Mrl lpr

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MRL/lpr is a laboratory mouse model used in research. It exhibits spontaneous development of systemic lupus erythematosus-like autoimmune disease.

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MRL/lpr mice (27 citations) MRL/MpJ-Faslpr/J (MRL/lpr) mice (4 citations) B6.MRL-Fas lpr /J (B6.lpr) mice (3 citations) MRL/MpJFASlpr (MRL/lpr) mice (3 citations) MRL/Faslpr/lpr ( (2 citations) B6.MRL/lpr (2 citations) MRL/MpJ-Tnfrsf6lpr (MRL/lpr), (2 citations) MRL/Mp-Faslpr (MRL/lpr, (2 citations) OfB6.MRL-Faslpr/J(Faslpr/lpr) mice (2 citations) MRL-Lpr (no. 00485) (2 citations)

28 protocols using mrl lpr

Neurobehavioral Phenotype in MRL/lpr Mice

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The 8–10–week-old MRL/lpr (stock # 000485) and MRL/+ (stock # 000486) mice were purchased from The Jackson Laboratories (Bar Harbor, ME, USA). Female mice were used unless otherwise specified. NPSLE manifestations are absent in the congenic MRL/+ strain and more prominent in female than in male MRL/lpr mice (18 (link), 19 (link)), and CP infiltrating T cells were found to be rare or diminished in the non-autoimmune control MRL/+ strain and in age matched male MRL/lpr mice, respectively (see below). Hence, MRL/+ or male MRL/lpr mice were used as controls in some experiments. Mice were housed in the animal facility of Albert Einstein College of Medicine until they were 16–18 weeks of age, at which time the MRL/lpr strain exhibits a profound neurobehavioral phenotype including cognitive deficits and depressive like behavior (20 (link)–22 (link)). All animal studies were performed under protocols approved by the Institutional Animal Care and Use Committee of the Albert Einstein College of Medicine.

Jain S., Stock A., Macian F, & Putterman C. (2018). A Distinct T Follicular Helper Cell Subset Infiltrates the Brain in Murine Neuropsychiatric Lupus. Frontiers in Immunology, 9, 487.

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Genetic Regulation of Autoimmune Disorders

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All animal experiments and methods of euthanasia were approved by the Ralph H. Johnson VAMC Institutional Animal Care and Use Committee (IACUC). Mice were housed and maintained under pathogen-free conditions at the Ralph H. Johnson VAMC Animal Care Facility (Charleston, SC). MRL/lpr Fli1^+/+ and Fli1^+/− mice (6 (link)) and C57BL/6 Fli1^+/+ and Fli1^+/− mice (16 (link)) were obtained from matings between Fli1^+/+ and Fli1^+/− mice within each strain in our colony. Wild-type MRL/lpr and C57BL/6 Fli1^+/+ mice obtained from Jackson Laboratories (Bar Harbor, ME) were used for matings every other generation to avoid genetic drift in the colonies. Age-matched animals of both genders were used in experiments.

Sundararaj K.P., Thiyagarajan T., Molano I., Basher F., Powers T.W., Drake R.R, & Nowling T.K. (2015). FLI1 levels impact CXCR3 expression and renal infiltration of T cells and renal glycosphingolipid metabolism in the MRL/lpr lupus mouse strain. Journal of immunology (Baltimore, Md. : 1950), 195(12), 5551-5560.

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Decoding Lupus Pathogenesis in Mice

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Female MRL/lpr, Camk4^tmlTch/J and MRL/MpJ mice were purchased from The Jackson Laboratory. MRL/lpr.camkiv^−/− mice were generated on an MRL/lpr background as described previously (7 (link),19 (link)). Experiments were approved by the Institutional Animal Care and Use Committee of Beth Israel Deaconess Medical Center. Kidneys from 16-week-old MRL/MpJ, MRL/lpr, and MRL/lpr.camkiv^−/− mice were formalin-fixed, paraffin-embedded [FFPE] sections that were assessed for in situ hybridization.

