Thirty minutes before intravenous injection of 18F‐FLT (5 MBq in 50 μL saline) or 123I‐ITdU (10 MBq in 100 μL saline), FdUrd (5 mg/kg in 50 μL saline) was injected into the lateral tail vein of NOD SCID mice bearing xenotransplanted IGR‐37 tumors. The biodistribution of 18F‐FLT was evaluated 60 min p.i. by using the microPET (Inveon, Simens, Knoxville). CT images were produced by a Philips Gemini TF16 PET/CT (Philips Medical Systems, Best, The Netherlands). The PET images were reconstructed using the iterative OSEM3D/MAP (OSEM3D 2 iterations, MAP 18 iterations) algorithm. The biodistribution of 123I‐ITdU was evaluated 4 and 24 h p.i. by using a clinical dual‐head SPECT Siemens E.cam gamma camera equipped with μSPECT pinhole collimators. Subsequent CT images were produced by a Philips Gemini TF 16 PET/CT. The corresponding SPECT images were reconstructed using an iterative OSEM (5 iterations, 16 subsets) algorithm representing activity concentrations in units of kBq/cc. Calculation of activity uptake values (kBq) was performed by VOI definition in tumor, liver, and spleen as well as percentage uptake related to the injected activity.
Gemini tf 16 pet ct
Manufactured by Philips
Sourced in Netherlands
The Gemini TF 16 PET/CT is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. It is designed to acquire and integrate high-quality 3D images of the body's anatomy and physiology for diagnostic and treatment planning purposes.
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17 protocols using gemini tf 16 pet ct
1
Evaluating Radiolabeled Probes for Tumor Imaging
2
Standardized 18F-FDG PET/CT Imaging Protocol
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Patients were instructed to fast for at least 6 hours prior to undergoing PET/CT scan. The images were acquired approximately 60 minutes after an injection of 3.7 MBq/kg 18F-FDG. A whole-body acquisition was commenced in 6−8 bed positions (1 min/bed) using a hybrid system (Gemini TF 16 PET/CT, Philips, Netherlands), covering from the base of the skull to the upper thigh. CT was conducted using the following parameters: 120 kV, 100 mAs, and slice thickness of 3 mm for attenuation correction and anatomical localization. Two experienced nuclear medicine physicians who were blinded to the findings of clinical and prognostic information have reported 18F-FDG-PET/CT images by reaching consensus. The SUVmax generated from each patient was used in the final analysis.
3
PET/CT Brain Imaging Protocol
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PET scans were executed 30–40 min after 18F-FDG administration (3.7 MBq/kg) according to EANM guidelines for brain imaging. Images were obtained on a PET/CT scanner (Philips Gemini TF 16 PET/CT) and reconstructions were performed using 3D LOR iterative algorithm reconstruction (FOV: 256, matrix: 128 × 128, voxel dimensions: 2 × 2 × 2 mm). CT acquisition for attenuation correction was performed on spiral 16 slices CT with a slice thickness of 2 mm.
4
Whole-Body PET/CT Imaging with 18F-FDG
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PET/CT of the whole body was acquired on a Gemini® TF 16 PET/CT (Philips, Best, the Netherlands) 60 min after the application of 18F-fluorodeoxyglucose (2–2.5 MBq/kg). A fasting period of more than six hours before application was mandatory for all patients. For attenuation correction, low dose CT without application of contrast media was used.
5
FDG-PET/CT Imaging Protocol for Lymphoma Staging and Response Evaluation
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Patients were instructed to fast for at least 6 h before injection of 3.7 MBq/kg 18F-FDG intravenously. Approximately 60±10 min post-injection, a whole-body acquisition commenced in 6−8 bed positions (1 min/bed) using a hybrid system (Gemini TF 16 PET/CT, Philips, Netherlands), and covered from the base of the skull to the upper thigh. Non-contrast enhanced CT was conducted using the following parameters: modulated 100 mAs, 120 kV, and slice thickness 3 mm for attenuation correction and anatomical localization.
PET findings were interpreted based upon Deauville criteria (5-point scale). A score of ≤3 was interpreted as negative, and a score of >3 was interpreted as positive ( 11 (link)). Clinical efficacy of complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD) was defined according to the Lugano classification (11 (link)).
PET findings were interpreted based upon Deauville criteria (5-point scale). A score of ≤3 was interpreted as negative, and a score of >3 was interpreted as positive ( 11 (link)). Clinical efficacy of complete response (CR), partial response (PR), stable disease (SD), or progressive disease (PD) was defined according to the Lugano classification (11 (link)).
6
Whole-body 18F-FDG PET/CT Imaging Protocol
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All patients fasted for at least 4 h before examination, with blood glucose levels < 170 mg/dL. Images from the mid-skull to pelvis were obtained using a dedicated PET/CT scanner (Philips Gemini TF 16 PET/CT), 60 min after intravenous injection of 3.7 MBq/kg of 18F-FDG. Before the PET scans, a low-dose CT (120 kV; 50–80 mA) was acquired to allow attenuation correction and lesion localization. PET images were reconstructed using an iterative algorithm (3D LOR RAMLA reconstruction with TOF, FOV: 576, matrix: 144 × 144, voxel dimension: 4 × 4 × 4 mm). Fused images of matching pairs of PET and CT images were available for review in axial, coronal and sagittal planes and in maximum intensity projections (MIPs).
