Selactar

Manufactured by Bayer

Sourced in Japan, Germany

The Selactar is a laboratory equipment designed for the separation and isolation of biological samples. It utilizes centrifugal force to separate components within a liquid mixture based on their density differences. The core function of the Selactar is to provide a reliable and efficient means of sample preparation for further analysis or experimentation.

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Lab products found in correlation

Ketalar, by Daiichi Sankyo (7 mentions) Isoflurane, by Pfizer (2 mentions) Zoletil 100, by Virbac (1 mentions) Lidocaine hydrochloride, by AstraZeneca (1 mentions) Xylocaine, by AstraZeneca (1 mentions) Benoxil ophthalmic solution 0.4, by Santen (1 mentions) Ketaral, by Daiichi Sankyo (1 mentions) Rh 795, by Thermo Fisher Scientific (1 mentions) 3 0 silk suture, by Johnson & Johnson (1 mentions) Zoletil, by Virbac (1 mentions) Aquilion lb, by Canon (1 mentions) Urethane, by Merck Group (1 mentions) Ultrasound gel, by Parker Laboratories (1 mentions) Forane, by Abbott (1 mentions) Midorin p, by Santen (1 mentions)

16 protocols using selactar

Anesthetic Immobilization Protocol for Wildlife

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For anesthesia, we administered xylazine HCl (0.8 to 1.2 mg/kg; Selactar; Bayer, Tokyo, Japan) and a 1:1 mixture of zolazepam HCl and tiletamine HCl (2.0 to
4.0 mg/kg; Zoletil 100; Virbac, Carros, France) via intramuscular injection using blow darts. After examination, atipamezole HCl (at the same volume as
xylazine; Atipame; Kyoritsu, Tokyo, Japan) was injected and recovery from anesthesia was observed.

TORII Y., MATSUMOTO N., SAKAMOTO H., NAGANO M., KATAGIRI S, & YANAGAWA Y. (2020). Monitoring follicular dynamics to determine estrus type and timing of ovulation induction in captive brown bears (Ursus arctos). The Journal of Reproduction and Development, 66(6), 563-570.

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Beagle Dog Premolar Extraction

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In order to make the region for defect creation, 4^th premolars were extracted. Beagle dogs were administered 2% Xylazine (Selactar, Bayer Yakuhin Ltd., Osaka, Japan, 1 mL/ body, intramuscularly) and pentobarbital (Nacalai tesque, Kyoto, Japan, 30 mg/kg, intravenously) for general anesthesia and 2% lidocaine with 0.00125% adrenaline (Xylocaine, Dentsply-Sankin K.K., Tokyo, Japan, 0.9 mL/site, intragingivally). Under anesthesia, the 4^th premolars were split through the furcation into two mesiodistal portions and removed using standard methods.

Anzai J., Nagayasu-Tanaka T., Terashima A., Asano T., Yamada S., Nozaki T., Kitamura M, & Murakami S. (2016). Long-term Observation of Regenerated Periodontium Induced by FGF-2 in the Beagle Dog 2-Wall Periodontal Defect Model. PLoS ONE, 11(7), e0158485.

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Isolation and Analysis of Bovine Corpus Luteum

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The collection procedures were approved by the local institutional Animal Care and Use Committee of the Polish Academy of Sciences in Olsztyn, Poland (Agreement No. 5/2007 , 6/2007 and 88/2007) . Twenty-five healthy, normally cycling Polish Holstein black and white cows (control, n = 5; 2 h, n = 5; 4 h, n = 4; 12 h, n = 6; 24 h, n = 4) were used for collection of CL. These cows were multiparous and non-lactating. Oestrus was synchronised by two injections of 25 mg PGF2α (Dinoprost, Dinolytic; Pharmacia and Upjohn, Puurs, Belgium) at 11-day intervals according to the manufacturer's instructions. Ovulation was determined by a veterinarian via transrectal ultrasonography before the second injection. Cows were sedated by injection of xylazine hydrochloride (2% Selactar; Bayer, Leverkusen, Germany), followed by injection of a local anaesthetic (lidocaine hydrochloride; 2% Xylocaine; AstraZeneca, London, UK). Then, ovaries were collected by colpotomy using Hauptner's effeminator (Hauptner and Herberholz; Solingen, Germany; http://www.hauptner-herberholz.de, accessed 23rd April 2016) on Day 10 after ovulation before and after injection of a luteolytic dose (25 mg) of a PGF2α. CL tissues were dissected from the ovaries and then immediately stored at -80°C until processing for mRNA and protein analysis.

Horihata K., Yoshioka S., Sano M., Yamamoto Y., Kimura K., Skarzynski D.J, & Okuda K. (2017). Expressions of lipoprotein receptors and cholesterol efflux regulatory proteins during luteolysis in bovine corpus luteum. Reproduction, fertility, and development, 29(7).

