B fc 1000 radiation detector

All solvents and reagents were commercially available and used without further purification unless otherwise stated. NMR spectra were recorded with a Varian 400 MHz instrument at room temperature with tetramethylsilane (TMS) as an internal standard. Mass spectra were performed on an Agilent Q-TOF HPLC-MS or VG (Micromass) 70-250-S Magnetic sector mass spectrometer employing the electrospray ionization (ESI) method or electron ionization (EI) method. High performance liquid chromatography (HPLC) was performed using a Shimadzu LC-2010A HT system equipped with a Bioscan B-FC-1000 radiation detector. All procedures including anhydrous solvents were performed with rigorously dried glassware under inert atmosphere.