4 nitroanisole

Manufactured by Merck Group

4-nitroanisole is a chemical compound used in various laboratory applications. It serves as a chemical intermediate and a precursor in the synthesis of other organic compounds. The core function of 4-nitroanisole is to facilitate specific chemical reactions and transformations within the laboratory setting. No further details or interpretation on its intended use are provided.

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Lab products found in correlation

2 protocols using 4 nitroanisole

Mutagenicity Assay Chemical Reagents

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Acetoin ≥95%, dimethyl carbonate 99%, p-toluenesulphonic acid monohydrate 98.5%, 4-methoxyacetophenone 99%, anhydrous anisole 99.7%, acetic anhydride ≥99%, anhydrous acetonitrile 99.8%, anhydrous cyclohexane 99.5%, anhydrous diethyl ether ≥99%, anhydrous propylene carbonate 99.7%, iron(iii) chloride 97%, anhydrous ethyl acetate 99.8%, anhydrous magnesium sulphate 99.5%, Nile red ≥98%, 4-nitroaniline ≥99%, 4-nitroanisole analytical standard, 4-nitrophenol spectrophotometric grade, 1,2-dimethylimidazole 98%, 1-bromodecane 98%, methanol 99.9%, dichloromethane 99.8%, acetone 99.9%, chloroform-d (CDCl₃, 99.8% D), chloroform 99.9%, dimethyl sulfoxide 99.9% were purchased from Sigma-Aldrich. Ames MPF 98/100 kits, 2-nitrofluorene and 4-nitroquinoline-N-oxide were purchased from Xenometrix. TA98 and TA100 were stored at −70 °C. QUANTOFIX® Peroxide 100 was purchased from Macherey-Nagel. N,N-Diethyl-4-nitroaniline was purchased from VWR.

Jin S., Byrne F.P., Clark J.H., McElroy C.R., Quinn A., Sherwood J, & Hunt A.J. (2021). 3-Methoxybutan-2-one as a sustainable bio-based alternative to chlorinated solvents. RSC Advances, 11(62), 39412-39419.

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Quantifying Xenobiotic Metabolism Inhibition

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All chemicals used in this study were ACS grade or higher. Unless otherwise specified, all chemicals and reagents were purchased from Sigma-Aldrich (St. Louis, MO). In particular, 4-nitrophenol (substrate), 4-nitrocatechol (product), 4-nitroanisole (internal standard), 1,3-butadiene metabolites (3,4-epoxy-1-butene, 1,2:3,4-diepoxybutane, 3-butene-1,2-diol), inhibitors styrene, styrene oxide, propylene oxide, caffeine, aniline, dimethylnitrosamine, chlorzoxazone, Fomepizole (4-methylpyrazole), toluene, and phenethyl isothiocyanate were purchased from Sigma-Aldrich. The inhibitors 1,2-butanediol, 1,4-butanediol, and 1,2,4-butanetriol were purchased from Fisher Scientific. Pooled human liver microsomes (HLM150s) and human recombinant CYP2E1 (supersomes) co-expressed with cytochrome b₅ were purchased from BD Biosciences (San Jose, CA).

Hartman J.H., Miller G.P, & Boysen G. (2014). Inhibitory Potency of 4-Carbon Alkanes and Alkenes toward CYP2E1 Activity. Toxicology, 318, 51-58.

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