Signa mri system

Manufactured by GE Healthcare

Sourced in United States

The Signa MRI system is a magnetic resonance imaging (MRI) scanner developed by GE Healthcare. It is designed to capture high-quality images of the human body for medical diagnosis and research purposes. The system utilizes strong magnetic fields and radio waves to generate detailed images of internal structures and organs.

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Signa pet mr, by GE Healthcare (1 mentions)

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Signa System (36 citations) Signa HDx 1.5T MRI system (5 citations) Signa HDxt 3.0 T MRI system (4 citations) Signa 1.5 Tesla LX MRI system (2 citations) Signa HDx MRI system (2 citations) Signa LX Echospeed MRI System (2 citations) HDxt Signa/MRI system (2 citations) 3 T Signa HDx MRI system (2 citations) SIGNA HDx 3T MRI system (2 citations) 3T Signa MRI system (2 citations)

9 protocols using signa mri system

DTI Imaging with GE Signa 3T MRI

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The MRI scan of each participant was performed using a 3.0-Tesla whole-body GE Signa MRI system (General Electric Healthcare, Milwaukee, WI, USA) equipped with an eight-channel head coil. DTI was conducted along the anterior-posterior commissure line (AC-PC line) in the axial plane using a single-shot spin-echo echoplanar imaging (EPI) sequence. The DTI gradient encoding schemes included 13 noncollinear directions with a b value of 1000 s/mm² and a nondiffusion-weighted image volume (b value 0 s/mm²).

Chen H.L., Yamada K., Sakai K., Lu C.H., Chen M.H, & Lin W.C. (2020). Alteration of brain temperature and systemic inflammation in Parkinson’s disease. Neurological Sciences, 41(5), 1267-1276.

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Multimodal MRI Neuroimaging Protocol

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Imaging data were acquired on a 3.0T GE Signa MRI system (GE Medical
Systems). All functional data were collected in 33, 3-mm thick oblique axial
slices using an EPI sequence (TR = 2000 ms, TE = 30.5 ms, flip angle = 73;
64×64 matrix, 3.75×3.75 mm in-plane resolution, bottom-up
interleaved acquisition, 0.6 mm gap). T2-weighted structural images were
acquired in the same prescription as the functional images for the memory (TR =
3200 ms, TE = 68 ms, 512×512 matrix, 0.46×0.46 mm in-plane
resolution) and visual localizer (TR = 3200 ms, TE = 68 ms, 256×256
matrix, 0.94×0.94 mm in-plane resolution) tasks. Diffusion-weighted data
were acquired to characterize white matter structure (TR = 12000 ms, TE = 87.1
ms, 25 diffusion directions, maximum b-value = 1000, 128×128 matrix,
0.94×0.94 in-plane resolution, 41 straight axial slices, 3-mm thickness,
no gap). A T1-weighted 3D SPGR structural volume (256 × 256 ×
172 matrix, 1×1 × 1.3 mm voxels) was also collected to
facilitate image coregistration and for automated parcellation using Freesurfer
(http://surfer.nmr.mgh.harvard.edu/) (Desikan et al., 2006 (link)).

Schlichting M.L, & Preston A.R. (2015). Hippocampal-medial prefrontal circuit supports memory updating during learning and post-encoding rest. Neurobiology of learning and memory, 134(Pt A), 91-106.

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Multimodal Neuroimaging Protocol for MRI

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The 3.0 tesla whole-body GE Signa MRI system (General Electric Healthcare, Milwaukee, WI, USA) with an eight-channel head coil was used for MRI scanning. Along the anterior-posterior commissural line (AC-PC line) in the axial plane, DTI was conducted using a single shot echo-planar imaging (EPI) sequence (repetition time/echo time [TR/TE] = 15,800/77 ms, voxel size = 1 × 1 × 2.5 mm³, field of view [FOV] = 25.6 cm, matrix size = 256 × 256, number of excitations [NEX] = 3, and 55 slices without gaping). The gradient encoding schemes are 13 noncollinear directions (b-value of 1000 s/mm²) and a nondiffusion-weighted image volume (b-value of 0 s/mm²) in diffusion images.
T1-weighted images are scanned along the AC-PC line by a three-dimensional fluid-attenuated inversion-recovery fast spoiled gradient recalled echo sequence (3D IR-FSPGR, TR/TE/inversion time = 9.5/3.9/450 ms, flip angle = 20°, voxel size = 0.47 × 0.47 × 1.3 mm³, FOV = 25.6 cm, matrix size = 512 × 512, and 110 slices without gaping). Axial T2-weighted images were scanned by a fast spin-echo sequence (TR/TE = 4,200/102 ms, FOV = 24 cm, matrix size = 320 × 256, NEX = 2, echo train length = 18, and slice thickness = 5 mm). The T1- and T2-weighted images were used to check for any intracranial abnormality. This protocol required twenty minutes for each participant.

