N-vinylcaprolactam (VCL) and acetoacetoxyethyl methacrylate (AAEM) were obtained from Sigma Aldrich (St. Louis, MO, USA), vacuum distilled under nitrogen and purified by conventional methods. The fluorescent marker rhodamine B, the initiator 2,2-azobis-2-methylpropionamidine dihydrochloride (AMPA) and the cross-linker N,N-methylene bisacrylamide (MBA) were purchased from Sigma Aldrich and used as received. Deionized water was employed as synthesis medium and solvent. Toluene for cleaning cover slides and ethanol were bought from Sigma Aldrich (anhydrous, 99.8%). A Sylgard 184 elastomer kit, made up of Sylgard 184 monomer and Sylgard 184 base, was obtained from Dow Corning (Midland, MI, USA).
N vinylcaprolactam vcl
Manufactured by Merck Group
Sourced in United States
N-Vinylcaprolactam (VCL) is a heterocyclic organic compound that is commonly used as a monomer in the production of polymers. It has a molecular formula of C₈H₁₃NO and is a colorless, viscous liquid at room temperature.
Automatically generated - may contain errors
Lab products found in correlation
Diethyl ether, by Thermo Fisher Scientific (2 mentions)
Potassium ethyl xanthate, by Thermo Fisher Scientific (2 mentions)
2 bromopropionyl bromide, by Thermo Fisher Scientific (2 mentions)
Acetoacetoxyethyl methacrylate, by Merck Group (1 mentions)
Rhodamine b, by Merck Group (1 mentions)
N n methylenebis acrylamide mba, by Merck Group (1 mentions)
Sylgard 184 elastomer kit, by Dow (1 mentions)
Sylgard 184 monomer, by Dow (1 mentions)
Sylgard 184 base, by Dow (1 mentions)
Zellutrans, by Carl Roth (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Tetrahydrofuran, by Thermo Fisher Scientific (1 mentions)
Triflic acid, by Merck Group (1 mentions)
Dichloromethane, by Thermo Fisher Scientific (1 mentions)
Hydrochloric acid (hcl), by Thermo Fisher Scientific (1 mentions)
Hexane, by Thermo Fisher Scientific (1 mentions)
Sodium bicarbonate, by Thermo Fisher Scientific (1 mentions)
Sodium phosphate dibasic, by Thermo Fisher Scientific (1 mentions)
Potassium carbonate, by Thermo Fisher Scientific (1 mentions)
Chloroform, by Thermo Fisher Scientific (1 mentions)
6 protocols using n vinylcaprolactam vcl
1
Synthesis of Fluorescent Polymer Hydrogels
2
Synthesis and Purification of OFP Crosslinker
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AMPA (97%, Sigma‐Aldrich), BIS (99%, Sigma‐Aldrich), +C (≥98%, Sigma‐Aldrich), CTAB (≥97%, Merck Millipore), DMSO (99.7% Sigma‐Aldrich), and dialysis membranes (Zellu Trans molecular weight cut‐off 12–14 kDa, Carl Roth) were used as received. N‐vinylcaprolactam (VCL, 98%, Sigma‐Aldrich) was purified by vacuum distillation before use. The synthesis of the OFP crosslinker was previously described in refs. [49 , 55 (link), 56 ].
3
Synthesis of PDMS-based Macro-CTA
4
Synthesis and Characterization of PDMS-g-PVCA Copolymers
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2,2′-Azobis(2-methylpropionitrile) (AIBN) (Sigma-Aldrich, Saint Louis, MO, USA) was recrystallized from methanol before use. N-Vinylcaprolactam (VCL) (Sigma-Aldrich) and tetrahydrofuran (THF; Fisher) were distilled prior to use. Potassium ethyl xanthate, 2-bromopropionyl bromide, diethyl ether, hexane, dichloromethane, calcium sulfate anhydrous, sodium bicarbonate, monobasic and dibasic sodium phosphate, and dialysis tubing (MWCO 3 kDa and 20 kDa) were from Fisher Scientific (Suwanee, GA, USA) and were used as received. Poly(dimetylsiloxane) bis(hydroxyethyloxypropyl) (PDMS65, Mn = 5600 Da), 2-methyl-2-oxazoline (MOXA), trifluoromethanesulfonic anhydride (Tf2O), potassium hydroxide, calcium chloride, diethyl ether, and methanol were purchased from Sigma-Aldrich. Potassium carbonate, sodium bicarbonate, sodium chloride, chloroform, hydrochloric acid, and glass fiber filters G4 were purchased from Fisher Scientific. Diethoxydimethylsilane, 1,3-bis(4-hydroxybutyl)tetramethyldisilane were from Silar Laboratories (Riegelwood, NC, USA). Doxorubicin hydrochloride (DOX) was purchased from LC Laboratories. Deionized (DI) water with an 18.2 MΩ cm resistivity was used for the preparation of aqueous solutions.
5
Polymeric Drug Delivery System Synthesis
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Monomers: N-vinyl caprolactam (VCL; Sigma Aldrich, 98%), and Poly(ethylene glycol) diacrylate (PEGDA; Sigma Aldrich, Mn 250 g/mol). Initiator: ammonium persulfate (APS; FMC Corporation,>99%). Emulsifier: sodium dodecyl sulfate (SDS; STEOL®CS-230 Stepan). Buffer: sodium hydrogen carbonate (Sigma-Aldrich, ≥99.7%) used as provided. Colchicine (Sigma Aldrich ≥ 95%), potassium dihydrogen phosphate (Fisher Scientific, 99.6%), and methanol (LiChrosolv®, HPLC grade) were also used as provided. All aqueous solutions were prepared with double deionized water (DDI) produced by aDirect-Q®3 UV Water Purification System.
6
Synthesis and Characterization of VCL-Based Hydrogels
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N-Vinylcaprolactam (VCL, 98%; Sigma-Aldrich) was purified by distillation under vacuum. 2-Methoxyethyl acrylate (MEA, 98%; Sigma-Aldrich) was passed through a basic aluminum oxide column before use to remove the inhibitor. The initiator 2,2 0 -azobis(2-methylpropyonamidine)dihydrochloride (AMPA, 97%; Sigma-Aldrich), the crosslinker N,N 0 -methylenebisacrylamide (BIS, 99%; Sigma-Aldrich), chloroform (99%; VWR), deuterated water (D 2 O, 99.9%; Deutero) and the model drug Cyanine3 (Cy3, Lumiprobe) were used as received.
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