7
Macaque Chest CT Imaging Protocol
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Chest CT scans were performed using the 16-slice CT component of a Gemini TF 16 PET/CT (Philips Healthcare, Cleveland, OH, USA) or a Precedence SPECT/CT scanner (Philips Healthcare). Chest CT images were acquired in helical scan mode with the following parameter settings: ultra-high resolution, 140 kVp, 300 mAs/slice, 1 mm thickness, 0.5 mm increment, 0.688 mm pitch, collimation 16×0.75, and 0.75 s rotation. CT image reconstruction used a 512×512 matrix size for a 250-mm transverse field-ofview (FOV), leading to a pixel size of 0.488 mm. Two CT images were produced: one with the standard “B” filter and one with the bone-enhanced “D” filter. No contrast agent was administered. Each macaque underwent a 15–20-s breath-hold during acquisition. The pressure for the breath-hold was maintained at 150 mmH2O.
8
FDG-PET Imaging Protocol for Cancer Assessment
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FDG-PET examinations were performed according to the European Association of Nuclear Medicine guidelines[22 (link)] and acquired using a 16-slice PET/CT hybrid system (Philips Gemini TF 16 PET/CT). Briefly, patients were instructed to fast at least 4 h prior to the intravenous administration of 350–450 MBq of FDG. Blood glucose level was measured before tracer injection so as to ensure levels <160 mg/dl. Imaging started 60 ± 15 min after intravenous tracer administration. Unenhanced low-dose CT was performed at 120 kV and 50 mA for attenuation correction of emissive data and anatomical localization of PET data set. Emissive scan was performed in three-dimensional (3D) mode, shortly after CT acquisition, with a 2-min acquisition per bed position and field of view of 576 cm. PET images were reconstructed using an iterative reconstruction algorithm (3D LOR RAMLA), matrix 512 × 512, voxel size of 4 mm × 4 mm × 4 mm.
Scans were performed starting from the orbital plane on to the mid-thigh, except for the cases where the clinical history demanded a whole-body, vertex-to-toes scan.
PET images were qualitatively interpreted according to Juweid criteria at the time of PET examination.
Moreover, FDG-PET examinations were retrospectively re-evaluated using Deauville 5-point scale by an experienced reader blinded from qualitative interpretation and patients' follow-up data.
Scans were performed starting from the orbital plane on to the mid-thigh, except for the cases where the clinical history demanded a whole-body, vertex-to-toes scan.
PET images were qualitatively interpreted according to Juweid criteria at the time of PET examination.
Moreover, FDG-PET examinations were retrospectively re-evaluated using Deauville 5-point scale by an experienced reader blinded from qualitative interpretation and patients' follow-up data.
9
Prone vs. Supine FDG PET/CT for Breast Imaging
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Patients were instructed to fast for at least 6 h before the injection of FDG. Blood glucose levels were measured before injection, and the injected activity ranged between 185–296 MBq. After injection, patients were kept lying comfortably. The whole-body FDG PET/CT in supine position was performed approximately 60 min after injection using a Philips Gemini TF 16 PET CT. The time per frame of PET scan was 2 min/frame for all patients in supine and prone acquisition. The CT images were first acquired, followed by the PET study. After completion of the PET acquisition, images were attenuation-corrected, then fused with the CT images. This protocol was applied for both prone and supine position acquisitions. After supine acquisition, patients were then positioned in prone for breast PET/CT acquisition. This was performed 10 min at most after completion of supine acquisition in order to minimize time differences, which may influence image parameters such as SUVmax and tumor-to-background ratios. During prone acquisition, the patient’s breasts were positioned in a custom-built mattress made of poly foam and plexi-glass covered with leather, designed and produced at AUBMC, and the patients’ arms were elevated above the head. Images were reconstructed to a high resolution of 2 mm slice thickness.
10
FDG-PET/CT Imaging Protocol for Cancer
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Patients were asked to fast for at least 6 h before examination, and serum glucose
levels were confirmed to be below 160 mg/dL. PET/CT scanning was performed on a
Gemini 64 TF scanner (Philips, The Netherlands) 40-60 min after intravenous FDG
administration (3.7-4.4 MBq/kg). Non-contrast CT images were obtained with a
multi-detector spiral CT scanner (Philips Gemini TF 16 PET/CT) immediately prior to
PET scanning with an acquisition time of 1.5 min/bed position during shallow
breathing. The scan field was from the vertex to the upper thighs. PET data were
reconstructed using an ordered-subset expectation maximization algorithm. CT data
were used for attenuation correction and anatomic localization. Co-registered images
were displayed by means of the SYNTEGRA software (Philips).
PET/CT results were interpreted by two experienced nuclear medicine physicians in a
blinded manner. SUVmax and SUVavg were determined by drawing a
region of interest (ROI) around the primary tumor on the transaxial slices and
calculating values with the following equation: tumor activity concentration/injected
dose/body weight. SUVT/L and SUVT/A were defined as primary
tumor SUVmax divided by liver SUVmax and aorta blood pool
SUVmax, respectively.
levels were confirmed to be below 160 mg/dL. PET/CT scanning was performed on a
Gemini 64 TF scanner (Philips, The Netherlands) 40-60 min after intravenous FDG
administration (3.7-4.4 MBq/kg). Non-contrast CT images were obtained with a
multi-detector spiral CT scanner (Philips Gemini TF 16 PET/CT) immediately prior to
PET scanning with an acquisition time of 1.5 min/bed position during shallow
breathing. The scan field was from the vertex to the upper thighs. PET data were
reconstructed using an ordered-subset expectation maximization algorithm. CT data
were used for attenuation correction and anatomic localization. Co-registered images
were displayed by means of the SYNTEGRA software (Philips).
PET/CT results were interpreted by two experienced nuclear medicine physicians in a
blinded manner. SUVmax and SUVavg were determined by drawing a
region of interest (ROI) around the primary tumor on the transaxial slices and
calculating values with the following equation: tumor activity concentration/injected
dose/body weight. SUVT/L and SUVT/A were defined as primary
tumor SUVmax divided by liver SUVmax and aorta blood pool
SUVmax, respectively.
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