Salubrinal sal

Manufactured by Bio-Techne

Sourced in Switzerland

Salubrinal (SAL) is a small molecule that inhibits the dephosphorylation of eIF2α, a key regulatory subunit of the eukaryotic translation initiation complex. This inhibition leads to the attenuation of protein synthesis, which can have various cellular effects depending on the specific context and application.

Automatically generated - may contain errors

Lab products found in correlation

Melatonin mel, by Merck Group (2 mentions) Stf 083010, by Selleck Chemicals (2 mentions) Thapsigargin tha, by Enzo Life Sciences (2 mentions) Tunicamycin tun, by Enzo Life Sciences (2 mentions) Cobalt chloride cocl2, by Merck Group (1 mentions) Cobalt chloride, by Merck Group (1 mentions)

2 protocols using salubrinal sal

Induction and Inhibition of ER Stress

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Chemical hypoxia was induced with Cobalt Chloride (CoCl₂, Merck, Darmstadt, Germany).
ER stress was induced with HA15 (Selleckchem, Zurich, Switzerland), Thapsigargin (THA, Enzo LifeSciences, Lausen, Switzerland), or Tunicamycin (TUN, Enzo LifeSciences, Lausen, Switzerland).
ER stress was inhibited by 4-(2-aminoethyl) benzenesulfonyl fluoride hydrochloride (AEBSF; Sigma, Darmstadt, Germany), Melatonin (Mel; Sigma, Darmstadt, Germany), STF-083010 (STF; Selleckchem, Zurich, Switzerland), 4μ8C (Selleckchem, Zurich, Switzerland), GSK2656157 (GSK; Selleckchem, Zurich, Switzerland) or Salubrinal (SAL; Tocris Biosciences, Bristol, UK).

Yart L., Bastida-Ruiz D., Allard M., Dietrich P.Y., Petignat P, & Cohen M. (2022). Linking unfolded protein response to ovarian cancer cell fusion. BMC Cancer, 22, 622.

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Modulation of ER Stress Responses

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Chemical hypoxia was induced with Cobalt Chloride (CoCl 2 , Merck, Darmstadt, Germany).
ER stress was induced with HA15 (Selleckchem, Zurich, Switzerland), Thapsigargin (THA, Enzo LifeSciences, Lausen, Switzerland), or Tunicamycin (TUN, Enzo LifeSciences, Lausen, Switzerland). ER stress was inhibited by 4-(2-aminoethyl) benzenesulfonyl uoride hydrochloride (AEBSF; Sigma, Darmstadt, Germany), Melatonin (Mel; Sigma, Darmstadt, Germany), STF-083010 (STF; Selleckchem, Zurich, Switzerland), 4µ8C (Selleckchem, Zurich, Switzerland), GSK2656157 (GSK; Selleckchem, Zurich, Switzerland) or Salubrinal (SAL; Tocris Biosciences, Bristol, UK).

Yart L., Bastida-Ruiz D., Allard M., Dietrich P., Petignat P., & Cohen M. (2021). Linking Unfolded Protein Response to Ovarian Cancer Cell Fusion.

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