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Eovist primovist

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Eovist/Primovist is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) procedures. It is designed to enhance the visualization of lesions in the liver and biliary tract.

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Lab products found in correlation

Magnetom aera, by Siemens (3 mentions) Magnetom skyra, by Siemens (2 mentions) Magnetom avanto, by Siemens (2 mentions) Ge signa excite, by GE Healthcare (1 mentions) Biograph mmr, by Siemens (1 mentions) Intera, by Philips (1 mentions) Magnetom skyra 3.0t, by Siemens (1 mentions) Multihance, by Bracco (1 mentions) Signa 1.5t, by GE Healthcare (1 mentions)

Close spelling variants of this product

Primovist (164 citations) Eovist (34 citations)

9 protocols using eovist primovist

1

Gadoxetic Acid-Enhanced Liver MRI Protocol

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All MRI examinations were performed on a 1.5 T Magnetom Aera (Siemens Healthcare, Erlangen, Germany) using an eight-channel body phased-array coil. Transverse T1-weighted images (T1WIs) (volume-interpolated breath-hold examination (VIBE) sequence covering the entire liver with 60–80 slices and an adjusted field of view of 255–300 × 340–400 mm) were acquired before and approximately 20 min after manual intravenous bolus administration of 0.1 ml per kg body weight of gadoxetic acid (Gd-EOB-DTPA, gadoxetate disodium; Primovist/Eovist, Bayer HealthCare, Berlin, Germany)23 (link). Imaging parameters were as follows: repetition time (TR) of 4.58 ms, echo time (TE) of 2.25 ms, flip angle (FA) of 9°, slice thickness of 3 mm, and matrix size of 276 × 340.
Elkilany A., Fehrenbach U., Auer T.A., Müller T., Schöning W., Hamm B, & Geisel D. (2021). A radiomics-based model to classify the etiology of liver cirrhosis using gadoxetic acid-enhanced MRI. Scientific Reports, 11, 10778.
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2

Gadoxetate-enhanced MRI of the Liver

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MRI examinations were performed at our institution using 6 different scanners: 1.5T Magnetom Avanto, 1.5T Magnetom Aera, 3.0T Magnetom Skyra, 3.0T Biograph mMR (Siemens Healthcare, Erlangen, Germany), 1.5T Intera (Philips, Best, The Netherlands), and 1.5T GE Signa Excite (GE Medical Systems, Milwaukee, WI, USA). In all examinations, transverse T1-weighted images covering the entire liver with 60–80 slices were acquired before and approximately 20 min after intravenous bolus injection of 0.1 ml/kg body weight of gadoxetic acid (Gd-EOB-DTPA, gadoxetate disodium; Primovist®/Eovist®, Bayer HealthCare, Berlin, Germany). MRCP and T2-weighted sequences were performed before gadoxetic acid administration. Sequence parameters are listed in Supplementary Table 1.
Elkilany A., Geisel D., Müller T., Fischer A, & Denecke T. (2020). Gadoxetic acid-enhanced MRI in primary sclerosing cholangitis: added value in assessing liver function and monitoring disease progression. Abdominal Radiology (New York), 46(3), 979-991.
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3

Dynamic Contrast-Enhanced MRI Protocol for Liver Imaging

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This study used 3.0 T MRI (MAGNETOM Skyra 3.0 T, Siemens, Germany) to examine all subjects. Standard 16-channel phased-array body coil and 32-channel phased-array spinal coil were applied to the coils. T1-weighted images (T1WI) were captured using rapid dynamic enhanced imaging sequences before and after contrast injection. The protocol was as follows: TR/TE, 3.97 ms/1.29 ms; slice thickness, 6 mm; flip angle, 9°; field of view, 380 mm × 320 mm; Matrix: 360 × 100%. Gd-EOB-DTPA (Primovist/Eovist, Bayer Healthcare, Germany) was administered intravenously (0.025 mmol/kg, 1.0 mL/s) and was then flushed with 20 mL of saline. Triple arterial phase, portal venous, transitional, and hepatobiliary phase images (20–35 s, 60 s, 300 s, and 20 min after injection) were acquired with a single breath-hold approach. After scanning, all imaging data were uploaded and evaluated.
Zhang W.Y., Sun H.Y., Zhang W.L, & Feng R. (2023). Effect of type 2 diabetes on liver images of GD-EOB-DTPA-enhanced MRI during the hepatobiliary phase. Scientific Reports, 13, 543.
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4

