C7 xr

Manufactured by Abbott

Sourced in United States

The C7-XR is a laboratory equipment product manufactured by Abbott. It is a clinical chemistry analyzer designed for high-throughput testing in diagnostic laboratories. The core function of the C7-XR is to perform automated, quantitative analysis of various analytes in biological samples, such as blood, urine, or other bodily fluids.

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Lab products found in correlation

C7 dragonfly catheter, by Abbott (2 mentions) Lunawave, by Terumo (2 mentions) Axiom artis dta, by Siemens (1 mentions) Dragonfly catheter, by Abbott (1 mentions) Offline proprietary software, by Abbott (1 mentions) Ilumien optis, by Abbott (1 mentions)

8 protocols using c7 xr

Carotid Stenosis Evaluation using DSA and OCT

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A DynaCT angiography scanner (Siemens Axiom Artis dTA, Siemens Healthcare, Erlangen, Germany) was used for the DSA examination. The degree of carotid stenosis was evaluated according to North America Symptomatic Carotid Endarterectomy Trial (NASCET) criteria (Barnett et al., 1998 (link)). Frequency domain OCT systems (ILUMEN OPTIS System or C7-XR, St. Jude Medical, Abbott Vascular, United States) and 2.7-F OCT imaging catheters (C7 Dragonfly Catheter or Dragonfly Duo Catheter, St. Jude Medical, Abbott Vascular, United States) were used for OCT evaluation. The OCT catheter was inserted through an 8-F sheath over the 0.014-inch guidewire of the filter, and advanced distal to the ICA lesion. OCT image was acquired by the injection of 20 mL undiluted iodixanol 320 (GE Healthcare Ireland Limited, County Cork, Ireland) through the guiding catheter at the flow rate of 10 mL/s. Images were calibrated by adjustment of the Z-offset. Automatic pullbacks covered 54 mm of the vessel at a velocity of 20 mm/s or 25 mm/s (Liu et al., 2015 (link)). OCT images were stored and analyzed subsequently using proprietary software (ILUMEN OPTIS System, St. Jude Medical, Abbott Vascular, United States). The DSA and OCT procedures were performed by interventional neurologists with extensive experience in carotid OCT.

Yang Q., Guo H., Shi X., Xu X., Zha M., Cai H., Yang D., Huang F., Zhang X., Lv Q., Liu R, & Liu X. (2021). Identification of Symptomatic Carotid Artery Plaque: A Three-Item Scale Combined Angiography With Optical Coherence Tomography. Frontiers in Neuroscience, 15, 792437.

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Intravascular OCT Imaging of Coronary Arteries

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For intravascular OCT imaging, the imaged artery was perfused with phosphate buffered saline (PBS) and the intracoronary pressure was maintained at 100 mmHg. The OCT image pullbacks of the coronary arteries were performed at 20 mm/s. The OCT system used for imaging was a C7-XR with Dragonfly catheter (St. Jude Medical Inc. St. Paul, MN, USA).The end of the guide catheter served as a reference point.

Gnanadesigan M., Hussain A.S., White S., Scoltock S., Baumbach A., van der Steen A.F., Regar E., Johnson T.W, & van Soest G. (2016). Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study. The International Journal of Cardiovascular Imaging, 33(1), 5-11.

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OCT Analysis of In-Stent Restenosis

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OCT examination was performed using either frequency-domain (C7-XR™ or ILUMIEN™ OPTIS™ OCT Intravascular Imaging System; St Jude Medical) OCT system. During PCI, an OCT catheter (Dragonfly™ or Dragonfly™ Duo™; St. Jude Medical, St. Paul, MN, USA) was used to pass the ISR lesion and contrast agent was injected at a rate of 3–4 mL/s while pullback was performed [9 (link)]. All OCT images were subjected to analysis by two experienced physicians (Mengting Jiang and Yan Han) who were unaware of the patients' clinical and angiographic information. An offline proprietary software (St. Jude Medical) was employed for this image analysis process. When the views of the two observers diverged, a third independent expert assessed the decision. In addition, to evaluate the intra-observer changes in diagnosing OCT features (neointimal pattern properties, backscatter features, ISNA and TCFA), one of the two observers (Yan Han) conducted a re-evaluation of all OCT images four months after concluding the initial OCT image evaluation process.

Yuan X., Jiang M., Feng H., Han Y., Zhang X., Chen Y, & Gao L. (2023). The effect of sex differences on neointimal characteristics of in-stent restenosis in drug-eluting stents: An optical coherence tomography study. Heliyon, 9(8), e19073.

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Cardiac OCT Imaging Protocol

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OCT imaging was performed using either C7XR, OPTIS™ (St-Jude Medical, Westford, MA, United States), or Lunawave (Terumo Corp., Tokyo, Japan) Fourier Domain system. Pullbacks were performed by using either a manual or automatic blood flushing at a constant speed ranging from 18–40 mm/s and frame rate that ranged from 100 to 180 fr/s. The collected data were stored in DICOM format and sent to Barts Heart Centre for analysis.

