We used different pharmacological inhibitors to determine the cell death mechanism of I-CRP in leukemic cells. QVD-OPh (QVD, 10 μM) as a general caspase inhibitor; Z-DEVD (1 μM) as caspase-3 inhibitor; Z-IETD (1 μM) as caspase-8 inhibitor; and Z-LEHD (1 μM) as caspase-9 inhibitor were acquired from BioVision (CA, USA). N-acetyl-cysteine (NAC, 5 mM) was used as an ROS inhibitor. The inhibitors were added 30 minutes before CC50 I-CRP treatment. All stock solutions were wrapped in foil and stored at −20°C.
Z devd
Manufactured by Abcam
Sourced in United States
Z-DEVD is a synthetic cell-permeable peptide that serves as a potent and selective inhibitor of caspase-3, a key executioner caspase involved in apoptosis. It functions by binding to the active site of caspase-3, thereby preventing its proteolytic activity.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using z devd
1
Exploring I-CRP-induced Leukemic Cell Death
2
Paclitaxel and Caspase Inhibitor Assay
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