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Cool b65 a p coil

Manufactured by MagVenture
Sourced in Denmark

The Cool-B65 A/P coil is a lab equipment product designed for magnetic stimulation. It features a figure-of-eight coil configuration with a 65 mm diameter. The coil is actively cooled to maintain consistent performance during operation.

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10 protocols using cool b65 a p coil

1

Transcranial Magnetic Stimulation Protocols

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All TBS protocols were applied to the individual participant’s motor hotspot at 80% of AMT in each participant. The iTBS and cTBS protocols consisted of 600 pulses in total given over 200 s and 40 s time periods correspondingly. The iTBS protocol included trains of 3-pulse bursts (duration of trains 2 s, burst frequency 50 Hz, inter-burst interval 200 ms) spaced by 8 s ITIs. The cTBS protocol used 3 pulse bursts (frequency 50 Hz, inter-burst interval 200 ms) that were delivered continuously. In addition to iTBS and cTBS, each volunteer was randomly assigned to receive either sham iTBS or sham cTBS during the initial visit series, and the same sham stimulation during retest visit series. For administration of the sham TBS protocols, the placebo side of the Cool-B65 A/P coil with a 3D printed 3.3 cm spacer (MagVenture A/S, Farum, Denmark) attached to the placebo side was used. Single positive triangle electrical pulses (pulse width 2.2 ms, intensity 2–3 mA) were given synchronously with TMS and sham TMS for additional blinding of the participants by an attempt to match the sensory experience of the active and sham protocols. For this purpose, a pair of self-adhesive surface electrodes (Ambu Neuroline 715, Ambu A/S Baltorpbakken 13, DK-2750 Ballerup) were placed approximately 1 cm below the inion. The electrical stimulation was applied synchronously with all TBS protocols.
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2

Transcranial Magnetic Stimulation Protocol for Brain Stimulation

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TBS procedures were performed using a figure-of-eight Cool B-65 A/P coil (Magventure). At baseline, individual resting motor threshold was determined using Parameter Estimation by Sequential Training, an automated algorithm used to determine TMS thresholds (22 (link)). The TMS coil was positioned at the FP1 using the standard electroencephalography 10–20 landmark location. TBS was administered at 110% of each participant’s resting motor threshold. Pulses were administered in a burst-firing pattern (3 pulse burst, 50 Hz; 5 Hz [200-ms] interburst intervals; 1800 pulses/train with a 60-second intertrain interval [3600 pulses/day]). To enhance tolerability of FP1 TBS, stimulation intensity was gradually escalated from 30% to 110% of resting motor threshold over the first 30 seconds of each train.
This double-blind study used the MagVenture MagPro integrated active-sham system, wherein a USB key coded with participant numbers was inserted into the machine prior to each participant’s visit and electrodes (Natus Inc.) are placed on the left frontalis muscle under the coil. During stimulation, current was passed through the surface electrodes at an intensity scaled to their motor threshold. Following each TMS treatment, individuals were asked to note whether they received real or sham and their level of confidence (Likert scale, 1–10).
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3

Intermittent Theta Burst Stimulation Protocol

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rTMS was administered using a Magventure MagPro R30 with Cool B65 A/P Coil (figure-8 coil with 65 mm windings) for all sessions in this study. We applied rTMS in both parent studies at the following parameters: 600 pulses of intermittent theta burst (iTBS) stimulation with 50 Hz triplet bursts repeated at 5 Hz (15 pulses per second) for 2s on, 8s off for 192 s iTBS was delivered at 120% resting motor threshold (rMT). rMT was determined on Day 1 of treatment with stimulation over the left motor cortex and visual observation of thumb movements in the right anterior pollicis brevis (APB) muscle in 5 out of 10 trials.
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4

Intermittent Theta Burst Stimulation Protocol

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rTMS was administered using a Magventure MagPro R30 with Cool B65 A/P Coil (figure-8 coil with 65 mm windings) for all sessions in this study. We applied rTMS in both parent studies at the following parameters: 600 pulses of intermittent theta burst (iTBS) stimulation with 50 Hz triplet bursts repeated at 5 Hz (15 pulses per second) for 2s on, 8s off for 192 s iTBS was delivered at 120% resting motor threshold (rMT). rMT was determined on Day 1 of treatment with stimulation over the left motor cortex and visual observation of thumb movements in the right anterior pollicis brevis (APB) muscle in 5 out of 10 trials.
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5

Right dlPFC rTMS During Working Memory

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A Magventure MagPro 100 (MagVenture, Inc., Alpharetta GA) stimulator equipped with a Cool-B65 A/P coil was used to deliver the rTMS to the right dlPFC target defined above. Subjects received a total of 42, four-second trains of 10 Hz stimulation during the WM delay period (jittered 3–5 s after delay onset) starting at 100% MT. Intensity was lowered upon request of the subject to avoid non-specific effects of the sensation of the TMS pulse on subjects’ anxiety. Subjects’ final intensity was ~90% MT, and did not differ between active and sham (Active: M = 89.0 %MT, SD = 13.5; Sham: M = 91.6 %MT, SD = 13.0; p > 0.05). Similarly, subjects’ intensity ratings (1[not unpleasant]−10 [extremely unpleasant]) did not differ between active and sham (Active: M = 6.3, SD = 2.4; Sham: M = 5.1, SD = 2.2; p > 0.05).
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6