Jin C., Torii R., Ramasamy A., Tufaro V., Little C.D., Konstantinou K., Tan Y.Y., Yap N.A., Cooper J., Crake T., O’Mahony C., Rakhit R., Egred M., Ahmed J., Karamasis G., Räber L., Baumbach A., Mathur A, & Bourantas C.V. (2022). Morphological and Physiological Characteristics of Ruptured Plaques in Native Arteries and Neoatherosclerotic Segments: An OCT-Based and Computational Fluid Dynamics Study. Frontiers in Cardiovascular Medicine, 9, 890799.

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In-vivo Airway Imaging Using OCT

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OCT images of in-vivo airways were acquired using a C7-XR St. Jude Medical Inc. system interfaced with a C7 Dragonfly catheter (Ø 0.9 mm diameter) (St. Jude Medical Inc., St. Paul, MN, USA). After standard diagnostic bronchoscopy, the OCT catheter was inserted through a guide sheath into the working channel of the bronchoscope into the airways of interest where an automated pullback of 5.4 cm was performed (S1A Fig). All airways in the lobe candidate for surgical resection were imaged from subsegmental to segmental airways. Each pullback was repeated at least two times.

d’Hooghe J.N., Goorsenberg A.W., de Bruin D.M., Roelofs J.J., Annema J.T, & Bonta P.I. (2017). Optical coherence tomography for identification and quantification of human airway wall layers. PLoS ONE, 12(10), e0184145.

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Validating Automated Stent Analysis in OCT

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The image sets used for the validation studies were collected from the database of the Cardiovascular Imaging Core Laboratory, University Hospitals Case Medical Center (Cleveland, OH). These images were collected by commercial Fourier-domam OCT systems (C7XR™, St. Jude Medical Inc., St. Paul, Minnesota), and have been previously analyzed by multiple expert analysts using commercial OCT workstations (St. Jude Medical Inc.) for other purposes. The statistics describing the validation data are listed m Table 1.
There are in total more than 8000 manually analyzed images from 103 pullbacks from 72 patients. The data are from 3 stent types. The data range from baseline to follow-up cases at different time points (note that the true number of images containing stent struts from the 103 pullbacks is more than 10,000, but because of time constraints, not every image was analyzed by human experts). In order to represent the widest possible range of cases that may be encountered in a clinical setting, no images were excluded from the data set for any reason. In particular, in each pullback, every image that had been analyzed by human experts was included in the validation. Therefore, images with different intensity, contrast, collected by different machines and with different artifacts commonly seen in clinical imaging, were included in this large validation set.

Wang Z., Jenkins M.W., Linderman G.C., Bezerra H.G., Fujino Y., Costa M.A., Wilson D.L, & Rollins A.M. (2015). 3-D Stent Detection in Intravascular OCT Using a Bayesian Network and Graph Search. IEEE transactions on medical imaging, 34(7), 1549-1561.

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Plaque Subtyping in NSTEMI Patients

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We compared _pltHYAL2 expression, as described above, within NSTEMI patients by sub-grouping them according to OCT investigation (C7-XR or ILUMIEN OPTIS, St. Jude Medical) in IFC plaques (n = 6) and Ruptured Fibrous Cap (RFC) plaques (n = 8). We classified as plaque erosion the presence of thrombus overlying a plaque with IFC, or the presence of luminal surface irregularity at the culprit lesion in the absence of thrombus, and as RFC the presence of fibrous cap discontinuity with a cavity formed inside the plaque or with a direct communication between lumen and inner core of a plaque⁷ (link).

Vinci R., Pedicino D., D’Aiello A., Ciampi P., Ponzo M., Bonanni A., Russo G., Montone R.A., Massetti M., Crea F, & Liuzzo G. (2021). Platelet hyaluronidase 2 enrichment in acute coronary syndromes: a conceivable role in monocyte-platelet aggregate formation. Journal of Enzyme Inhibition and Medicinal Chemistry, 36(1), 785-789.

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Optimized OCT Imaging for Thrombus Assessment

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OCT imaging was performed with a C7XR, an OPTIS TM (St-Jude Medical, Westford, MA, USA) or a Lunawave (Terumo Corp, Tokyo Japan) Fourier Domain system. In segments with increased thrombus burden, thrombus aspiration was undertaken before OCT imaging. Pull-back was performed with the use of an automated pull-back device at a constant speed (range: 18-40mm/s) during continuous injection of contrast medium (frame rates: 180 fr/s for the OPTIS, 100 fr/s for the C7XR and 160 fr/s for the Lunawave system).

Torii R., Stettler R., Räber L., Zhang Y.J., Karanasos A., Dijkstra J., Patel K., Crake T., Hamshere S., Garcia-Garcia H.M., Tenekecioglu E., Ozkor M., Baumbach A., Windecker S., Serruys P.W., Regar E., Mathur A, & Bourantas C.V. (2018). Implications of the local hemodynamic forces on the formation and destabilization of neoatherosclerotic lesions. International journal of cardiology, 272.

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