Gadoxetic Acid-Enhanced Liver MRI

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Our retrospective, single-center study was approved by the ethics committee of the Medical University of Vienna, and the study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki.
The cohort was recruited in a single academic center, the Medical University of Vienna, from consecutive patients in our liver MRI database. All patients provided written informed consent before undergoing gadoxetic acid-enhanced (Primovist/Eovist; Bayer, Berlin, Germany) MRI on a 3.0-T imager between January 2011 and December 2015 (n = 2791). Inclusion and exclusion criteria are in Appendix E1 (online).
Bastati N., Beer L., Mandorfer M., Poetter-Lang S., Tamandl D., Bican Y., Elmer M.C., Einspieler H., Semmler G., Simbrunner B., Weber M., Hodge J.C., Vernuccio F., Sirlin C., Reiberger T, & Ba-Ssalamah A. (2020). Does the Functional Liver Imaging Score Derived from Gadoxetic Acid-enhanced MRI Predict Outcomes in Chronic Liver Disease?. Radiology, 294(1).
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5

Standardized MRI Imaging Protocol for Y-90 Radioembolization

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Every patient received cross-sectional imaging before and after Y-90 radioembolization. According to the standard protocols at our institution, CE MRI was performed with a 1.5-T (Siemens Avanto or Aera) imaging unit. A phased-array torso coil and 0.1 mL per kilogram body weight of intravenous dinatrium gadoxetat (Eovist/Primovist, Bayer Healthcare) were used. The MRI protocol included breath-hold unenhanced and CE T1-weighted 3D fat-suppressed spoiled gradient-echo imaging (section thickness, 2.5 mm; receiver bandwidth, 64 kHz; flip angle, 10°) in the arterial phase (delay of 15 s after bolus tracking), the portal venous phase (delay of 70 s), the delayed phase (delay 3 min), and the hepatobiliary excretion phase (delay of 20 min after administration). Arterial phase was used for volumetric evaluation.
Lüdemann W., Kahn J., Pustelnik D., Hardt J., Böning G., Jonczyk M., Amthauer H., Gebauer B., Hamm B, & Wieners G. (2022). Yttrium-90 radioembolization for unresectable hepatocellular carcinoma: predictive modeling strategies to anticipate tumor response and improve patient selection. European Radiology, 32(7), 4687-4698.
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6

Comparison of Gadoxetic Acid and Gadobenate Dimeglumine Contrast Agents

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At site A, gadobenate dimeglumine (Multihance; Bracco Diagnostics, Princeton, NJ) was administered at a dose of 0.1 mmol per kilogram of body weight at a rate of 2 mL/sec, followed by a 50mL saline flush. Gadoxetic acid (Eovist/ Primovist; Bayer Healthcare Pharmaceuticals, Wayne, NJ) was administered at a dose of 0.05 mmol/kg at a rate of 2 mL/sec, followed by a 50-mL saline flush. A dose of 0.05 mmol/kg gadoxetic acid is used as the standard of care at site A. This is based on previous data (25 (link)–27 (link)) that demonstrated superior contrast agent performance during the arterial phase. It should be noted that the concentration of gadoxetic acid (0.25 M) was half that of gadobenate dimeglumine (0.5 M); therefore, the volume of the two injections was identical (0.2 mL/kg). The choice of gadoxetic acid or gadobenate dimeglumine was based on a standardized protocol at site A in which gadobenate dimeglumine is used primarily in patients with cirrhosis, whereas gadoxetic acid is used for assessment of liver disease in patients without cirrhosis. However, seven patients with cirrhosis were imaged with gadoxetic acid because assessment of biliary disorder was the purpose of the MR imaging examinations (Table 3).
At site B, gadoxetic acid was administered at a dose of 0.025 mmol/kg at a rate of 1 mL/sec, followed by a saline flush of 20 mL.
Motosugi U., Bannas P., Bookwalter C.A., Sano K, & Reeder S.B. (2015). An Investigation of Transient Severe Motion Related to Gadoxetic Acid–enhanced MR Imaging. Radiology, 279(1), 93-102.
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7

