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486 protocols using spss statistics for windows version 27

1

Body Composition and Disability Assessment

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Sample size was predetermined by the t-test sample size calculation, using IBM SPSS Statistics for Windows, version 27, based on the assumption that the minimum detectable difference between the two groups in percent body fat was 10%. A total of 64 patients were required, with a significance level of 0.05 (α = 0.05) and a power of 80% (β = 0.20). Considering the predicted dropout rate, the total sample size was increased to 72.
All descriptive data are expressed as the number of patients, mean ± SD, and median [interquartile range]. Continuous variables were analyzed by a two-tailed t-test or Mann—Whitney rank-sum test after a normality test. The χ2 test was used to compare categorical variables. Linear regression analysis was performed to verify the relationships between body composition parameters and the ODI scores. A p-value of less than 0.05 was considered statistically significant. All statistical analyses were performed using IBM SPSS Statistics for Windows, version 27.
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2

Outcomes of Aneurysmal Subarachnoid Hemorrhage

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Between January 2012 and December 2020, 506 patients suffering from spontaneous aneurysmal SAH were admitted to our institution. SAH was diagnosed by computer tomography (CT) or lumbar puncture. All patients with spontaneous SAH underwent four-vessel digital subtraction angiography (DSA) to identify the source of bleeding. We excluded all patients with traumatic origin of SAH. Clinical data, including patient characteristics on admission and during the treatment course, radiological features (including Fisher scale) and functional neurological outcome were collected and entered into computerized database (IBM SPSS Statistics for Windows, Version 27.0., Armonk, NY, USA: IBM Corp.). The World Federation of Neurological Surgeons (WFNS) scale was used to grade patients on admission [9 (link)]. WFNS grades 1–3 were considered “good grade SAH”, and WFNS grades 4–5 were considered “poor-grade SAH”.
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3

Kynurenine Pathway Metabolites in Experimental Groups

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The results are given as mean (SD), median (min; max) and number (proportion in percentage). Some results are given both as mean (SD) and median (min; max) to present deviations from normal distributions. All analyses were performed on original data, and some analyses were also performed on logarithmic (ln) transformed data because of deviations from a normal distribution. The levels of the KP metabolites in the E-groups and comparisons between the E-groups were analysed with a linear mixed model and reported as estimated marginal means with 95% confidence intervals (CI) and p-values. To account for the KP-metabolites’ deviations from a normal distribution, the pairwise comparisons between the E-groups were analysed with a linear mixed model based on 10,000 bootstrap samples and reported as the differences between the mean values with a 95%CI (percentile) and p-values. Statistical analyses were performed with IBM Corp. Released 2020: IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY, USA: IBM Corp. To reduce the possibility of type 1 errors, p ≤ 0.01 was chosen as statistically significant in this explorative study with multiple tests.
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4

Gestational Age and Birth Weight Analysis

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Descriptive statistics were used for representing the demographic variables. Kruskal‐Wallis test was used for the comparison of numerical variables and the Jonchkheere‐Terpstra test was used for evaluating trends in the numerical variables across different categories of gestational age and birth weight. Pearson correlation tests were carried out for assessing the significance of the association between the numerical variables. Linear regression was used for evaluating the relationship between the predicted concentrations and the body weight (continuous variable). Bootstrapping simulations in 1000 samples were used for confirming the regression coefficient and P‐values. Mann‐Whitney U test was used for comparing the transformed values following linear regression with the original values for the predicted concentrations. Bonferroni corrected P‐values were used for evaluating the statistical significance. A P‐value of ≤ 0.05 was considered significant. SPSS (IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp.) was used for statistical analysis.
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5

Videocapillaroscopy in COVID-19 Patients

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Categorical variables were reported as number and percentage, and continuous variables as median and range (min–max). We used the non-parametric test of Spearman’s Rho to evaluate the correlations between videocapillaroscopic alterations and clinical and laboratory parameters as well as biomarkers of inflammation, coagulation and endothelial dysfunction. Differences between COVID-19 patients vs. healthy subjects as well as within COVID-19 patients with or without ANA positivity, and with O or non-O blood groups were evaluated by the non-parametric test of Mann–Whitney U test. Differences in percentage of videocapillaroscopic alterations were evaluated by means of chi-square test. Statistical significance was defined as a p-value < 0.05.
The sample size of patients included in the present study allowed to obtain a statistical power of 80% with an alpha error of 0.05, based on the study by Ingegnoli et al. [23 (link)] considering a frequency of 2% of hemosiderin deposits in healthy subjects. Data were analyzed using IBM SPSS Statistics v27.0 (IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY, USA: IBM Corp.).
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6

