FDG and FLT PET/CT were performed on separate and consecutive days. No antitumor treatment was allowed either between or before PET/CT scans. Each patient fasted for at least 8 hours before PET/CT scanning. Blood glucose level recorded prior to scanning was in the normal range. Patients were injected intravenously with FDG or FLT, rested in a quiet room for 1 hour, and then an FDG or FLT PET/CT scan was acquired on an integrated PET/CT scanner (GEMINI TF Big Bore PET/CT; Philips, Amsterdam, The Netherlands). Oral or intravenous contrasts were not performed in patients. The low-dose CT (140 kV, 90 mA, pitch 0.75, 2.5-mm slice thickness, matrix of 512 × 512) was acquired from the skull base to mid-thigh of patients for attenuation correction followed by the whole-body PET scan (3 min per bed position). The PET scans were acquired in 3-D mode in a 512 × 512 matrix and a 2.5 mm slice thickness. Patients lied flat within the body frame on the scanning bed. Marks were made on the body frame and the skin of patients to make sure the repeatability of 2 PET/CT scans. Holding on the scanning position with quiet respiration were required during PET/CT scanning to ensure the quality of images. Images were then reconstructed by attenuation-weighted ordered-subset expectation maximization algorithm (2 iterations, 30 subsets) followed by a postreconstruction smoothing Gaussian filter.
Gemini tf big bore pet ct
Manufactured by Philips
Sourced in United States
The GEMINI TF BIG BORE PET/CT is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to capture high-quality images of the human body for diagnostic and treatment planning purposes.
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7 protocols using gemini tf big bore pet ct
1
Multimodal Imaging: FDG and FLT PET/CT
2
Automated Synthesis and Evaluation of 68Ga-PSMA PET Imaging
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Glu-NH-CO-NH-Lys(Ahx)-HBED-CC was labeled with 68GaCl3 by using a fully automated synthesis module according to Good Laboratory Practice (Eckert & Ziegler, Germany) in combination with sterile single-use cassettes. The radiochemical purity of the final product was ≥97 % and the decay-corrected yield was >95 %.
The patients fasted for at least 4 hours before the intravenous injection of the radiopharmaceutical and were asked to void before starting the PET scan. Mean injected activity of 68Ga-PSMA was 177 ± 37 MBq. At 1 hour post injection, patients underwent a whole body PET scan. Scans were either performed with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare, USA), which provide virtually identical image characteristics 31 . To further optimize comparability of the quantitative measurements both scanners were cross-calibrated. The spatial resolution of the reconstructed PET scan is about 7 mm (full width half maximum, FWHM) for both scanners. A contrast-enhanced diagnostic CT (120 kVp, 100 - 400 mAs, dose modulation) or a low-dose CT (120 kVp, 25 mAs) for attenuation correction (depending on previous CT scans and contraindications) was performed. The accumulation of 68Ga-PSMA-HBED-CC was quantified by standardized uptake values (SUV, regional tracer concentration normalized by injected dose and body weight).
The patients fasted for at least 4 hours before the intravenous injection of the radiopharmaceutical and were asked to void before starting the PET scan. Mean injected activity of 68Ga-PSMA was 177 ± 37 MBq. At 1 hour post injection, patients underwent a whole body PET scan. Scans were either performed with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare, USA), which provide virtually identical image characteristics 31 . To further optimize comparability of the quantitative measurements both scanners were cross-calibrated. The spatial resolution of the reconstructed PET scan is about 7 mm (full width half maximum, FWHM) for both scanners. A contrast-enhanced diagnostic CT (120 kVp, 100 - 400 mAs, dose modulation) or a low-dose CT (120 kVp, 25 mAs) for attenuation correction (depending on previous CT scans and contraindications) was performed. The accumulation of 68Ga-PSMA-HBED-CC was quantified by standardized uptake values (SUV, regional tracer concentration normalized by injected dose and body weight).
3
Quantitative 68Ga-PSMA-HBED-CC PET/CT Imaging
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PET/CT scans using the ligand 68Ga-HBED-CC-PSMA [12 (link)] were either performed with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare. USA). A detailed description of our 68Ga-HBED-CC-PSMA PET/CT imaging protocol is given in our previous publication [13 (link)]. To ensure the comparability of the quantitative measurements, both imaging systems were cross-calibrated. Patients underwent the whole-body PET scan starting 1 h after injection. The uptake of 68Ga-PSMA-HBED-CC was quantified by standardized uptake values (SUV).
4
PET/CT Imaging Protocol Optimization
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In vivo PET/CT scans were acquired either on a 64-channel GEMINI TF PET/CT or on a 16-channel GEMINI TF BIG BORE PET/CT (both Philips Healthcare, Cleveland, OH, PET pixel size x,y,z: 2 × 2 × 2 mm) which provide virtually identical image characteristics [12 ]. To ensure comparability of the measurements, the two scanners were cross-calibrated. At the time of the PET scan, a contrast-enhanced diagnostic CT (120 kVp, 100–400 mAs, dose modulation, pixel size x,y,z: 1.172 × 1.172 × 2 mm) was performed.
