Isotretinoin (13-cis retinoic acid; Sigma R3255) was dissolved in DMSO and further diluted in corn oil (Sigma C8267). Mice were treated by oral gavage for 3 consecutive days with 1 mg of Isotretinoin in 10% DMSO/corn oil or 10% DMSO/corn oil (vehicle). Mice were sacrificed and the skin was analyzed.
Isotretinoin
Manufactured by Merck Group
Sourced in United States
Isotretinoin is a laboratory chemical compound used in research and development applications. It is a retinoid, a class of chemical compounds related to vitamin A. The core function of Isotretinoin is to serve as a research tool for studying cellular processes and the effects of retinoids on biological systems.
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3 protocols using isotretinoin
1
Topical Isotretinoin Treatment in Mice
2
Isotretinoin, Thalidomide, and DMSO Protocol
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Isotretinoin (catalog #4759-48-2, purity ≥98%), thalidomide (catalog #50-35-1, Purity ≥ 98%), and dimethyl sulfoxide (DMSO, catalog D8418) were purchased from Sigma-Aldrich (St. Louis, MO., USA).
3
Oral Administration of Teratogenic Drugs in Mice
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Isotretinoin, misoprostol, methotrexate, mifepristone and levonorgestrel were purchased from Sigma-Aldrich (St. Louis, MO, USA; Table I ). The test drugs were dissolved/suspended in 0.75% Tween-80 solution (Sigma-Aldrich), and dosing solutions were prepared daily prior to treatment. The application volume of the drugs was 10 ml/kg body weight and was calculated based on the most recently recorded body weight of each individual animal. The test mixture was administered daily by gavage to female mice for 3 days. Control mice received an equivalent volume of 0.75% Tween-80 solution alone. The oral administration method was selected for this study since these drugs are administered orally in a clinical setting.
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