To examine the bio-distribution of HA-PAAVB NPs in 4T1 tumor-bearing mice, the near-infrared fluorescent dye, DiR, was encapsulated into HA-PAAVB NPs. When the volume of the subcutaneous 4T1 tumor reached 200–300 mm3, eight mice were randomly divided into two groups. Free DiR and HA-PAAVB NPs/DiR were intravenously administrated into mice, respectively (the dosage of DiR was calculated as 0.35 mg per kg mouse). At pre-determined intervals (2, 4, 8, 10, and 24 h), the fluorescent images were captured using an in vivo imaging system (IVISs Lumina XR Series III, PerkinElmer). Then the mice were sacrificed and major tissues (heart, liver, spleen, lung, kidney, and tumor) were harvested for ex-vivo imaging.
Iviss lumina xr series 3
Manufactured by PerkinElmer
The IVISs Lumina XR Series III is a high-performance in vivo imaging system designed for preclinical research applications. It features advanced optical and imaging technologies to enable sensitive and quantitative detection of bioluminescent and fluorescent signals in small animal models.
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2 protocols using iviss lumina xr series 3
1
In vivo bio-distribution of HA-PAAVB NPs
2
Biodistribution of Nanobullets in 4T1 Tumor Mice
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To examine the biodistribution of nanobullets in 4T1 tumor-bearing mice, the near-infrared fluorescent dye, IR780, was encapsulated into HA-ACVA NBs and HA-ACVA-AZ NBs. Until the volume of the subcutaneous 4T1 tumor reached 200–300 mm3, mice were randomly divided into three groups. Free IR780, IR780@HA-ACVA NBs and IR780@HA-ACVA-AZ NBs were intravenously administrated into mice, respectively. (The dosage of IR780 was calculated as 0.3 mg per kg mouse.) At preset intervals (2, 4, 7, 10 and 24 h), the fluorescent images were captured using in vivo imaging system (IVISs Lumina XR Series III, PerkinElmer). Finally, the mice were sacrificed and major tissues (heart, liver, spleen, lung, kidney and tumor) were harvested for ex vivo imaging.
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