Cobas e 601 automated analyzer

Manufactured by Roche

Sourced in Japan

The Roche cobas e 601 Automated Analyzer is a compact, fully automated immunoassay analyzer. It is designed to perform a wide range of immunoassay tests, including tests for hormones, infectious diseases, and other clinical parameters. The cobas e 601 features advanced technologies to ensure reliable and accurate results.

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Lab products found in correlation

Dimension xpand, by Siemens (1 mentions)

Close spelling variants of this product

Cobas 601 analyzer COBAS automated analyzer Cobas e analyzer Cobas 601 Cobas e Cobas analyzer Automated analyzer

3 protocols using cobas e 601 automated analyzer

Measurement of Vitamin D Metabolites and Bone Markers

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Serum levels of 25(OH)D2 and 25(OH)D3 were measured by LC/MS/MS on an AB SCIEX Triple Quad 4500MD™ LC/MS/MS. Serum samples were mixed with ZnS0₄ solution (protein precipitant), 25(OH)D2-IS, and 25(OH)D3-IS (internal standard) on a 96-well plate and rotated at 600 rpm for 10 minutes. After being centrifuged at 4000 rpm for 5 minutes, they were analyzed by using the HPLC/MS/MS system in the atmospheric pressure chemical ionization (APCI) mode and multiple reaction monitor (MRM) mode. The limits of detection were both 0.01 ng/mL for 25(OH)D2 and 25(OH)D3. The intra- and interassay coefficients of variation (CV) were both less than 15% for 25(OH)D2 and 25(OH)D3. Total 25(OH)D levels were calculated as the sum of 25(OH)D2 and 25(OH)D3. Serum levels of iPTH, beta-crosslaps (beta-CTx), procollagen type I N-terminal propeptide (P1NP), and total osteocalcin (OC) were measured with electrochemiluminescence immunoassay on an automatic device (Roche cobas e 601 Automated Analyzer, Roche Diagnostics, Tokyo, Japan). The intra- and interassay CVs were 1.22–2.44% and 1.91–2.61% for iPTH, 1.48–2.72% and 2.06–3.26% for beta-CTx, 1.85–3.06% and 2.41–4.00% for P1NP, and 1.01–2.21% and 1.56–3.56% for OC, respectively.

Bian P., Jin X, & Shou Z. (2021). Effects of Monthly Intramuscular High-Dose Vitamin D2 on Serum 25-Hydroxyvitamin D and Immune Parameters in Very Elderly Chinese Patients with Vitamin D Deficiency. International Journal of Endocrinology, 2021, 1343913.

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Comprehensive Cardiovascular Biomarker Profiling

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Levels of lipid profile parameters (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG)), urea (UREA), creatinine (CREA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), lactate dehydrogenase (LDH), α-amylase (α-AMY), alkaline phosphatase (ALP), total proteins (TP), and albumin (ALB), were measured using spectrophotometry commercial kits (Siemens Healthcare Diagnostics Inc., Newark, NJ, USA) on an automatic analyzer (Dimension Xpand, Siemens, Erlangen, Germany). The serum high-sensitive cardiac troponin T (hs cTnT) levels were measured with a highly sensitive assay using the Roche Cobas e601 automated analyzer (Roche Diagnostics, Mannheim, Germany). Fibrinogen concentration was determined by the modified Clauss assay (Siemens Healthineers Headquarters, Erlangen, Germany) and von Willebrand factor (vWF) activity was determined by particle enhanced assay INNOVANCE^® VWF Ac.

Ilic A., Todorovic D., Mutavdzin S., Boricic N., Bozic Nedeljkovic B., Stankovic S., Simic T., Stevanovic P., Celic V, & Djuric D. (2021). Translocator Protein Modulation by 4′-Chlorodiazepam and NO Synthase Inhibition Affect Cardiac Oxidative Stress, Cardiometabolic and Inflammatory Markers in Isoprenaline-Induced Rat Myocardial Infarction. International Journal of Molecular Sciences, 22(6), 2867.

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Serum Bone Turnover Markers Analysis

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After fasting overnight, venous blood samples were collected from all participants between 07.00 hours and 09.00 hours. Blood samples were placed at ambient temperature for 30 min for coagulation, followed by centrifugation at 2500 g for 10 min to separate serum, and then stored at -70 °C for further analysis. Serum concentrations of β-CTX, P1NP and OC were measured with electrochemiluminescence immunoassay by using an automatic device (Roche cobas e 601 Automated Analyzer; Roche Diagnostics, Tokyo, Japan). The intra-and interassay coefficients of variation were 2.0% and 4.2% for β-CTX, 0.8% and 4.0% for P1NP, and 0.5% and 1.4% for OC, respectively.

Shou Z., Jin X., Bian P., Li X, & Chen J. (2017). Reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly Chinese men. Geriatrics & gerontology international, 17(5).

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