Given the linear PK of quizartinib, predictions of PK parameters, including steady‐state Cmax (Cmax,ss), AUC from time 0 to the end of the dosing interval (AUCτ) and Tmax at steady‐state (Tmax,ss), were simulated by superpositioning using Phoenix 6.3 (Certara USA, Inc., Princeton, NJ, USA). Statistical analysis and determination of drug–drug interaction for predicted PK parameters, AUCτ and Cmax,ss, were performed as described above for exposure parameters (AUCinf, AUClast, Cmax).
Phoenix 6
Manufactured by Certara
Sourced in United States
Phoenix 6.3 is a software tool used for pharmacokinetic and pharmacodynamic modeling and simulation. It provides a platform for analyzing and interpreting data related to the absorption, distribution, metabolism, and elimination of drugs in the body.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using phoenix 6
1
Simulation of Quizartinib Pharmacokinetics
2
Pharmacokinetic Analysis of Drug Exposure
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Non compartmental pharmacokinetic analysis was performed using Phoenix 6.3 (Certara, St Louis, MO, USA) to determine the following pharmacokinetic parameters; area under the plasma concentration time curve (AUC), maximum plasma concentration (Cmax), time to reach Cmax (Tmax), plasma clearance (CLp), steady state volume of distribution (Vss), elimination half-life of plasma concentration (t1/2), mean residence time of plasma concentration (MRT) and oral bioavailability (% F). Amount excreted in urine (Ae) was calculated from measured urine concentrations and volumes.
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