5
Radiolabeling and PET Imaging of PSMA-HBED-CC
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Radiolabelling of PSMA-HBED-CC with 68GaCl3 was done using a fully automated synthesis module (Eckert & Ziegler, Germany) in combination with sterile single-use cassettes. The decay-corrected yield was >95% and the radiochemical purity of the final product was ≥97%.
The patients fasted for at least 4 hours before the administration of the radiopharmaceutical and were asked to void before starting the PET scan. 1 hour post injection, patients underwent the whole body PET scan. Scans were either performed with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare, USA, pixel size 2x2x2 mm). Both scanners were cross-calibrated to ensure the comparability of the quantitative measurements. At the time of the PET scan, a contrast-enhanced diagnostic CT (120 kVp, 100-400 mAs, dose modulation, pixel size 1.172x1.172x2 mm) or a low-dose CT (120 kVp, 25 mAs, pixel size 1.172x1.172x2 mm) for attenuation correction (depending on previous CT scans and contraindications) was performed. The uptake of 68Ga-PSMA-HBED-CC was quantified using standardized uptake values (SUV).
The patients fasted for at least 4 hours before the administration of the radiopharmaceutical and were asked to void before starting the PET scan. 1 hour post injection, patients underwent the whole body PET scan. Scans were either performed with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare, USA, pixel size 2x2x2 mm). Both scanners were cross-calibrated to ensure the comparability of the quantitative measurements. At the time of the PET scan, a contrast-enhanced diagnostic CT (120 kVp, 100-400 mAs, dose modulation, pixel size 1.172x1.172x2 mm) or a low-dose CT (120 kVp, 25 mAs, pixel size 1.172x1.172x2 mm) for attenuation correction (depending on previous CT scans and contraindications) was performed. The uptake of 68Ga-PSMA-HBED-CC was quantified using standardized uptake values (SUV).
6
Multiparametric Imaging for Prostate Cancer
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MR images were acquired either on a 3 Tesla or on a 1.5 Tesla system. All systems were equipped with a surface phased array in combination with an integrated spine array coil. No endo-rectal coil was used. Essentially, T2-weighted fast spin echo (T2w-TSE) images, diffusion weighted images (DWI) and dynamic contrast-enhanced (DCE) perfusion images were acquired. A detailed description of the MR imaging protocol is given in [13 (link)]. In case of multiple mpMRI scans before the treatment the last scan prior RT was selected for analysis.
Radiolabelled tracers targeting the prostate specific membrane antigen (PSMA) have been used for detection and delineation of intraprostatic tumour. PET/CT scans were performed one hour after injection of the ligand 68Ga-HBED-CC-PSMA [14 (link)] with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare. USA). Both imaging systems were cross-calibrated. A detailed description of our 68Ga-HBED-CC-PSMA PET/CT imaging protocol is given in [13 (link)].
Prior to EBRT 131 (95%) patients received mpMRI and 36 (26%) patients received PSMA PET/CT scans. Twenty-nine patients (21%) had both.
Radiolabelled tracers targeting the prostate specific membrane antigen (PSMA) have been used for detection and delineation of intraprostatic tumour. PET/CT scans were performed one hour after injection of the ligand 68Ga-HBED-CC-PSMA [14 (link)] with a 64-slice GEMINI TF PET/CT or a 16-slice GEMINI TF BIG BORE PET/CT (both Philips Healthcare. USA). Both imaging systems were cross-calibrated. A detailed description of our 68Ga-HBED-CC-PSMA PET/CT imaging protocol is given in [13 (link)].
Prior to EBRT 131 (95%) patients received mpMRI and 36 (26%) patients received PSMA PET/CT scans. Twenty-nine patients (21%) had both.
7
PET/CT Protocol for FDG Imaging
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A total of 677 patients were examined using a Philips GEMINI TF Big Bore PET/CT. 18F-FDG was produced by a cyclotron in the nuclear department, and its radiochemical purity was greater than 95%. After patients had fasted for more than 6 h, 3.7 MBq/kg (0.1 mCi/kg) 18F-FDG was injected into a vein. The patients were asked to drink water (1500–2000 mL), and imaging commenced after 1 hour. The CT scans were taken from the cranial crest to the upper femur, at 120 kVp and 100 mAs, with a 512 × 512 matrix, a pitch of 0.75, and a layer thickness of 4.25 mm. PET images were collected with the same layer thickness and a 128 × 128 matrix every 2 min per bed. Next, with the patient maintaining his/her position, a deep inspiratory HRCT scan was performed using 64 × 1.25 mm detectors. PET images were reconstructed and fused using a Philips station.
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