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Intravitreal Delivery of tm-scAAV2-BDNF and NMDA in Mice

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Mice were anesthetized by intraperitoneal administration of ketamine/xylazine (Ketaral, 100 mg/kg, Daiichi Sankyo Co., Ltd., Tokyo, Japan; Selactar, 10 mg/kg, Bayer Medical, Ltd., Tokyo, Japan). After a topical application of 0.4% oxybuprocaine hydrochloride (Benoxil^® ophthalmic solution 0.4%, Santen Pharmaceutical Co., Ltd., Osaka, Japan), tm-scAAV2-BDNF and its control AAV were injected intravitreally using 33-gauge Hamilton needles and syringes. Each eye received 1 μl of the vector at a titer of 6.6 E+13 genome copies/mL, as previously described [37 (link)]. Three weeks later, 1 μl of 2 mM NMDA (Wako Pure Chemical Industries, Ltd., Osaka, Japan) was administered intravitreally in the same way as the viral injection.

Shiozawa A.L., Igarashi T., Kobayashi M., Nakamoto K., Kameya S., Fujishita S., Takahashi H, & Okada T. (2020). Tyrosine triple mutated AAV2-BDNF gene therapy in an inner retinal injury model induced by intravitreal injection of N–methyl-D-aspartate (NMDA). Molecular Vision, 26, 409-422.

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Voltage-Sensitive Dye Imaging of Auditory Cortex

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Imaging was conducted from both hemispheres. After completion of imaging from one hemisphere, the second craniotomy was started for the other hemisphere. Animals were initially anesthetized with a mixture of ketamine and xylazine (i.m., 80 mg/kg, Ketalar, Daiichi-Sankyo, and 25 mg/kg, Selactar, Bayer Yakuhin, respectively), placed under a measuring microscope in a soundproof room, and artificially ventilated after injection of the muscle relaxant pancuronium bromide (i.m., 1 mg/kg, Myoblock, MSD). The auditory cortex exposed by craniotomy was stained with the voltage-sensitive dye RH795 (Invitrogen) for 60–90 min. Heart rate and body temperature were continuously monitored. A supplemental dose of anesthetics (25 mg/kg Ketalar and 10 mg/kg Selactar) and the muscle relaxant (1 mg/kg Myoblock) was administered every 60–120 min. Animals were euthanized with pentobarbital (i.p., 60 mg/kg, Somnopentyl, Abbott) or ketamine (intracardiac, 160 mg/kg) after completion of the experiment.

Horikawa J, & Ojima H. (2017). Cortical Activation Patterns Evoked by Temporally Asymmetric Sounds and Their Modulation by Learning. eNeuro, 4(2), ENEURO.0241-16.2017.

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Tibial Nerve Regeneration Using Microfibrous Conduits

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Electrospun microfibrous conduits were implanted into 2.0-cm gaps in the left tibial nerve of a total of 12 New Zealand white rabbits (3.0–3.5 kg, male) (Oriental Yeast Co., Ltd., Tokyo, Japan). This study was performed in accordance with the animal experimental guidelines of the National Cerebral and Cardiovascular Center Research Institute. Rabbits were anesthetized by intramuscular injection of 0.1 mL/kg of Selactar (Bayer Yakuhin, Ltd., Osaka, Japan) and anesthesia was maintained by inhalation of 3% Escain isoflurane (Mylan Inc., Canonsburg, PA, USA). Under an operating microscope, the left tibial nerve was exposed and a 2.0-cm segment was removed. A section of microfibrous conduit was filled with physiological saline solution and sutured with 10-0 vicryl (Ethicon, Somerville, NJ, USA) to bridge the gap between the proximal and distal stumps. Both nerve stumps were pulled 1.0 mm inside the conduits. In addition, the removed nerve tissue was inverted on its proximal–distal axis and implanted as an autograft control. Muscle and skin were closed with 3-0 silk sutures (Ethicon), and the rabbits were allowed to recover in a controlled environment.

Kakinoki S., Nakayama M., Moritan T, & Yamaoka T. (2014). Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid). Frontiers in Chemistry, 2, 52.