Ichinose K., Ushigusa T., Nishino A., Nakashima Y., Suzuki T., Horai Y., Koga T., Kawashiri S.Y., Iwamoto N., Tamai M., Arima K., Nakamura H., Obata Y., Yamamoto K., Origuchi T., Nishino T., Kawakami A, & Tsokos G.C. (2016). Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function. Arthritis & rheumatology (Hoboken, N.J.), 68(4), 944-952.

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Genetically Engineered Mouse Models for Immunological Research

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C57BL/6J, CD4^cre (B6.Cg-Tg(Cd4-cre)1Cwi/BfluJ), Mb1^cre (B6.C(Cg)-Cd79a^tm1(cre)Reth/EhobJ), MRL/lpr (MRL/MpJ-Fas^lpr/J), SLE¹²³ (B6;NZM-Sle1^NZM2410/Aeg Sle2^NZM2410/Aeg Sle3^NZM2410/Aeg/LmoJ), and Rosa26^eYFP (B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/J) mice were obtained from The Jackson Laboratory (Bar Harbor, ME). T-bet-cre^ERT2 mice were generated by Dr. Lin Gan at the University of Rochester, Rochester, NY. Adora2a^flox (B6;129-Adora2a^tm1Dyj/J) mice were provided by Dr. Joel Linden, La Jolla Institute for Immunology, La Jolla, CA. All mice, except for the MRL/MpJ-Fas^lpr/J, were on the C57BL/6J background. All mice were housed and bred in the SUNY Upstate Medical University Animal Care Facility (Syracuse, NY), in accordance with institutional guidelines for animal welfare. All mice used for experiments were at least 6 weeks old, and both male and female mice were used unless otherwise stated. All studies involving animals were approved by the SUNY Upstate Medical University Institutional Animal Care and Use Committee NYSDOH Unit A073 IACUC number 311.

Levack R.C., Newell K.L., Cabrera-Martinez B., Cox J., Perl A., Bastacky S.I, & Winslow G.M. (2022). Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity. Nature Communications, 13, 452.

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MRL/lpr Mice Breeding and Care

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The breeding pairs of MRL/lpr and background matched control MRL/MpJ mice were purchased from Jackson Laboratory (Bar Harbor, ME, USA). This study was reviewed and approved by the Institutional Animal Care and Use Committee of Samsung Biomedical Research Institute (SBRI) in Samsung Medical Center (20140915001). SBRI is accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International and abides by the guidelines of the Institute of Laboratory Animal Resources.

Choi E.W., Lee M., Song J.W., Kim K., Lee J., Yang J., Lee S.H., Kim I.Y., Choi J.H, & Seong J.K. (2020). Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning. Scientific Reports, 10, 12001.

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Diverse Mouse Strains for Comprehensive Research

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For this study, adult female mice from the following four standard inbred strains were used: C57BL/6 J (The Jackson Laboratory, Bar Harbor, ME, USA); B6.129S6(Cg)-Spp1^tm1Blh/J, also known as OPN−/− (The Jackson Laboratory); B6.129P2-Icos/J also know as ICOS−/− (The Jackson Laboratory), BALB/cOlaHsd, or BALB/c mice (Envigo, Huntingdon, UK); and MRL/MpJ-Fas^lpr/J, commonly known as MRL-lpr (The Jackson Laboratory). Mice of the first four strains were used at 8–10 weeks of age, while those of the latter strain were 12 weeks old. All animals were maintained under pathogen-free conditions in the animal facility of Università del Piemonte Orientale; they were fed ad libitum on rodent chow and water was freely available in the home cages, the ambient temperature was maintained at 21 ± 1 °C. All experimental procedures were conducted during the light phase of a 12:12-h light:dark cycle. Experimental procedures were conducted, following European guidelines, in accordance with both the University Ethical Committee and the National Institutes of Health Ministry and Care Committee (protocol number DB064.42), both of which approved the protocol.