Statistical Analysis of Continuous Data

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The Kolmogorov-Smirnov test, skewness and visual interpretation of histograms were used to assess normality of continuous data. The Mann-Whitney U test for non-normally distributed variables was used for comparisons of scores between the groups, and the Wilcoxon signed-ranks tests was used to compare paired scores. The Spearman correlation coefficient was used for assessing the linear relationship between scales. Differences were considered significant at a P value of <0.05. Statistical analyses were performed with IBM SPSS Statistics Version 27 (IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp).
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7

Statistical Analysis of Clinical Outcomes

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Sample distribution was evaluated with Kolmogorov–Smirnov and Shapiro–Wilk tests. Continuous variables were compared by Kruskall–Wallis or ANOVA when appropriate, while categorical variables were analyzed using Pearson’s chi-squared test. Tests were adjusted for all pairwise comparisons using the Bonferroni correction.
Survival curves were obtained through the Kaplan–Meier method, and log-rank test was used to evaluate differences in cumulative survival among groups. A logistic regression model was built to detect independent predictors of outcome and to estimate the adjusted odds ratio (OR) and 95% confidence interval (95% CI). Only significant (p < 0.1) variables in the univariate analysis were included in the multivariate model. The median period of follow-up was calculated through the reverse Kaplan–Meier method. p values below 0.05 were considered statistically significant. Data were recorded in a computerized spreadsheet (Microsoft Excel 2016; Microsoft Corporation, Redmond, WA, USA) and analyzed with statistical software (IBM Corp., released 2021, IBM SPSS Statistics for Windows, Version 27.0; Armonk, NY, USA, IBM Corp.).
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8

Correlating Lymphoma SUVmax Parameters

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Collected data were coded and tabulated, then statistical analysis was done using MedCalc Statistical Software version 19.2.6 (MedCalc Software bv, Ostend, Belgium; https://www.medcalc.org; 2020) and IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp.
Descriptive analysis was done for numerical variables and was presented as mean ± standard deviation (SD). Categorical variables (qualitative data) were presented as number and percentage. Pearson's correlation analysis (r) was used to evaluate coefficient of correlation between the SUVmax of the hottest LN and the SUV max of EN sites of lymphoma followed by the mbSUVmax and lvSUVmax values of the same, r = 0–0.2 (poor correlation), 0.2–0.5 (moderate), 0.5–0.7 (strong), and 0.7–0.9 (very strong).
In view of small sample size, one- and two-tailed t-test for paired samples at 5% and 10% significance level was then conducted to validate the significance of the Pearson's correlation coefficients.
Two-tailed t-test for independent samples at 5% and 10% significance level was also used to compare means of absolute and normalized SUVmax values between data grouped according to gender and histopathological subtypes (NHL and HL).
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9

Anti-HCV Seroprevalence in Birth Cohort and Risk Groups

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Data aggregated by sex and ten-year age groups regarding screened and seropositive individuals in the birth cohort and risk group (PWID or individuals living with HIV), were received from the National Health Insurance Fund. Anti-HCV seroprevalence was assessed as the number of individuals with positive test results divided by the number of all screened individuals. The proportion of anti-HCV seropositive individuals in different sex and age groups was compared using a χ2 test, Z-test with Bonferroni correction for multiple comparisons and a Fisher Exact test. Data analysis was performed using the statistical package IBM SPSS Statistics for Windows, Version 27.0 (IBM Corp.: Armonk, NY, USA, released 2020).
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10

Clinicians' Perceptions of AI in Practice

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Online access to the form and answers was restricted to the principal investigator (C.G.) and two members of the research group (S.L. and G.C.) who were in charge of data elaboration. Five sections were investigated: socio-demographic data (including the age and sex of participants and the country where they practiced), ‘professional profile’ (specialty, academic position and working environment), ‘use of AI in clinical practice’, ‘potential applications of AI’ and its ‘perceived relevance’. The complete list of survey questions and multiple-choice answers is reported in Table S1.
SPSS version 27 software was used for statistical analysis (IBM Corp., released in 2020, IBM SPSS Statistics for Windows, Version 27.0, Armonk, NY, USA: IBM Corp), which involved descriptive and inferential statistics. Fisher’s exact test was used to infer the association between the use of AI (dependent variable) and variables among specialty, academic profile, age, country and academic qualification; Cramer’s V was used for the estimation of the effect size. A threshold of p ≤ 0.05 was set for statistical significance.
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