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Anesthetic Protocol for Rabbit Studies

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A total of six male New Zealand White rabbits (16 weeks old; weight, 2.84–3.44 kg; median, 3.16 kg) housed in the same environment were evaluated. All animal experiments were approved by the Toho University Laboratory Animal Research committee (19-53-358) and performed in accordance with the Guiding Principles for the Care and Use of Laboratory Animals approved by The Japanese Pharmacological Society and the tenets of the Association for Research in Vision and Ophthalmology.
The experiments were performed with the rabbits under general anesthesia, with induction of anesthesia by ketamine (Ketalar, 35 mg/kg, intramuscular [i.m.]; Daiichi Sankyo Propharma, Tokyo, Japan) and xylazine (Selactar 2%, 5 mg/kg, i.m.; Bayer Japan, Osaka, Japan) and maintenance with isoflurane (end-tidal concentration of 1.5%; Pfizer Japan, Tokyo, Japan). After intubation of the tracheal cannula, the rabbit was mechanically ventilated (FiO₂ = 1.0; tidal volume = 6 mL/kg, 40 strokes/min; SN-480-5, Shinano, Tokyo, Japan), and its body temperature was maintained at 37°C using a heating pad. The right ear vein was used for the administration of adrenaline, and the left ear vein was used for continuous maintenance infusions of saline (15 mL/h) and rocuronium bromide (0.6 mg/kg/h; Fuji Pharma, Toyama, Japan).

Komatsu T., Shiba T., Watanabe K., Sakuma K., Aimoto M., Nagasawa Y., Takahara A, & Hori Y. (2021). Real-Time Evaluation of Regional Arterial Stiffening, Resistance, and Ocular Circulation During Systemic Administration of Adrenaline in White Rabbits. Translational Vision Science & Technology, 10(9), 11.

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Anesthetic Immobilization of Bears

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The bears were anesthetized by the intramuscular administration of 2.5–3.5 mg/kg (body
weight) of a 1:1 mixture of zolazepam HCl and tiletamine HCl (Zoletil; Virbac, Carros,
France) with either 0.03 mg/kg medetomidine HCl (Domitor; Orion Corporation Animal Health,
Turku, Finland) or 1 mg/kg xylazine HCl (Selactar; Bayer Healthcare, Leverkusen, Germany)
using blow darts. After sample collection, anesthesia was reversed by the intramuscular
administration of 0.03 mg/kg atipamezole HCl (Antisedan; Orion Corp. Animal Health).

TOMIYASU J., KONDOH D., YANAGAWA Y., SATO Y., SAKAMOTO H., MATSUMOTO N., SASAKI K., HANEDA S, & MATSUI M. (2018). Testicular regulation of seasonal change in apocrine glands in the back skin of the brown bear (Ursus arctos). The Journal of Veterinary Medical Science, 80(6), 1034-1040.

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Photothrombotic Stroke Induction in Rats

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Photothrombotic stroke was induced as described previously. 14 Rats were anesthetized with an intraperitoneal injection of ketamine hydrochloride (60 mg/kg; Ketalar; Daiichi-Sankyou, Tokyo, Japan)/xylazine hydrochloride (6.0 mg/kg; Selactar; Bayer Yakuhin, Osaka, Japan). The skull over the RFA and CFA was carefully thinned (center; RFA: 3.0 mm lateral, 2.0 mm rostral from bregma; CFA: 3.5 mm lateral, 2.0 mm caudal from bregma; radius: 2.0 mm) and illuminated for 10 minutes. During the first minutes of illumination, Rose Bengal (15 mg/kg; 184-00272; Wako Pure Chemical, Osaka, Japan) was injected via tail vein catheter. Stroke was induced in the RFA first, then in the CFA by repeating same procedure.

Okabe N., Himi N., Nakamura-Maruyama E., Hayashi N., Sakamoto I., Hasegawa T, & Miyamoto O. (2019). Very Early Initiation Reduces Benefits of Poststroke Rehabilitation Despite Increased Corticospinal Projections. Neurorehabilitation and neural repair, 33(7).

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Helical CT Imaging of Cryptorchid Bulls

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We used a 16-slice multidetector helical CT scanner (Aquilion LB, Canon Medical Systems,
Otawara, Japan). The scanning parameters were as follows: X-ray tube potential, 120 kV;
X-ray tube current, 300 mA; gantry rotation time, 0.5 sec; and slice thickness, 2.0–8.0
mm. These parameters were used based on our pilot study. All bulls were premedicated with
xylazine (Selactar; Bayer Yakuhin Ltd., Tokyo, Japan; 0.2 mg/kg IV) and general anesthesia
was maintained with Isoflurane (Isoflurane; Pfizer Inc., Tokyo, Japan.) through the
endotracheal tube. The lateral recumbent position with the affected side up was employed
during CT. If the bulls were suspected to have bilateral cryptorchidism, the right lateral
recumbent position was employed.

GODA Y., MIZUTANI S., MIZUTANI Y., KITAHARA G., SISWANDI R., WAKABAYASHI K., TORISU S., KANEKO Y., HIDAKA Y., OSAWA T., ASANUMA T., SATO R, & SATOH H. (2022). Usefulness of computed tomography for cryptorchidism in bulls. The Journal of Veterinary Medical Science, 84(10), 1430-1436.

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