Raineri D., Dianzani C., Cappellano G., Maione F., Baldanzi G., Iacobucci I., Clemente N., Baldone G., Boggio E., Gigliotti C.L., Boldorini R., Rojo J.M., Monti M., Birolo L., Dianzani U, & Chiocchetti A. (2020). Osteopontin binds ICOSL promoting tumor metastasis. Communications Biology, 3, 615.

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Genetically Modified Mouse Models

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DsRed B6, OT1 B6, Cd45.1 B6, OT-II B6, Thy1.1 B6, m-OVA B6, Rag1^−/− B6, Il17a-GFP, Aire^−/− B6, B6.lpr, MPJ, MRL.lpr mice were obtained from The Jackson Laboratories. Two-month-old female mice were used unless the age and sex were otherwise specified. All mice were maintained under specific pathogen-free conditions, and all procedures were approved by the Institutional Animal Care Committee of Beth Israel Deaconess Medical Center, Harvard Medical School.

Li H., Adamopoulos I.E., Moulton V.R., Stillman I.E., Herbert Z., Moon J.J., Sharabi A., Krishfield S., Tsokos M.G, & Tsokos G.C. (2020). Systemic lupus erythematosus favors the generation of IL-17 producing double negative T cells. Nature Communications, 11, 2859.

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Autoimmune Disease Mouse Models

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Congenic control (C57BL/6 or B6), Mrl-lpr, Ctnnbfl/fl [25 (link)], and Lyz-M-Cre [26 (link)] mice were purchased from the Jackson Laboratory (Bar Harbor, ME) or Taconic Farms (Hudson, NY). B6.Sle1 [27 (link)], B6.Sle3 [28 (link)], B6.Yaa [29 (link)], and BWF1 [30 (link)] mice were bred in our mouse colony. Mice used for this study were 3 to 13 month females or—in the case of mice harboring the Yaa locus and their controls—males maintained in a specific pathogen-free environment. Mice were euthanized using a CO2 chamber and cervical dislocation. The Institutional Animal Care and Use Committee at the University of Texas Southwestern Medical Center approved all experiments on mice.

Orme J.J., Du Y., Vanarsa K., Wu T., Satterthwaite A.B, & Mohan C. (2016). Leukocyte Beta-Catenin Expression Is Disturbed in Systemic Lupus Erythematosus. PLoS ONE, 11(8), e0161682.

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Mouse Strains for Lupus Research

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NZB, NZW, NZM2410, MRL-lpr, MRL/Mp, B6.NZM^Sle1/2/3, C57BL/6, BXSB/Mp, and BXSB.B6-Yaa mice were purchased from Jackson Laboratories (Bar Harbor, ME, USA). All animals were bred at the animal facility of Renji Hospital, School of Medicine, Shanghai Jiao Tong University. The NZB/W F1 strain was generated by breeding male NZW and female NZB mice. We used the commonly used C57BL/6 mice as a reference strain, and all statistical analyses were based on comparisons with C57BL/6 mice in this study unless otherwise indicated.

Zhou Z., Ma J., Xiao C., Han X., Qiu R., Wang Y., Zhou Y., Wu L., Huang X, & Shen N. (2016). Phenotypic and functional alterations of pDCs in lupus-prone mice. Scientific Reports, 6, 20373.

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Murine Models for Immune Regulation

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C57BL/6 mice were purchased from the Animal Center of Nanjing Medical University. B6.MRL/lpr and TLR4^−/− mice were purchased from the Model Animal Research Center of Nanjing University (Nanjing China). FcγRIIB^−/−, FcγRIII^−/− and MRL/lpr mice were purchased from Jackson Laboratories (Bar Harbor, ME, USA). Mice of 6 to 8 weeks old were used in all the experiments. All mice were housed within the Animal Center of Nanjing Medical University and Tongji Medical College. Protein G agarose was purchased from HyClone.

Qiao W., Ding H., Zuo Y., Jiang L., Zhou J., Han X., Yu L., Du R., M Hedrich C, & Deng G. (2020). Lupus IgG deposition causes arthritis but inhibits bone destruction through competitive occupation of FcγRI and reduced RANKL signalling. Clinical & Translational Immunology, 9(9), e1174.

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