Chen M.H., Chen P.C., Lu C.H., Chen H.L., Chao Y.P., Li S.H., Chen Y.W, & Lin W.C. (2017). Plasma DNA Mediate Autonomic Dysfunctions and White Matter Injuries in Patients with Parkinson's Disease. Oxidative Medicine and Cellular Longevity, 2017, 7371403.

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Resting-State fMRI Acquisition Protocol

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The rs-MRI functional images were acquired by adopting a 3.0 T GE SIGNA MRI system at the Image Institute of The First Affiliated Hospital of China Medical University, Shenyang, China. The following are the parameters that were obtained using a gradient echo-planar imaging (EPI) sequence: repetition time (TR) = 2,000 ms, echo time (TE) = 40 ms, field of view (FOV) = 240 × 240 mm², flip angle (FA) = 90°, image matrix size = 64 × 64, slices = 35, slice thickness = 3 mm, spacing between slices = 3 mm. Participants were required to wear earplugs and use foam pads to reduce scanner noise and head motion, and their head was fixedly positioned during scan time. The resting state meant that participants were not doing any cognitive tasks during the scan time and they were asked to keep relaxed and awake with their eyes closed while simultaneously keeping their minds blank. After completing scanning, we obtained a total of 200 volumes of images.

Deng Z., Jiang X., Liu W., Zhao W., Jia L., Sun Q., Xie Y., Zhou Y., Sun T., Wu F., Kong L, & Tang Y. (2022). The aberrant dynamic amplitude of low-frequency fluctuations in melancholic major depressive disorder with insomnia. Frontiers in Psychiatry, 13, 958994.

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3T MRI Structural Brain Imaging

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The images were acquired using a 3T whole body GE Signa MRI system (GE Healthcare). To diminish motion artifact, each subject’s head was immobilized by foam pillows inside the coil. The T1-weighted structured images were acquired using a 3D-FSPGR sequence. The sequence parameters are as follows: repetition time (TR) = 9.492 ms, echo time (TE) = 3.888 ms, flip angle = 20°, matrix size = 512 × 512, field of view (FOV) = 24 × 24 cm, in-plane spatial resolution: 0.47 × 0.47 mm, and slice thickness: 1.3 mm).

Chen Y.S., Chen H.L., Lu C.H., Lee C.Y., Chou K.H., Chen M.H., Yu C.C., Lai Y.R., Chiang P.L, & Lin W.C. (2021). The corticolimbic structural covariance network as an early predictive biosignature for cognitive impairment in Parkinson's disease. Scientific Reports, 11, 862.

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Multimodal Brain Imaging Protocol

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All anatomical and functional data were acquired using a 3.0T Signa MRI system (GE Medical Systems). Four of the participants were scanned at a separate scanner (identical field strength and make) than the others, with slightly different acquisition parameters. For these four participants, the first anatomical series was collected using a T2-weighted flow-compensated spin-echo pulse sequence. The anatomical images were acquired with identical prescription to the functional images (TR = 4.5 s; TE = 80 ms; 30 contiguous 4-mm-thick slices parallel to the AC-PC plane). The second anatomical series was a T1-weighted high-resolution acquisition of the entire brain (TR = 8.368 ms; TE = 1.784 ms; flip angle = 15; FOV = 22 cm; 256 x 256 voxels; 124 contiguous 1.5-mm-thick slices). Functional images were collected using a T2*-weighted two-dimensional gradient echo spiral-in/out pulse sequence (TR = 2s; TE = 30 ms; 1 interleave; flip angle = 75; FOV = 22 cm; 64 x 64 voxels). For the remaining 22 participants, there was a different set of parameters for the T2-weighted anatomical (TR = 3 s; TE = 72 ms; 30 contiguous 4-mm-thick slices parallel to the AC-PC plane) and the T2*-weighted functional images (TR = 2s; TE = 30 ms; 1 interleave; flip angle = 75; FOV = 21 cm; 64 x 64 voxels).

