Human liver sections from normal controls (collected as part of liver cholangiocarcinoma resection and considered non-diseased areas) and PSC patients treated with placebo or UDCA (15mg/kg/BW) were utilized (Supplemental Table 1 ). PSC patients presented with a range of early to late PSC as described in our previous work5 (link). Liver sections (4-5 μm thick) obtained by needle biopsies from three control patients, three early stage PSC (with or without cirrhosis) and three early stage PSC patients treated with UDCA (with or without cirrhosis). The de-identified samples were provided by Dr. Pietro Invernizzi under a protocol approved by Humanitas Research Hospital; the protocol was approved by the Central Texas Veteran’s Health Care System Institutional Review Board and Research Development Committee . Using acquired human tissue, H&E was performed to assess liver damage that was evaluated by a blinded pathologist; patient serum ALT levels were assessed via colorimetric analysis with an AbCam ALT kit (ab105134).
Alt kit
Manufactured by Abcam
The AbCam ALT kit is a laboratory assay designed to measure the activity of the enzyme Alanine Aminotransferase (ALT) in biological samples. ALT is an enzyme found primarily in the liver and is often used as a biomarker for liver health.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using alt kit
1
Evaluating UDCA Effects on PSC Progression
2
Evaluating UDCA Effects on PSC Progression
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Human liver sections from normal controls (collected as part of liver cholangiocarcinoma resection and considered non-diseased areas) and PSC patients treated with placebo or UDCA (15mg/kg/BW) were utilized (Supplemental Table 1 ). PSC patients presented with a range of early to late PSC as described in our previous work5 (link). Liver sections (4-5 μm thick) obtained by needle biopsies from three control patients, three early stage PSC (with or without cirrhosis) and three early stage PSC patients treated with UDCA (with or without cirrhosis). The de-identified samples were provided by Dr. Pietro Invernizzi under a protocol approved by Humanitas Research Hospital; the protocol was approved by the Central Texas Veteran’s Health Care System Institutional Review Board and Research Development Committee . Using acquired human tissue, H&E was performed to assess liver damage that was evaluated by a blinded pathologist; patient serum ALT levels were assessed via colorimetric analysis with an AbCam ALT kit (ab105134).
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