20(S)-Protopanaxadiol (PPD) (purity>98.0%) was obtained from Xian Plant Bio-Engineering Co., Ltd. (Shaan Xi, China). PEG-8 Caprylic/Capric Glycerides (LAS), Labrafac CC and Lauoroglycol CC were obtained from Gattefosse Co. (Saint Priest, Cedex, France). Capmul MCM EP was obtained from ARITEC Co. (Columbus, OH, USA). Miglyol 812 N and Poloxamer 188 were gifts from OLEO Chemicals (Witten, Germany) and BASF Co. (Ludwigshafen, Germany), respectively. Limonene, Tween 20, Tween 80, polyethylene glycol 400 (PEG400) and isopropyl myristate were obtained from Sigma-Aldrich Co. (St. Louis, MO, USA). Cetyl palmitate was obtained from TCI (Tokyo Kasei, Japan). Strat-M™ was purchased from Merck Millipore (Billerica, MA, U.S.A.). HPLC-grade water, acetonitrile, and methanol were obtained from Thermo Fisher Scientific Co. (Pittsburgh, PA, USA).
Peg 8 caprylic capric glycerides
Manufactured by Gattefosse
Sourced in France
PEG-8 Caprylic/Capric Glycerides is a nonionic surfactant that functions as an emulsifier, solubilizer, and dispersing agent. It is a mixture of polyethylene glycol ethers of caprylic and capric acid glycerides.
Automatically generated - may contain errors
Lab products found in correlation
Acetonitrile, by Thermo Fisher Scientific (4 mentions)
Tween 20, by Merck Group (2 mentions)
Labrafac cc, by Gattefosse (2 mentions)
Pranoprofen, by Alcon (2 mentions)
Methanol, by Thermo Fisher Scientific (2 mentions)
Isopropyl myristate, by Merck Group (1 mentions)
Polyethylene glycol 400 peg 400, by Merck Group (1 mentions)
Strat m, by Merck Group (1 mentions)
Hplc grade water, by Thermo Fisher Scientific (1 mentions)
Tween 80, by Merck Group (1 mentions)
Limonene, by Merck Group (1 mentions)
Miglyol 812, by Merck Group (1 mentions)
Tryptone soy agar, by Thermo Fisher Scientific (1 mentions)
Sabouraud dextrose agar, by Thermo Fisher Scientific (1 mentions)
Methyl thiazolyl tetrazolium (mtt), by Thermo Fisher Scientific (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Pluronic f 127, by Merck Group (1 mentions)
Transcutol p, by Gattefosse (1 mentions)
Castor oil ricinus communis l, by Merck Group (1 mentions)
Phosphate buffer saline tablets ph 7, by Merck Group (1 mentions)
5 protocols using peg 8 caprylic capric glycerides
1
Protopanaxadiol Formulation Development
2
Formulation and Characterization of Topical Antimicrobial Agents
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Thymol (TH), Tween 20 (TW), poloxamer 188 (P), caprylic/capric triglyceride (Miglyol 812) (CCTG), benzalkonium chloride (BZ), glycerin (GLY), propylene glycol (PG), hydroxypropyl methylcellulose (HPMC), and poloxamer 407 (Pluronic®F127) (PP) were acquired from Sigma-Aldrich (Madrid, Spain). Glyceryl behenate (GBH) (Compritol CG 888 ATO), PEG-8 Caprylic/Capric Glycerides (PCCG), and Transcutol P® (Diethylene glycol monoethyl ether) were provided by Gattefossé (Cedex, France). Carbomer® 934 (Polyacrylic acid, CB) was purchased from Fagron Iberica (Barcelona, Spain). Double-distilled water was filtered through a Millipore filter (Molsheim, France). All other reagents used were of analytical grade.
DMEM (Dulbecco’s Modified Eagle’s medium) was purchased from ThermoFisher, MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) from Sigma-Aldrich (St. Louis, MO, USA) and DMSO (99% dimethyl sulfoxide) from Sigma-Aldrich (Barcelona, Spain).
Mueller–Hinton broth (MHB), Brain Heart Infusion (BHI), Clostridium reinforced medium (CRM), Tryptone Soy Agar (TSA), and Sabouraud Dextrose Agar (SDA) were purchased from Oxoid (Basingstoke, UK). Beren (cosmetic diluent) was acquired from Scharlab (UK).
DMEM (Dulbecco’s Modified Eagle’s medium) was purchased from ThermoFisher, MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) from Sigma-Aldrich (St. Louis, MO, USA) and DMSO (99% dimethyl sulfoxide) from Sigma-Aldrich (Barcelona, Spain).
