in g/dL/serum albumin concentration in g/dL)/1.14] × 100} + 2.9.
Loomis S.J., Chen Y., Sacks D.B., Christenson E.S., Christenson R.H., Rebholz C.M, & Selvin E. (2017). Cross-sectional Analysis of AGE-CML, sRAGE, and esRAGE with Diabetes and Cardiometabolic Risk Factors in a Community-Based Cohort. Clinical chemistry, 63(5), 980-989.
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4

Glycemic Biomarkers in Long-Term Samples

Cited 3 times
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Serum glucose was measured in fresh samples at visit 2 using the hexokinase method. HbA1c was measured in whole blood samples collected at visit 2 stored at −80 Celsius degrees using high-performance liquid chromatography with instruments standardized to the Diabetes Control and Complications Trial assay (Tosoh A1c 2.2. Plus Glycohemoglobin in 2003–2004 and Tosoh G7 analyzers 2007–2008) [17 (link)]. Fructosamine (Roche Diagnostics Corp, Indianapolis, IN, USA), glycated albumin (Asashi Kasei Lucica GA-L, Tokyo, Japan), and 1,5-AG (GlycoMark, Winston-Salem, NC) were measured in 2012–2013 in stored frozen serum using a Roche Modular P800 system [14 (link),18 (link)]. Previous studies have shown these analytes to be reliable in long-term stored samples [19 –21 (link)].
Ding N., Kwak L., Ballew S.H., Jaar B., Hoogeveen R.C., Ballantyne C.M., Sharrett A.R., Folsom A.R., Heiss G., Salameh M., Coresh J., Hirsch A.T., Selvin E, & Matsushita K. (2018). Traditional and nontraditional glycemic markers and risk of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis, 274, 86-93.
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5

Whole Body Composition Analysis by DXA

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In order to estimate whole body composition, DXA scanner (Hologic, Discovery A, Version 4.2) was used. The fat and lean mass was assessed using the APEX software available in the DXA console. Fasting and post prandial blood samples were analysed for blood glucose, glycosylated haemoglobin (HbA1c) and lipid profile. Glucose was measured by the glucose oxidase-peroxidase method (% CV 3.6). Total cholesterol, low density lipoprotein cholesterol (LDL) and serum triglycerides were measured using enzymatic oxidation and absorbance method as per manufacturers’ instructions in enzymatic assay kits supplied by Roche, on Roche Modular P 800 system.
Livingstone R.S., Thomas A.J., Dasgupta R., Anoop S., Kurian M.E., Hawkins M, & Thomas N. (2020). Significance of single and multi-voxel 1H magnetic resonance spectroscopy in the quantification of myocellular lipid in young non-obese Asian Indian males. Magnetic resonance imaging, 75, 65-71.
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6

Reliable 1,5-AG Measurement in Stored Samples

Cited 1 time
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1,5-AG (GlycoMark, Winston-Salem, NC) was measured using a Roche Modular P800 system in 2012–2013 in stored serum specimens obtained at ARIC visit 2. The interassay CV was 5%. The reliability coefficient for N = 610 masked duplicate specimen pairs was 0.99. Previous studies have shown this 1,5-AG assay to be highly reliable even in long-term stored samples (8 (link),36 (link)).
Selvin E., Rawlings A., Lutsey P., Maruthur N., Pankow J.S., Steffes M, & Coresh J. (2015). Association of 1,5-Anhydroglucitol With Cardiovascular Disease and Mortality. Diabetes, 65(1), 201-208.
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7