Hutchinson J.B., Uncapher M.R, & Wagner A.D. (2014). Increased Functional Connectivity between Dorsal Posterior Parietal and Ventral Occipitotemporal Cortex during Uncertain Memory Decisions. Neurobiology of learning and memory, 117, 71-83.

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fMRI Exploration of Transcutaneous Vagus Nerve Stimulation

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There were two fMRI scans involved in this exploratory study: a baseline resting state fMRI scan and an fMRI scan during continuous real or sham tVNS stimulation. The acquisition of fMRI brain imaging data was conducted on a 1.5 Tesla GE Signa MRI system (GE Healthcare, Buckinghamshire, United Kingdom) equipped with a standard two-channel birdcage head coil. T1-weighted high-resolution structural images were acquired with the three-dimensional fast spoiled gradient-echo sequence (matrix 192×256, field of view 200 mm, flip angle 15º, slice thickness 1.4 mm). Functional images encompassing the whole brain were acquired with the gradient echo echo-planar imaging sequence (echo time 30 milliseconds, repetition time 2500 milliseconds, matrix 64×64, field of view 240 mm, flip angle 90º, slice thickness 3.0 mm, gap 0.5 mm, 41 slices, parallel to the anterior commissure-posterior commissure line). Image collection was preceded by four dummy scans to allow for equilibration of the MRI signal. The subjects were required to keep still during the two 6-minute fMRI scans.

Wang Z., Fang J., Liu J., Rong P., Jorgenson K., Park J., Lang C., Hong Y., Zhu B, & Kong J. (2017). Frequency-dependent functional connectivity of the nucleus accumbens during continuous transcutaneous vagus nerve stimulation in major depressive disorder. Journal of psychiatric research, 102, 123-131.

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High-Resolution MRI Acquisition of Anatomical Brain

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Images of 46 participants were acquired using a 3.0 Tesla General Electric SIGNA MRI system (Signa PET/MR, GE Healthcare, Milwaukee, WI, USA) equipped with an 8-channel head coil. A T1-weighted anatomical scan was obtained using a fast spoiled-gradient recalled imaging sequence with the following parameters; Repetition Time (TR) = 8.488 ms, Echo Time (TE) = 3.248 ms, Flip angle (FA) = 11°, Field of view (FOV) = 256 mm, matrix size = 256 × 256, volume dimensions = 1.0 × 1.0 × 1.0 mm³, slice thickness = 1.0 mm, and a total of 172 slices.

Yao A., Nishitani S., Yamada Y., Oshima H., Sugihara Y., Makita K., Takiguchi S., Kawata N.Y., Fujisawa T.X., Okazawa H., Inatani M, & Tomoda A. (2024). Subclinical structural atypicality of retinal thickness and its association with gray matter volume in the visual cortex of maltreated children. Scientific Reports, 14, 11465.

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High-Resolution Structural Brain Imaging

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After informed consent, each subject underwent one MR Scanning session to obtain high resolution structural data. All MR scanning was performed on a 3.0 Tesla GE Signa MRI System (General Electric, Waukesha, WI) at The University of Chicago Brain Research Imaging Center (BRIC). Prior to each imaging session, subjects were confirmed to be negative for recent drug use and for females, pregnancy, by urinalysis. Once positioned, head movement was minimized through: a) instructions to participants; b) packing the head inside the head coil with foam padding and pillows that limit head motion. A high-resolution T1-weighted 3D MP-RAGE scan was acquired to provide precise anatomical information. The parameters for MP-RAGE were: TE = 3.2ms, TR = 8ms, preparation time = 725 ms, flip angle 6°, field of view 24 cm × 24 cm, 124 sagittal slices, 1.5 mm slice thickness, 192 × 256 image matrix reconstructed to 256 × 256.

Coccaro E.F., Lee R., McCloskey M., Csernansky J.G, & Wang L. (2015). MORPHOMETRIC ANALYSIS OF AMYGDLA AND HIPPOCAMPUS SHAPE IN IMPULSIVELY AGGRESSIVE AND HEALTHY CONTROL SUBJECTS. Journal of psychiatric research, 69, 80-86.

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