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Immunodeficient athymic nude foxn1nu nu mice

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The immunodeficient athymic nude-FoxN1nu/nu mice are a well-established laboratory animal model. They are characterized by a lack of a functional thymus, resulting in a deficiency of T cells. This model is commonly used in biomedical research, particularly in areas such as cancer, immunology, and regenerative medicine.

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2 protocols using immunodeficient athymic nude foxn1nu nu mice

1

Transgenic Murine Models for Research

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Immunodeficient athymic nude-FoxN1nu/nu mice were purchased from Envigo. RB1L mutant mice were maintained on the FVB background and genotyped as published previously (37 (link), 70 (link)). Mice were housed in the Association for Assessment of Laboratory Animal Care-approved McArdle Laboratory Animal Care Unit. All procedures were carried out in accordance with an animal protocol approved by the University of Wisconsin Institutional Animal Care and Use Committee (IACUC; protocol number M005871).
Wei T., Grace M., Uberoi A., Romero-Masters J.C., Lee D., Lambert P.F, & Munger K. (2021). The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis. mBio, 12(4), e02277-21.
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2

Athymic Nude Mouse Xenograft

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Immunodeficient athymic nude-FoxN1nu/nu mice were purchased from Envigo. Mice were housed in the Association for Assessment of Laboratory Animal Care-approved Clinical Sciences Center Vivarium. All procedures were carried out in accordance with an animal protocol approved by the University of Wisconsin Institutional Animal Care and Use Committee (IACUC; protocol number M005871).
Romero-Masters J.C., Grace M., Lee D., Lei J., DePamphilis M., Buehler D., Hu R., Ward-Shaw E., Blaine-Sauer S., Lavoie N., White E.A., Munger K, & Lambert P.F. (2023). MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. PLOS Pathogens, 19(4), e1011215.
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