Prazosin hydrochloride

Manufactured by Fujifilm

Sourced in Japan

Prazosin hydrochloride is a synthetic compound used in various laboratory applications. It is a crystalline solid that is soluble in water and organic solvents. Prazosin hydrochloride is commonly used as a research tool in scientific experiments and studies, but its specific core function and intended use should not be extrapolated upon in this factual description.

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Lab products found in correlation

Dimethyl sulfoxide (dmso), by Fujifilm (1 mentions) Phenylephrine, by Fujifilm (1 mentions) Isoproterenol, by Bio-Techne (1 mentions) Scopolamine n butyl bromide, by Merck Group (1 mentions) Butoxamine hydrochloride, by Merck Group (1 mentions)

4 protocols using prazosin hydrochloride

Exploring Cardiovascular Effects of Prazosin and Propranolol

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Prazosin hydrochloride (1 mg/kg) (Wako Pure Chemical Industries Ltd, Osaka, Japan), and propranolol hydrochloride (2 mg/kg) (TOKYO KASEI, Tokyo, Japan) were used in this experiment. Saline was used for the vehicle treatment.

Sasaki H., Hattori Y., Ikeda Y., Kamagata M., Iwami S., Yasuda S., Tahara Y, & Shibata S. (2016). Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice. Scientific Reports, 6, 27607.

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Naftopidil and Prazosin Dissolution Protocol

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Naftopidil (PubChem CID: 4418) (Asahi Kasei Pharma Co., Tokyo, Japan) was dissolved in 1% dimethyl sulfoxide (DMSO) (PubChem CID: 679) (Wako, Osaka, Japan) in Krebs solution. The other drugs were dissolved in Krebs solution and applied by perfusion via a 3-way stopcock without changes in the perfusion rate or temperature. The other drug used in this study was prazosin hydrochloride (PubChem CID: 68546) (Wako).

Uta D., Hattori T, & Yoshimura M. (2018). Effects of High Concentrations of Naftopidil on Dorsal Root-Evoked Excitatory Synaptic Transmissions in Substantia Gelatinosa Neurons In Vitro. International Neurourology Journal, 22(4), 252-259.

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Adrenoceptor Agonists and Antagonists

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We used prazosin hydrochloride (1 mg/kg) (Wako Pure Chemical Industries Ltd., Osaka, Japan) and propranolol hydrochloride (1 or 10 mg/kg) (TOKYO KASEI, Tokyo, Japan) as adrenoceptor antagonists. Phenylephrine (5 mg/kg) (Wako Pure Chemical Industries Ltd, Osaka, Japan) and isoproterenol (5 mg/kg) (Tocris Bioscience, Bristol, United Kingdom) were used as α receptor and β receptor agonists, respectively. Pilocarpine was mixed with 1X PBS and used as a control treatment.

Wada M., Orihara K., Kamagata M., Hama K., Sasaki H., Haraguchi A., Miyakawa H., Nakao A, & Shibata S. (2017). Circadian clock-dependent increase in salivary IgA secretion modulated by sympathetic receptor activation in mice. Scientific Reports, 7, 8802.

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Pharmacological Agents in Intraperitoneal Administration

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All drugs were dissolved in saline and injected intraperitoneally. Butoxamine hydrochloride (B1385; Sigma-Aldrich, St Louis, MO, USA), carazolol (C2578; Tokyo Chemical Industry, Tokyo, Japan), prazosin hydrochloride (162-14681; Wako, Osaka, Japan), and (−)-scopolamine N-butyl bromide (S7882; Sigma-Aldrich, St Louis, MO, USA) were used in this study.

Yamashita S., Dozono N., Tobori S., Nagayasu K., Kaneko S., Shirakawa H, & Ueda H. (2023). Peripheral Beta-2 Adrenergic Receptors Mediate the Sympathetic Efferent Activation from Central Nervous System to Splenocytes in a Mouse Model of Fibromyalgia. International Journal of Molecular Sciences, 24(4), 3465.

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