Mueller–Hinton broth (MHB), Brain Heart Infusion (BHI), Clostridium reinforced medium (CRM), Tryptone Soy Agar (TSA), and Sabouraud Dextrose Agar (SDA) were purchased from Oxoid (Basingstoke, UK). Beren (cosmetic diluent) was acquired from Scharlab (UK).
3
Pranoprofen Topical Formulation Development
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Pranoprofen (2-(5H-chromeno [2,3-bpyridin-7-yl) propanoic acid) was a kind gift from Alcon Cusi (Barcelona, Spain). Tween® 80 (Polyethylene glycol sorbitan monooleate) and Castor oil (Ricinus communis L.) were acquired from Sigma-Aldrich Química (Barcelona, Spain). Lanette® 18 (stearyl alcohol) was purchased from Cognis (Dusseldorf, Germany). PEG-8 Caprylic/Capric Glycerides (LAS) was received as a gift sample from Gattefosse (Saint-Priest, France). The tattoo ink (Viking-Ink BW Black Tribal, Náquera, Spain) was purchased from Viking-Ink B&W. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) utilized for cell viability was obtained from Invitrogen Alfagene® (Carcavelos, Portugal), and the HaCat was obtained by Cell Lines Service (CLS, Eppelheim, Germany). MilliQ water obtained by a MilliQ® Plus System lab and was used across formulations and all experiments. The phosphate buffer saline (PBS) tablets pH 7.4 were acquired from Sigma (Darmstadt, Germany) and prepared as according to the manufacturer’s instructions. All the other chemicals and reagents used in this investigation were of analytical grade.
4
In Vitro Skin Permeation Assay of Orobol
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Orobol (purity ≥ 98.0%) was provided from Wuhan ChemFaces Biochemical Co., Ltd. (Wuhan, China). Medium-chain glycerides (MCTs), refined cocoa butter, and shea butter were obtained from DAMY Chemical Co., Ltd. (Seoul, Korea). Capmul MCM EP was gifted by ABITEC Co. (Peterborough, UK). Labrafac CC, Labrasol (PEG-8 caprylic/capric glycerides), and Transcutol HP were gifted by Gattefossé Co. (Saint Priest, France). Miglyol was purchased from IOI Oleo GmbH (Hamburg, Germany). Tween 20 and sodium dodecyl sulfate (SDS) were obtained from Sigma-Aldrich Chemical Co. (St. Louis, MO, USA). Phosphate-buffered saline (PBS) was purchased from Lonza, Ltd. (Basel, Switzerland). Strat-MTM membranes (2.5 cm in diameter) were purchased from Merck Millipore (Billerica, MA, USA). High-performance liquid chromatography (HPLC)- grade methanol, acetonitrile, and water were purchased from Thermo Fisher Scientific Co. (Pittsburgh, PA, USA). Female human cadaver skin (2 × 2 cm2) was purchased from a skin and tissue bank (Hans Biomed Co., Seoul, Korea). Studies that use human cadaver skin from a tissue bank do not require approval from the Institutional Review Board (IRB) or ethics committee (Article 33, Enforcement Rule of the Bioethics and Safety Act in the Republic of Korea) [22 (link)].
5
Pranoprofen Topical Formulation Development
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Pranoprofen (CAS 52549-17-4) was acquired from Alcon Cusi (Barcelona, Spain). Castor oil (CAS 8001-79-4) (Ricinus communis L.) and Tween® 80 (CAS 9005-65-6) (Polyoxyethylene 20 sorbitan monooleate) were obtained from Sigma-Aldrich Química (Barcelona, Spain). Precirol® ATO 5 (CAS 8067-32-1) (Glyceryl Palmitostearate) and LAS (CAS 61791-29-5) (PEG-8 Caprylic/Capric Glycerides) were obtained from Gattefosse (Saint-Priest, France). Carbomer 940 (CAS 9003-01-4) (acrylic acid polymer) was purchased from Fagron ibérica (Barcelona, Spain). Sepigel 305® (CAS 64742-47-8) (Polyacrylamide, C13-14 Isoparaffin Laureth-7) was purchased from Acofarma (Barcelona, Spain). The purified water utilized in all experiments was collected from a MilliQ® Plus System (Darmstadt, Germany), lab-supplied. The tablets of phosphate-buffered saline (PBS) were acquired from Sigma-Aldrich Chemie (Steinheim, Germany) as well as processed as specified by the manufacturer and stored in fridge for further use. All other chemicals for analytical experiments and reagents utilized in the research were of analytical or high-performance liquid chromatography (HPLC) grade and acquired from Fisher Scientific (Leicestershire, UK).
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