Clinpro

Manufactured by 3M

Sourced in United States

Clinpro is a dental device manufactured by 3M for use in dental clinics and laboratories. It is designed to aid in the cleaning and polishing of tooth surfaces.

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Lab products found in correlation

Adper single bond 2, by 3M (1 mentions) Adper easy one, by 3M (1 mentions) Filtek z350 xt, by 3M (1 mentions) Phosphoric acid, by 3M (1 mentions) Elipar, by 3M (1 mentions) Beautisealant, by Shofu (1 mentions) Chitosan, by Merck Group (1 mentions) Sonicflex 2003l, by KaVo (1 mentions)

10 protocols using clinpro

Comparative Evaluation of Adhesive Sealants

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In control arm (TE adhesive) the selected tooth received prophylaxis with brushes for 10-15 seconds using a slow speed hand piece. Isolation was achieved with cotton rolls. The occlusal fissures were treated with 37% phosphoric acid (Total Etch Ivoclar Vivadent, Switzerland) for 15 seconds followed by rinsing for 30 seconds and then drying with air syringe. Adper Single Bond 2 (3M ESPE, US) was applied to occlusal fissure using microbrushes. After application the adhesive was light cured (ColtoLux by Coltene Whaledent, Switzerland) for 10 seconds. After curing of the adhesive, opaque fissure sealant material (Clinpro by 3M ESPE, US) was applied and light cured for 20 seconds.
In the intervention arm (SE adhesive) similar steps for prophylaxis and isolation was done as in control arm. SE adhesive (Adper Easy One, 3M ESPE, US) was applied to occlusal fissures with microbrushes and was rubbed on fissure surface with microbrush for 20 seconds. This was followed by air drying for 10-15 seconds followed by light curing for 10 seconds. Sealant was applied (Clinpro 3M ESPE, US) in a similar manner as for control group.

Aman N., Khan F.R., Salim A, & Farid H. (2015). A randomized control clinical trial of fissure sealant retention: Self etch adhesive versus total etch adhesive. Journal of Conservative Dentistry : JCD, 18(1), 20-24.

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Evaluation of Pit and Fissure Sealants

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A total of 54 freshly extracted maxillary and mandibular premolar teeth were used in this study (Fig. 1). The teeth were first disinfected with hydrogen peroxide (VL Products, Maharashtra, India), cleaned off from gross debris with pumice slurry using brushes with a slow-speed handpiece, then the teeth were rinsed with air-water spray, and a sharp explorer tip was passed through all the pits and fissures to remove the remaining pumice. After the following tooth preparation, the teeth were then rinsed and placed in an artificial saliva solution (Wet mouth solution, ICPA Health Products Ltd.).^{7 (link)} The specimens were then randomly divided into three groups of 18 teeth each, and these were the following pit and fissure sealants used group I—Clinpro (3M ESPE), group II—GC Fuji Triage Capsule, and group III—Filtek Z350 XT (3M ESPE). These pit and fissure sealants were then applied according to the manufacturer's instructions (Fig. 2).

Prabahar T., Chowdhary N., Konkappa K.N., Vundela R.R, & Balamurugan S. (2022). Evaluation of Microleakage of Different Types of Pit and Fissure Sealants: An In Vitro Comparative Study. International Journal of Clinical Pediatric Dentistry, 15(5), 535-540.

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Nanohydroxyapatite and SHMP Effects on Fissure Sealant

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After demineralization, the enamel was pretreated as follows and fissure sealant was applied:
Group 1 (control): The enamel was etched with phosphoric acid 35% (3 M, ESPE, St. Paul, MN, USA) for 20 s, rinsed and dried under a weak air stream. Then an unfilled fissure sealant (FS) (Clinpro, 3 M ESPE, St. Paul, Minn, USA) was applied and cured with a halogen light curing unit (Coltolux, Coltene, Whaledent, Altstaetten, Switzerland) at a power density of 550 mW/cm² for 40 s.
Group 2 (nano-HA 0.15%): After the enamel was etched as described above for group 1, each sample was immersed in 5 mL of a solution that contained 0.15% nano-HA in a closed glass vial with continuous slow speed rotation (4 rmp) for 5 min to ensure that the nanoparticles remained in suspension and to avoid precipitation [24 (link)]. Then each tooth was dried under an air stream and the sealant was applied.
Group 3 (nano-HA 0.03%): The procedures were similar to group 2, except that the solution contained nano-HA at 0.03% concentration.
Group 4 (nano-HA 0.15% + SHMP 0.05%): The solution powder contained nano-HA 0.15% and SHMP 0.05%, which were mixed together before the solvent was added. The other procedures were similar to groups 2 and 3.
Group 5 (nano-HA 0.03% + SHMP 0.01%): The procedures were similar to group 4, except that the solution contained nano-HA at 0.03% and SHMP at 0.01%.

