Similarly, Hom mice were administrated of HSA (AlbuRx,10 g/50 ml, CSL Behring) by intraperitoneal injection from P1 to P7, with 5 g/kg/24 h (n = 9). On P8–P9, four of them were randomly received intraperitoneal injection of SnPP (Tocris Bioscience) with dose of 20 mg/kg on P8 and 30 mg/kg on P9. The dosage was modified from previous study (22 (link)). Meanwhile, others were administrated of equivalent volume of PBS instead. Using the same two-step treatment protocol, WT and Het littermates (n = 10) were used as controls.
Alburx
Manufactured by CSL Behring
AlbuRx is a laboratory equipment product manufactured by CSL Behring. It is designed to process and prepare human albumin solutions for various medical applications. The core function of AlbuRx is to efficiently and reliably extract, purify, and concentrate human albumin from plasma samples.
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Lab products found in correlation
28 protocols using alburx
1
Effect of SnPP on Hom Mice
2
Docetaxel-HSA Nanoformulation Preparation
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Example 15
The Ratio by Weight of Docetaxel to HSA Prepared was about 1:160.
Docetaxel (2 mg) was dissolved in methanol (2.7 ml) in a glass vial to give a clear solution. A solution of HSA (320 mg, 1.6 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 4.8 ml of water to give a HSA solution (6.4 ml) in a round bottom flask. The methanol solution of Docetaxel was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The clear water solution was filtered by a 0.22 micron aqueous phase filter. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution.
3
Docetaxel-HSA Nanoparticle Formulation
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Example 18
The Ratio by Weight of Docetaxel to HSA Prepared was about 1:200.
Docetaxel (2 mg) was dissolved in methanol (3.4 ml) in a glass vial to give a clear solution. A solution of HSA (400 mg, 2 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 6 ml of water to give a HSA solution (8 ml) in a round bottom flask. The methanol solution of Docetaxel was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The clear water solution was filtered by a 0.22 micron aqueous phase filter. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution.
4
Preparation and Characterization of Cabozantinib-HSA Conjugate
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Example 22
The Ratio by Weight of Cabozantinib to HSA Prepared was about 1:250.
Cabozantinib (1 mg) was dissolved in methanol (2.1 ml) in a vial to give a clear solution. A solution of HSA (250 mg, 1.25 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 3.8 ml of water to give a HSA solution (5.05 ml) in a round bottom flask. The methanol solution of cabozantinib was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a cloudy solution.
5
Formulating Cabozantinib-HSA Solid Conjugate
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Example 23
The Ratio by Weight of Cabozantinib to HSA Prepared was about 1:300.
Cabozantinib (1 mg) was dissolved in methanol (2.6 ml) in a vial to give a clear solution. A solution of HSA (300 mg, 1.5 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 4.5 ml of water to give a HSA solution (6 ml) in a round bottom flask. The methanol solution of cabozantinib was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution.
6
Albumin-Based Formulation of ABOA
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Example 14
The ratio by weight of ABOA to HSA prepared was about 1:45.
ABOA (4 mg) was dissolved in methanol (1.7 ml) in a vial to give a clear solution. A solution of HSA (180 mg, 0.9 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 3 ml of water to give a HSA solution (3.9 ml) in a round bottom flask. The methanol solution of ABOA was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution. This aqueous solution stays clear with no precipitation after 1 hour, 2 hours, 3 hours, and 24 hours at room temperature.
7
Preparation and Characterization of ABOA-HSA Complex
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Example 12
The ratio by weight of ABOA to HSA prepared was about 1:75.
ABOA (4 mg) was dissolved in methanol (2.6 ml) in a vial to give a clear solution. A solution of HSA (300 mg, 1.5 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 4.5 ml of water to give a HSA solution (6 ml) in a round bottom flask. The methanol solution of ABOA was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution. This aqueous solution stays clear with no precipitation after 1 hour, 2 hours, 3 hours, and 24 hours at room temperature.
8
Preparation and Characterization of ABOA-Albumin Complex
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Example 11
The ratio by weight of ABOA to HSA prepared was about 1:100.
ABOA (4 mg) was dissolved in methanol (3.4 ml) in a vial to give a clear solution. A solution of HSA (400 mg, 2 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 6 ml of water to give a HSA solution (8 ml) in a round bottom flask. The methanol solution of ABOA was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution. This aqueous solution stays clear with no precipitation after 1 hour, 2 hours, 3 hours, and 24 hours at room temperature.
9
Preparation and Characterization of ABOA-HSA Complex
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Example 18
The ratio by weight of ABOA to HSA prepared was about 1:30.
ABOA (4 mg) was dissolved in methanol (1.0 ml) in a vial to give a clear solution. A solution of HSA (120 mg, 0.6 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 1.8 ml of water to give a HSA solution (2.4 ml) in a round bottom flask. The methanol solution of ABOA was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a slightly cloudy solution. This aqueous solution stays slightly cloudy with some white precipitations after 1 hour at room temperature.
10
Preparation of Docetaxel-HSA Nanoparticles
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Example 18
The Ratio by Weight of Docetaxel to HSA Prepared was about 1:200.
Docetaxel (2 mg) was dissolved in methanol (3.4 ml) in a glass vial to give a clear solution. A solution of HSA (400 mg, 2 ml) (20% human serum albumin solution for infusion (product name: AlbuRx) from CSL Behring) was added into 6 ml of water to give a HSA solution (8 ml) in a round bottom flask. The methanol solution of Docetaxel was added slowly dropwise into the flask of the HSA solution with rapid stirring at 0° C. Upon completion of the addition, a clear solution was obtained. Then, the methanol in the solution was removed under vacuum to give a clear solution. The clear water solution was filtered by a 0.22 micron aqueous phase filter. The resulting clear aqueous solution was lyophilized overnight to give a white solid.
A sample of 100 mg of the lyophilized solid was reconstituted by adding 2 mL water to give a clear solution.
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