Implant removal was performed surgically 3, 6-, or 9-months following implantation. Removals occurred throughout the year and were equally divided between seasons of increasing and decreasing photoperiods. Tomcats were anaesthetized with 0.008 mg/kg of dexmedetomidine, 2 mg/kg of ketamine (Imalgene 1000™; Merial, Padova, Italy) and 0.3 mg/kg of butorphanol (Dolorex™; MSD, Rome, Italy), administered by intramuscular injection and propofol (Proposure™; Merial, Padova, Italy) administered intravenously to effect when required. Once the implant was located by palpation of the periumbilical skin, a 2 cm incision was performed just above the implant following disinfection and scrubbing of the surgical area. Subsequently, the implant was gently pulled out taking care not to rupture it. Following removal, the incision was closed with an intradermal suture using absorbable material (3/0 Monosyn™; Braun, Milan, Italy). At time of implant removal, a GnRH stimulation test (administering 50 μg gonadorelin prior to surgery and collecting a blood sample 60 min later) and an ultrasound evaluation with measurement of both testicles were performed.
Dolorex
Manufactured by MSD
Sourced in Italy, United States, Netherlands, Greece
Dolorex is a lab equipment product designed for precise measurement and analysis. It functions as a specialized device for conducting experiments and data collection.
Automatically generated - may contain errors
Lab products found in correlation
Rompun, by Bayer (2 mentions)
Propofol 1 mct lct, by Fresenius (2 mentions)
Isoflo, by Abbott (2 mentions)
Rimadyl, by Zoetis (2 mentions)
Tetracaine, by Bausch & Lomb (1 mentions)
Oxybuprocaine hydrochloride, by Bausch & Lomb (1 mentions)
Ketaminol vet, by MSD (1 mentions)
Mydriacyl, by Bausch & Lomb (1 mentions)
Metaoxidrin, by Bausch & Lomb (1 mentions)
Zoletil 50 vet, by Virbac (1 mentions)
Rompun vet, by Bayer (1 mentions)
Zoletil, by Virbac (1 mentions)
Synulox rtu inj 100 ml, by Zoetis (1 mentions)
Zoletil 100, by Virbac (1 mentions)
6 protocols using dolorex
1
Surgical Removal of Implants in Tomcats
2
Anesthesia Protocol for Porcine Retinal Imaging
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Thirteen female Danish Landrace pigs of approximately 20 kg were used for this experiment. All animals were anesthetized with an intramuscular injection of 5 mL Zoletil 50 Vet (a mixture of tiletamine 6.25 mg/mL and zolazepam 6.25 mg/mL; Virbac, Carros, France), ketamine 6.25 mg/mL (Ketaminol Vet; MSD, Rahway, NJ, USA), butorphanol 1.25 mg/mL (Dolorex; MSD, Rahway, NJ, USA), and xylain 6.25 mg/mL (Rompun Vet; Bayer, Leverkusen, Germany. The eyes were anesthetized with oxybuprocaine hydrochloride 0.4% (Bausch & Lomb, Rochester, NY, USA) and tetracaine 1% (Bausch & Lomb, Rochester, NY, USA), followed by dilatation with tropicamide 0.5% (Mydriacyl; Bausch & Lomb, Rochester, NY, USA) and phenylephrine 10% (Metaoxidrin; Bausch & Lomb, Rochester, NY, USA). To prevent the corneal surface from drying and, thereby, compromising the view of the retina, Systane Ultra eye drops (Polyethylene Glycol 400, Propylene Glycol; Alcon, Copenhagen, Denmark) were applied regularly. This study was approved by the Danish Animal Experiments Inspectorate (permission number 2019-15-0201-01651).