Sham-controlled Transcranial Magnetic Stimulation

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TBS was applied to the motor hotspot at 80% of AMT. All TBS protocols were delivered as 3 pulse bursts at 50 Hz with 200 ms between bursts (600 pulses total). This pattern was delivered continuously in cTBS and in a 2 sec–on, 8 sec–off pattern for iTBS. Participants were randomly assigned to receive either sham using either the cTBS or iTBS pattern, which was maintained across both sham visits. Sham cTBS and iTBS protocols were administered on the motor hot spot from the placebo side of the Cool-B65 A/P coil with a 3D printed 3 cm spacer additionally attached to the placebo side (MagVenture A/S, Farum, Denmark). Both active and sham-TBS protocols also included delivery of weak current pulses (between 2 and 4 mA and proportional to the intensity of actual TMS pulse) via surface electrodes (Ambu Neuroline 715 12/Pouch) placed approximately 1 cm below the inion bump and synchronized with the TBS trains to produce scalp sensations during both active and sham TBS conditions. This was done with the intention of blinding participants as to what kind of stimulation they were receiving when the direct somatosensory sensations of active TBS were not present during the sham stimulation.
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7

Sham-controlled Transcranial Magnetic Stimulation

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TBS was applied to the motor hotspot at 80% of AMT. All TBS protocols were delivered as 3 pulse bursts at 50 Hz with 200 ms between bursts (600 pulses total). This pattern was delivered continuously in cTBS and in a 2 sec–on, 8 sec–off pattern for iTBS. Participants were randomly assigned to receive either sham using either the cTBS or iTBS pattern, which was maintained across both sham visits. Sham cTBS and iTBS protocols were administered on the motor hot spot from the placebo side of the Cool-B65 A/P coil with a 3D printed 3 cm spacer additionally attached to the placebo side (MagVenture A/S, Farum, Denmark). Both active and sham-TBS protocols also included delivery of weak current pulses (between 2 and 4 mA and proportional to the intensity of actual TMS pulse) via surface electrodes (Ambu Neuroline 715 12/Pouch) placed approximately 1 cm below the inion bump and synchronized with the TBS trains to produce scalp sensations during both active and sham TBS conditions. This was done with the intention of blinding participants as to what kind of stimulation they were receiving when the direct somatosensory sensations of active TBS were not present during the sham stimulation.
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8

High-Frequency rTMS for Depression Remission

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The published stimulation protocol [15 (link),16 (link)] is described in the Supplement (eMethods: TMS Details). Briefly, the rTMS device was a MagPro R30 stimulator with a Cool-B65-A/P coil (MagVenture, Farum, Denmark). This coil was enabled with an integrated sham mechanism that kept the entire site blinded to patient treatment assignment. Both active and sham conditions received transcutaneous electrical nerve stimulation on the forehead to simulate muscle contractions induced by stimulation of the frontal lobe. Patients listened to simulated stimulator noise through earphones. Stimulation was delivered 6 cm anterior to the motor hot spot (eMethods: Motor Hot Spot and Threshold/Dosage) with the coil oriented 45° relative to midline with the coil handle pointing posterior to the patient and lateral (i.e. away from midline). Each patient had a cloth cap marked with the treatment location (MagVenture, Farum, Denmark) for re-use by treaters to consistently position the treatment coil. RTMS treatment (10 Hz frequency, 4 s on, 10 s off, 120% motor threshold, 4000 pulses/session, 25 min per session) was delivered daily in blocks of 5 for a minimum of 20 sessions (80,000 pulses) and a maximum of 30 sessions (120,000 pulses) depending on whether the patient reached remission (24 item Hamilton Rating Scale for Depression score<11).
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9

High-Frequency rTMS for Depression Remission

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The published stimulation protocol [15 (link),16 (link)] is described in the Supplement (eMethods: TMS Details). Briefly, the rTMS device was a MagPro R30 stimulator with a Cool-B65-A/P coil (MagVenture, Farum, Denmark). This coil was enabled with an integrated sham mechanism that kept the entire site blinded to patient treatment assignment. Both active and sham conditions received transcutaneous electrical nerve stimulation on the forehead to simulate muscle contractions induced by stimulation of the frontal lobe. Patients listened to simulated stimulator noise through earphones. Stimulation was delivered 6 cm anterior to the motor hot spot (eMethods: Motor Hot Spot and Threshold/Dosage) with the coil oriented 45° relative to midline with the coil handle pointing posterior to the patient and lateral (i.e. away from midline). Each patient had a cloth cap marked with the treatment location (MagVenture, Farum, Denmark) for re-use by treaters to consistently position the treatment coil. RTMS treatment (10 Hz frequency, 4 s on, 10 s off, 120% motor threshold, 4000 pulses/session, 25 min per session) was delivered daily in blocks of 5 for a minimum of 20 sessions (80,000 pulses) and a maximum of 30 sessions (120,000 pulses) depending on whether the patient reached remission (24 item Hamilton Rating Scale for Depression score<11).
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10

Neuromodulation of Prefrontal Cortex

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Coil position was determined using standardized coordinates from the International 10–20 system (with Fp1 corresponding to the left VMPFC stimulation target). The location and orientation of each participant’s coil placement was indicated on a nylon cap that participants wore throughout visit 1 and both MRI/rTMS sessions. Participants’ rMT was identified via the standardized Parametric Estimation by Sequential Testing procedure (25 (link)). The cTBS was administered with a figure-of-eight Cool-B65 A/P coil (MagVenture, Farum, Denmark). Participants received two 2-minute trains of cTBS over Fp1 (one train = 120 seconds; three pulse bursts at 5 Hz; 15 pulses/s; 1800 pulses/train; 60-second intertrain interval; 110% rMT) (see Supplemental Methods for details of rigorous active sham). To enhance tolerability, stimulation intensity was gradually escalated in 5% increments (from 80% to 110% rMT) over the first 30 seconds of each train.
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