Abdominal MRI Protocol for Liver Assessment

Cited 3 times
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All exams were performed using a 1.5T scanner (Magnetom Aera, Siemens Healthineers, Erlangen, Germany), equipped with an 18-channel body array coil. The study protocol consisted of the following sequences: 1) standard abdominal MRI sequences: coronal and axial T2 half-Fourier single-shot turbo spin-echo (HASTE), liver iron and fat quantification with multiecho Dixon (LiverLab), T1 volumetric interpolated breath-hold examination [VIBE] before and after administration of 10 ml of gadoxetate disodium (Eovist/Primovist, Bayer Healthcare Pharmaceuticals, New Jersey, USA) at 2ml/s, T2* mapping (time to echo: 2.3–14.2 msec), and diffusion-weighted imaging, 2) research sequences: T1ρ, pre-contrast T1 mapping, T1-HBP, 4D flow imaging, dynamic contrast-enhanced MRI, and MRE [5 (link), 35 (link)]. The data relevant to T1ρ, 4D flow imaging, dynamic contrast-enhanced MRI, and MRE are not included in the current study and have been or will be reported separately [37 (link), 38 (link)].
Stuart M.R., Chou L.S, & Weimer B.C. (1999). Influence of Carbohydrate Starvation and Arginine on Culturability and Amino Acid Utilization of Lactococcus lactis subsp. lactis. Applied and Environmental Microbiology, 65(2), 665-673.
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8

Multiparametric Liver MRI Protocol

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All MR examinations were performed on a 3 T MR scanner (MAGNETOM Skyra, VE11E version, and Vida, VA20A version, Siemens Healthcare, Erlangen, Germany) using a combination of 18-channel (Skyra) and 30-channel (Vida) flexible anterior body coils and 32-channel spine coil elements for signal acquisition. All patients underwent three T2WI acquisitions before the injection of gadoxetic acid (Eovist/Primovist; Bayer Healthcare, Berlin, Germany). The T2WI comprised the following: (1) a conventional axial T2W SSFSE with fat suppression (SSFSECONV), (2) a multishot T2W turbo spin-echo (TSE) with fat suppression (mTSE), and (3) an axial T2W SSFSECS with fat suppression. For SSFSE acquisition, the percentage of partial Fourier was 75% (6/8), and an additional homodyne filter was applied to synthesize the missing k-space data. In addition, the acquisition time per slice was 0.7–1.0 s in SSFSECONV and 0.5–0.6 s in SSFSECS. The phase encode direction was anterior–posterior for all T2WIs. The detailed acquisition parameters are provided in Table 1.
Lee H.K., Song J.S., Jang W., Nickel D, & Paek M.Y. (2022). Improved Single Breath-Hold SSFSE Sequence for Liver MRI Based on Compressed Sensing: Evaluation of Image Quality Compared with Conventional T2-Weighted Sequences. Diagnostics, 12(9), 2164.
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9

Liver MRI Protocol for TARE Response

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We analyzed the MRI closest to surgery (< 90 days) and we only included patients with a minimal delay of 12 weeks between TARE and imaging, so to assess the response adequately. However, most patients got a longer delay between TARE and surgery with multiple MRIs performed. Of those, only the last MRI before surgery (performed < 90 days before surgery) was considered for the present study.
MRI of the abdomen was performed using various 1.5-T/3.0-T clinical systems with abdominal phase-array coils, using parallel imaging with a field of view of 300-400mm (Magnetom Avanto [n = 6], Skyra [n = 8], Aera [n = 16], Siemens Healthineers; and Signa 1.5T [n = 17], GE Healthcare). The liver MRI was a standard-ofcare contrast-enhanced exam including dynamic phase images (pre-contrast, early and late arterial phases [AP], portal venous phase [PVP], transitional phase) as well as hepatobiliary phase (HBP) at 10 and 20 min post-injection of a fixed dose of 10 mL of gadoxetate disodium (Eovist/ Primovist, Bayer Healthcare). MRI protocol is presented in Table 1. Enhanced phases-precontrast image subtraction datasets were generated automatically for all MRI exams.
Vietti Violi N., Gnerre J., Law A., Hectors S., Bane O., Doucette J., Abboud G., Kim E., Schwartz M., Fiel M.I, & Taouli B. (2022). Assessment of HCC response to Yttrium-90 radioembolization with gadoxetate disodium MRI: correlation with histopathology. European radiology, 32(9).
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