3
Xylazine-Butorphanol Premedication for Orthopedic Surgery
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Premedication including xylazine (Rompun® 20 mg/ml, Bayer, 0,1 mg/kg) and butorphanol (Dolorex® 10 mg/ml, MSD, 0,05 mg/kg) was administered intramuscularly, allowing sedation and trichotomy of both hind limbs. Iodopovidone at 10% (Betadine®) and 70% ethanol were employed at the surgical field. Intraoperatively, intravenous fluid was provided at maintenance rate (NaCl 0,9% B Braun®) and general anaesthesia was induced with intravenous tiletamine-zolazepam (Zoletil®, 100 mg/ml, Virbac, 3 mg/kg). Monitoring of anaesthesia included cardiorespiratory parameters and bolus of tiletamine-zolazepam whenever required. Loco-regional anaesthesia was performed with lidocaine hydrochloride (Anestesin® 2%, 20 mg/ml, Medinfar-Sorológico) administration using an epidural spinal catheter between L6 and S1.
4
Anesthetic Regimen for Feline Procedure
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Cats were premedicated with dexmedetomidine (20 μg/kg, intramuscularly [IM], Dexdomitor 0.5 mg/mL; Elanco, Greece) and butorphanol (0.3 mg/kg, IM, Dolorex, 10 mg/mL; MSD, Netherlands). Anesthesia was induced with 1% propofol (2–4 mg/kg, intravenously [IV], Propofol-MCT/LCT 1%; Fresenius Kabi Hellas, Greece) and maintained with isoflurane (1∼2%, Isoflo; Abbott Laboratories, UK) in oxygen (2 L/min). A 0.9% sodium chloride solution (NS 0.9%) IV was administered at 4 mL/kg/h during anesthesia. Preoperatively, amoxycillin, clavulanic acid (20 mg/kg, subcutaneously [SC], Synulox RTU Inj. 100 mL; Zoetis, Greece) and carprofen (2 mg/kg, IV, Rimadyl; Zoetis, Greece) were administered.
5
Anesthetic protocol for feline surgery
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The cats were premedicated with dexmedetomidine (20 μg/kg, intramuscularly [IM], Dexdomitor 0.5 mg/mL; Elanco, Greece) and butorphanol (0.3 mg/kg, IM, Dolorex 10 mg/mL; MSD, Greece). Anesthesia was induced with propofol 1% (2–4 mg/kg, intravenously [IV], Propofol MCT/LCT 1%; Fresenius Kabi Hellas, Greece) and maintained with isoflurane (2%, Isoflo; Abbott Laboratories, UK) in oxygen (2 L/min). An NS 0.9% solution IV was administered at 4 mL/kg/h during anesthesia. Preoperatively, amoxicillin and clavulanic acid (20 mg/kg, subcutaneously [SC], Synulox RTU Inj. 100 mL; Zoetis, Greece) and carprofen (2 mg/kg, IV, Rimadyl; Zoetis) were administered.
6
Multimodal Anesthesia for Surgical Procedures
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Multimodal anaesthesia was employed, and premedication was administered intramuscularly into the lumbar muscles using xylazine (Rompun® 20 mg/ml, Bayer, 0.1 mg/kg), together with butorphanol (Dolorex® 10 mg/ml, MSD, 0.05 mg/kg). Initial sedation allowed trichotomy of the hind limb. Initial antisepsis of the surgical site was performed with 4% iodopovidone (Betadine®) scrub solution. Intraoperative intravenous fluid therapy (NaCl 0.9% B Braun®) at a maintenance rate was provided. Induction of general anaesthesia was performed by intravenous bolus administration of tiletamine-zolazepam (Zoletil®100, Virbac, 5.5 mg/kg). Loco-regional anaesthesia was provided using lidocaine hydrochloride (Anestesin® 2%, Medinfar-Sorológico) administered via an epidural spinal catheter. Final antiseptic preparation of the operative field was performed with the animal in lateral recumbency using 70% ethanol (Aga) and 10% iodopovidone topical solution. Anaesthetic monitoring of cardiorespiratory parameters was performed and recorded, while intravenous top-up bolus of tiletamine-zolazepam was administrated intraoperatively whenever required.
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