Thyroid and Vitamin D Status Assessment

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For all subjects, body mass index (BMI) was calculated as weight (kg)/(height (m)2). After fasting overnight for 10–12 h, blood samples were collected for the following measurements: 25(OH) vitamin D, FT3, FT4, TSH, TG-Ab, TPO-Ab, hepatic and renal chemistries. Subjects with elevated TG-Ab and/or TPO-Ab serum levels performed thyroid ultrasound in order to confirm the diagnosis of AT.
Serum levels of 25(OH) vitamin D were determined through electrochemiluminescence binding assay using the Cobas analyzer (Roche Diagnostics) [13 (link)]. Serum TSH, FT3 and FT4 levels were measured by means of electrochemiluminescence immunoassay (Roche Diagnostics). TG-Ab and TPO-Ab measurements were undertaken by electrochemiluminescence immunoassay methods using the Cobas analyzer (Roche Diagnostics). Modular P800 system (Roche Diagnostics) was used for evaluation of creatinine, aspartate aminotransferase, alanine aminotransferase, glucose, total cholesterol and triglycerides.
Muscogiuri G., Mari D., Prolo S., Fatti L.M., Cantone M.C., Garagnani P., Arosio B., Di Somma C, & Vitale G. (2016). 25 Hydroxyvitamin D Deficiency and Its Relationship to Autoimmune Thyroid Disease in the Elderly. International Journal of Environmental Research and Public Health, 13(9), 850.
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8

Arterial Blood Gas and Serum Electrolyte Analysis

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Arterial blood gas is a method to detect the saturation level of oxygen in the patient's blood, which was analyzed with a Rapidlab 860 blood gas analyzer (Bayer AG, Leverkusen, Germany), including pH, partial pressure of arterial oxygen (PaO2), and partial pressure of arterial carbon dioxide (PaCO2). The primary ions of serum electrolytes are sodium (Na+), potassium (K+), calcium (Ca2+), magnesium (Mg2+), chloride (Cl–), hydrogen phosphate (HPO42–), and hydrogen carbonate (HCO3−), which are involved in fluid balance and blood pressure control. Serum electrolyte levels were studied using a Modular P800 system (Roche Diagnostics, Basel, Switzerland), including Na+, K+, Cl−, and HCO3−.
Wang Y., Liu N, & Zhang Z. (2019). Respiratory electrophysiologic studies in chronic obstructive pulmonary disease. Medicine, 98(1), e13993.
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9

Glycated Albumin Measurement Protocol

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Fasting blood samples were drawn from patients within 24 ± 12 h after randomization and immediately frozen at −80°C. All samples from the various study centers were transported to Beijing Tiantan Hospital through a cold chain. The GA assay (catalog number 4085-717, Ruiyuan Bio-Technique Co. Ltd., Ningbo, China) was performed using a Roche Modular P800 system (Roche, Basel, Switzerland) in the clinical laboratory of Beijing Tiantan Hospital [13 (link)]. The GA level was expressed as a percentage of GA in total serum albumin. The interassay coefficient of variation was 2%. All testing personnel were blinded to the study protocol, group assignments, and clinical data.
Zhou H., Pan Y., Chen W., Suo Y., Yan H., Meng X., Zhao X., Liu L., Li H, & Wang Y. (2023). Smokers with Elevated Glycated Albumin Could Not Benefit from Dual Antiplatelet Therapy after Minor Stroke or Transient Ischemic Attack. Cerebrovascular Diseases (Basel, Switzerland), 53(2), 144-151.
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10

Glycated Albumin and Fructosamine Measurement

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Both Fructosamine and glycated albumin were measured from serum samples collected at visit 2 (1990–1992). Samples were stored at −70°C. Fructosamine (Roche Diagnostics, Indianapolis IN, USA) and glycated albumin (GA-L Asashi Kasei Pharma Corporation, Tokyo, Japan) were measured in 2012–2013 using a Roche Modular P800 system. In this study, glycated albumin was expressed as percent glycated albumin: [(glycatedalbuminconcentration(g/dL)/serumalbuminconcentration(g/dL))×100/1.14]+2.9 .
Ray D., Loomis S.J., Venkataraghavan S., Tin A., Yu B., Chatterjee N., Selvin E, & Duggal P. (2023). Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study. medRxiv.
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