Memarpour M., Shafiei F., Rafiee A., Soltani M, & Dashti M.H. (2019). Effect of hydroxyapatite nanoparticles on enamel remineralization and estimation of fissure sealant bond strength to remineralized tooth surfaces: an in vitro study. BMC Oral Health, 19, 92.

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Fluoride-Releasing Sealants Evaluation

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The materials used in this study were a Giomer and three fluoride-releasing sealants divided into 4 groups with eight samples of each sealant: G1 — BeautiSealant (Shofu, Japan); G2 — Clinpro (3M ESPE, USA); G3 — Helioseal F (HF) (Ivoclar Vivadent, Liechtenstein); and G4 — UltraSeal XT (US) plus (Ultradent Products, USA).
The materials were handled according to the manufacturers’ instructions and 32 samples were prepared. The samples consisted of eight blocks of each sealant with 5 mm width and 1 mm thickness; the samples were placed in cavities with similar measures in a Teflon matrix.[7 ]
All samples were polymerized using a LED device (Elipar, 3M ESPE) for 40 s, verifying with a radiometer that the intensity of light emitted has a minimum value of 400 mW/cm².
The polymerized samples were removed from the matrix and were then stored in plastic bottles with 5 ml of deionized water. The samples were conserved at 37°C for 60 days and measured on days 1, 2, 4, 8, 28, and 60, which is similar to the time intervals used in previous studies.[8 9 (link)]

Salmerón-Valdés E.N., Scougall-Vilchis R.J., Alanis-Tavira J, & Morales-Luckie R.A. (2016). Comparative study of fluoride released and recharged from conventional pit and fissure sealants versus surface prereacted glass ionomer technology. Journal of Conservative Dentistry : JCD, 19(1), 41-45.

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Evaluation of Remineralizing Agents

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Three commercially available remineralizing agents were used for this study:

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Fluoride varnish 25 ml (5% NaF) – BELAK-F (VladMiVa, Russia).

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TCP paste –Clinpro™ (3 M ESPE, USA).

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Nano-Hydroxyapatite gel – CTx4 Gel 1100 (CariFree, Canada).

Alhamed M., Almalki F., Alselami A., Alotaibi T, & Elkwatehy W. (2019). Effect of different remineralizing agents on the initial carious lesions – A comparative study. The Saudi Dental Journal, 32(8), 390-395.

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Chitosan-Enhanced Resin Sealant Evaluation

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This experimental study was conducted on six groups of the resin sealant containing 0, 1, 2, 3, 4, and 5 wt% chitosan. For higher precision, three specimens were prepared from each group (n = 18). chitosan-containing sealant was prepared in a dark room under red light to avoid early polymerization of resin. For the preparation of sealants with different concentrations of chitosan, first a sterile hourglass was placed on a laboratory scale and adjusted to zero. Then, the sealant tube (Clinpro; 3M ESPE, Saint Paul, MN, USA) was squeezed out into the hourglass and after weight determination (about 1.5 g), the desired amount of chitosan (Sigma Aldrich Chemical Co., Saint Louis, MO, USA) was added to the sealant in hourglass to obtain 1, 2, 3, 4, and 5 wt% concentrations. The mixture was stirred manually with a plastic spatula for 15 min to evenly spread the chitosan particles in the sealant. One chitosan-free sealant group was considered as the control group.

Rajabnia R., Ghasempour M., Gharekhani S., Gholamhoseinnia S, & Soroorhomayoon S. (2016). Anti-Streptococcus mutans property of a chitosan: Containing resin sealant. Journal of International Society of Preventive & Community Dentistry, 6(1), 49-53.

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Randomized Comparison of Pit and Fissure Sealants

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Randomization was carried out by an operator who was not involved in any other phases of the clinical trial. The unit of randomization was the individual tooth. A coin was tossed to determine which tooth the conventional acid etch pit and fissure sealant (Group 1: 3M™ ClinPro™, India, 3M ID 70201412429)
¹¹ would be applied to. If the coin landed as Heads, the sealant was placed on the right mandibular first permanent molar. Subsequently, the self-etch pit and fissure sealant (Group 2: Preventseal (Itena
^®, France, PVSEAL-1.2)
¹² was applied on the left mandibular molar. Similarly, if the coin landed as Tails, the conventional sealant was placed on the left mandibular first permanent molar and the self-etch pit and fissure sealant was applied on the right mandibular molar.
The group allocation was revealed to the principal investigator who performed the intervention just before the sealant placement procedure began by the operator who had carried out the randomization.

