Triethylamine tea

Rare earth oxides Y₂O₃ (99.99%), Yb₂O₃ (99.99%), and Er₂O₃ (99.99%) were obtained from China Rare Earth Online Co. Ltd. Rare earth chlorides (LnCl₃, Ln: Y, Gd, Yb, Er) were prepared by dissolving the corresponding oxides in hydrochloric acid and then evaporating the water completely. Ammonium fluoride (NH₄F, 98%), sodium hydroxide, hydrochloric acid, ethanol, methanol, methylene chloride, triethylamine (TEA), and dimethyl sulfoxide (DMSO) were purchased from Sinopharm Chemical Reagent Co., Ltd (China). Oleic acid (OA, 90%), 1-octadecene (ODE, 90%), and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) were purchased from Sigma-Aldrich. Anticancer drug doxorubicin hydrochloride (DOX, > 98%) was purchased from Shanghai Sangon Biotech Company (Shanghai China) and was deprotonated with addition of triethylamine to obtain the hydrophobic form. Carboxyl-terminated Poly(lactide-co-glycolide) (PLGA-COOH 50:50, Mw = 10000) was obtained from Jinan Daigang Bioengineer Company, China. Polyvinyl alcohol (PVA, Mw = 22000) was obtained from Kuraray CO. LTD, Japan. All reagents were used as received without further purification.

Monohydroxy-capped poly(ethylene glycol) (PEG₁₁₃-OH) with a mean degree of polymerization, DP, of 113 (M_n = 5000 g/mol, M_w/M_n = 1.02) was purchased from Aldrich and dried at 30 °C under vacuum overnight prior to use. 2-Diethylaminoethyl methacrylate (DEA, Aldrich, 99%) and styrene (St, Aldrich, 99%) were passed through basic alumina column to remove inhibitor and then vacuum distilled from CaH₂ and stored at − 20 °C prior to use. 2, 2-Bipyridine (bpy), copper bromide (CuBr), 2-bromoisobutyryl bromide, 2-aminoethyl methacrylate hydrochloride (AMA^.HCl), d-glucono-δ-lactone, bortezomib (BTZ), and Alizarin Red S (ARS) were all purchased from J&K and directly used. Methanol, toluene, triethylamine (TEA), 1-methyl-2-pyrrolidinone (NMP), and isopropyl alcohol (IPA) were purchased from Sinopharm Group Chemical Reagent Co., Ltd., and then distilled from CaH₂ under reduced pressure. Dichloromethane, chloroform, dimethyl sulfoxide (DMSO), and other organic solvents were purchased from Sinopharm Group Chemical Reagent Co., Ltd., and directly used without further purification. Bromide terminated poly(ethylene glycol) (PEG₁₁₃-Br) macroinitiator and 2-gluconamidoethyl methacrylate (GAMA) monomer were prepared from PEG₁₁₃-OH and 2-bromoisobutyryl bromide, and AMA^.HCl and d-glucono-δ-lactone, respectively, according to literature procedures [35 (link), 36 (link)].

All chemicals were obtained from the indicated sources. 1,3-Trimethylene carbonate (TMC) was purchased from Daigang Biomaterial Co. Ltd. (Jinan, China), and recrystallized twice with acetic ether and then dried 24 h in a vacuum before polymerization. Stannous octanoate (Sn(Oct)₂) and methoxypolyethylene glycols (mPEG₄₃) were purchased from Aldrich and used without purification. Doxorubicin hydrochloride (DOX·HCl) was purchased from Ark Pharm, Inc. (Arlington Heights, IL, USA) Triethylamine (TEA) was purchased from Sinopharm Chemical Reagent Co., Ltd. (Shenyang, China). Tetrahydrofuran (THF) and toluene were dried by treatment with Na and distilled before use. All other solvents and reagents used were purified by standard methods.