Biochemistry panel plus

Blood was collected at scheduled time points (Days −7, 0, 3, 5, 7, 9, 11, 13, and 14, relative to exposure). Coagulation times were determined on whole blood collected with no additives, using an IDEXX Coag Dx Analyzer (IDEXX Laboratories, Westbrook, ME, USA). These blood samples were processed to obtain the serum. Serum was analyzed to measure C-reactive protein (CRP) levels using a Piccolo BioChemistry Panel Plus on a Vet Scan analyzer (Abaxis, Inc., Union City, CA, USA). Whole blood was also collected into tubes containing ethylenediaminetetraacetic acid (EDTA) for complete blood counts (CBC) using a Procyte Dx Hematology Analyzer (IDEXX laboratories, Westbrook, ME, USA) and for clinical chemistry using the mammalian liver enzyme profile rotor on a Vet Scan analyzer (Abaxis, Inc., Union City, CA, USA).

Blood was collected from sedated animals at scheduled time points, as described in Section 2.2 and Figure 1a. Coagulation analysis, complete blood counts (CBC), and clinical chemistry analyses were performed, as previously described [38 (link),39 (link),40 (link),41 (link)]. Serum was also analyzed for C-Reactive Protein (CRP) levels using a Piccolo BioChemistry Panel Plus on a Vet Scan analyzer (Abaxis, Inc., Union City, CA, USA). Hematology and serum chemistry parameters shown below (Table 1) are provided (Figure 1c–h). The coagulation assessments performed were activated partial thromboplastin time (aPTT) and prothrombin time (PT) (Figure 1i,j).