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10 2 5 dihydroxy 3 4 dimethoxy 6 ethylphenyl decyl triphenyl phosphonium monomethanesulfonate mitoquinol or mitoq

Manufactured by Cayman Chemical
Sourced in United States

Cayman Chemical's [10-(2,5-dihydroxy-3,4-dimethoxy-6,ethylphenyl)decyl]triphenyl-phosphonium, monomethanesulfonate (mitoquinol or mitoQ) is a quinone derivative. It functions as an antioxidant and is a mitochondria-targeted compound.

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3 protocols using 10 2 5 dihydroxy 3 4 dimethoxy 6 ethylphenyl decyl triphenyl phosphonium monomethanesulfonate mitoquinol or mitoq

1

Radioligand Binding and Mitochondrial Assay

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[3H]-DTG (29 Ci/mmol) was purchased from PerkinElmer Life Sciences (Zavantem, Belgium), DTG was purchased from Tocris Cookson Ltd. (U.K.) and (+)-Pentazocine was obtained from Sigma-Aldrich-RBI s.r.l. (Milan, Italy). Wistar Hannover rats (250–300 g) were retrieved from Harlan, Italy. Cell culture reagents were purchased from EuroClone (Milan, Italy). MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) was obtained from Sigma-Aldrich (Milan, Italy). [10-(2,5-dihydroxy-3,4-dimethoxy-6,ethylphenyl)decyl]triphenyl-phosphonium, monomethanesulfonate (mitoquinol or mitoQ) was obtained from Cayman Chemical (Ann Arbor, MI, USA).
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2

Evaluation of Anticancer Compounds

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Fetal bovine serum (FBS) and culture medium were from Invitrogen Life Technologies (Carlsbad, CA). Plasticware for cell cultures was from Falcon (Becton Dickinson, Franklin Lakes, NJ). The protein content was assessed with the BCA kit from Sigma Aldrich. (St. Louis, MO). Cis-diammineplatinum (II) dichloride, docetaxel, elesclomol were purchased by Sigma Aldrich. [10-(2,5-dihydroxy-3,4-dimethoxy-6,ethylphenyl)decyl]triphenyl-phosphonium, monomethanesulfonate (mitoquinol or mitoQ) was from Cayman Chemical (Ann Arbor, MI).
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3

Cell Culture Reagents and Compounds

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Fetal bovine serum (FBS) and culture medium were from Invitrogen Life Technologies (Carlsbad, CA). Plasticware for cell cultures was from Falcon (Becton Dickinson, Franklin Lakes, NJ). The protein content was assessed with the BCA kit from Sigma Aldrich. (St. Louis, MO). Cis-diammineplatinum (II) dichloride, docetaxel, elesclomol were purchased by Sigma Aldrich. [10-(2,5-dihydroxy-3,4-dimethoxy-6,ethylphenyl)decyl]triphenyl-phosphonium, monomethanesulfonate (mitoquinol or mitoQ) was from Cayman Chemical (Ann Arbor, MI).
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