Gupta D., Rao A., Shenoy R, & Suprabha B.S. (2022). Comparison of clinical effectiveness of conventional and self-etch sealant: a split mouth randomized controlled trial. F1000Research, 11, 261.

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Evaluating Resin Sealant Retention

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Unfilled resin sealant (Clinpro, 3M ESPE, USA) was applied onto the etched pits and fissures of the occlusal surface using a micro applicator tip and light-cured for 20 seconds with LED curing light of wavelength 420–480 nm according to manufacturer instructions.
Occlusion evaluation was done for both the groups using articulating paper and the premature occlusal contacts if present were relieved using finishing bur. Evaluation of sealant retention was done at 6, 12, and 18-month intervals using Tonn and Ryge criteria⁵under a dental operating microscope at 0.6x magnification.

Bhuvaneswari P., Vinay C., Uloopi K., RojaRamya K.S., Chandrasekhar R, & Chaitanya P. (2022). Clinical Evaluation of the Retention of Self-adhering Flowable Composite as Fissure Sealant in 6–9-year-old Children: A Randomized Controlled Trial. International Journal of Clinical Pediatric Dentistry, 15(3), 322-326.

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Bioactive Nanofillers in Pit and Fissure Sealants

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In the present pilot laboratory study, four PFS were prepared using monomers with a mixture of 35.5 wt % BisGMA, 35.5 wt % triethylene glycol dimethacrylate (TEGDMA) and 28 wt % hydroxyethyl methacrylate (HEMA). Bioactive nanofillers (nHAP and n-ACP) were added in various concentrations: (1) Unfilled 0% filler (2) 30% nHAP filler; (3) 10% nHAP + 20% silica filler; (4) 10% nHAP + 20% nACP filler. The total filler mass fraction was 30%. Commercially available ACP containing PFS (Aegis-Opaque White, Bosworth Co. Ltd.) which is 38% filled with ACP was used as another test material. Two commercial materials were used as comparative controls. Unfilled PFS served as a negative control (Clinpro, 3M ESPE). Fluoride-releasing PFS (Delton FS plus, Dentsply) which contains barium alumino fluoroboro silicate glass as filler served as positive control. This study comprised two control groups and five experimental groups. The commercially available base monomers, diluent monomers, and the polymerization initiator systems used to fabricate experimental resins are listed in Table 1. The various test materials used in the present study are shown inTable 2.

Utneja S., Talwar S., Nawal R.R., Sapra S., Mittal M., Rajain A, & Verma M. (2018). Evaluation of remineralization potential and mechanical properties of pit and fissure sealants fortified with nano-hydroxyapatite and nano-amorphous calcium phosphate fillers: An in vitro study. Journal of Conservative Dentistry : JCD, 21(6), 681-690.

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Mechanical Approach to Periodontal Health

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Full mouth supragingival cleaning was performed after assessment of secondary parameters, but 24 hours prior to the assessment of the PFR scores. This was done with sonic scalers with micro tips (Sonicflex 2003L, KAVO, Bieberach, Germany) and subsequent air polishing with glycine powder (ClinPro, EMS, 3M Espe, Seefeld, Germany) and an air flow device (EMS S1, EMS Electro Medical Systems, Nyon, Switzerland) at visits 2a, 3a, and 4a. Subsequently after “a” visits, patients were instructed to refrain from any oral hygiene measures for the following 24 hours. After each PFR assessment, patients were instructed to resume their regular oral hygiene. Dentifrices for test and control groups were dispensed after visit 2b.
Additionally, periodontal therapy performed at visit 3a comprised full mouth supragingival and, where indicated, subgingival debridement (sites with PPD ≤ 4mm). Subgingival debridement was performed under local anesthesia using sonic scalers followed by air polishing with glycine powder. The period of time between visits was chosen to evaluate the effects of the different mechanical approaches in conjunction with the different toothpastes (visit 2a to visit 3a: 4 weeks after the supragingival debridement and oral hygiene, and visit 3a to 4a: 8 weeks after the supra- and subgingival approach).

Harks I., Jockel-Schneider Y., Schlagenhauf U., May T.W., Gravemeier M., Prior K., Petersilka G, & Ehmke B. (2016). Impact of the Daily Use of a Microcrystal Hydroxyapatite Dentifrice on De Novo Plaque Formation and Clinical/Microbiological Parameters of Periodontal Health. A Randomized Trial. PLoS ONE, 11(7), e0160142.

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