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90 protocols using mr750 3t scanner

1

3T fMRI Acquisition and Preprocessing

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fMRI data were acquired on a GE MR750 3T scanner using an 8-channel headcoil. T1-weighted anatomic images were acquired with a MP-RAGE sequence [matrix = 256 × 256, 156 axial slices, repetition time/echo time/flip angle (TR/TE/FA) = 8.2 ms/3.2 ms/12°, field of view (FOV) = 25.6 cm, final resolution = 1 × 1 × 1 mm]. Echo planar imaging (EPI) sequences used to collect the functional images used the following parameters: TR/TE/FA = 2000 ms/25 ms/60°, FOV = 24 cm, matrix = 64 × 64, 40 sagittal slices, slice thickness = 4 mm, original resolution was 4 × 3.75 × 3.75 mm, and images were resampled to a final isotropic 3 × 3 × 3 mm.
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2

High-Resolution Brain MRI Acquisition

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Images were acquired in a General Electrics Discovery MR750 3 T scanner. fast‐spoiled gradient echo pulse sequence, in a sagittal orientation. TR = 6.7 ms, TE = 3.0 ms, matrix size 256 × 256 mm2, flip angle 8°, FOV = 230 mm, acquisition time = 4′16″, 200 slices, voxel size 0.89 × 0.89 × 0.9 mm3.
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3

High-Resolution Diffusion Tensor Imaging

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Each participant was scanned using one of the two identical research-dedicated GE MR750 3T scanner equipped with high-power high-duty-cycle 50-mT/m gradients at 200 T/m/s slew rate, and an eight-channel head coil for parallel imaging at high bandwidth up to 1 MHz at the Duke-UNC Brain Imaging and Analysis Center. Following an ASSET calibration scan, diffusion-weighted images were acquired across two consecutive 2-min 50-s providing full brain coverage with 2 mm isotropic resolution and 15 diffusion-weighted directions (echo time (TE) = 84.9 ms, repetition time (TR) = 10,000 ms, b value = 1000 s/mm2, field of view (FOV) = 240 mm, flip angle = 90°, matrix = 128 × 128, slice thickness = 2 mm. High-resolution anatomical T1-weighted MRI data were obtained using a 3D Ax FSPGR BRAVO sequence (TE = 3.22 ms, TR = 8.148 ms, FOV = 240 mm, flip angle = 12°, 162 sagittal slices, matrix = 256 ×  256, slice thickness = 1 mm with no gap).
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4

High-Resolution fMRI Acquisition Protocol

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Participants were scanned using a research-dedicated GE MR750 3T scanner equipped with high-power high-duty-cycle 50-mT/m gradients at 200 T/m/s slew rate, and an eight-channel head coil for parallel imaging at high bandwidth up to 1 MHz at the Duke-UNC Brain Imaging and Analysis Center. A semi-automated high-order shimming program was used to ensure global field homogeneity. A series of 34 interleaved axial functional slices aligned with the anterior commissure-posterior commissure (AC-PC) plane were acquired for full-brain coverage using an inverse-spiral pulse sequence to reduce susceptibility artifact [TR/TE/flip angle = 2000 ms/30 ms/60; FOV = 240 mm; 3.75 × 3.75 × 4 mm voxels (selected to provide whole brain coverage while maintaining adequate signal-to-noise and optimizing acquisition times); interslice skip = 0]. Four initial RF excitations were performed (and discarded) to achieve steady-state equilibrium. To allow for spatial registration of each participant's data to a standard coordinate system, high-resolution three-dimensional structural images were acquired in 34 axial slices co-planar with the functional scans (TR/TE/flip angle = 7.7 s/3.0 ms/12; voxel size = 0.9 × 0.9 × 4 mm; FOV = 240 mm, interslice skip = 0).
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5

High-Resolution MRI Acquisition Protocol

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Each participant was scanned using a research-dedicated GE MR750 3T scanner equipped with high-power high-duty-cycle 50-mT/m gradients at 200 T/m/s slew rate, and an eight-channel head coil for parallel imaging at high bandwidth up to 1 MHz at the Duke-UNC Brain Imaging and Analysis Center. A semi-automated high-order shimming program was used to ensure global field homogeneity. A series of 34 interleaved axial functional slices aligned with the anterior commissure-posterior commissure (AC-PC) plane were acquired for full-brain coverage using an inverse-spiral pulse sequence to reduce susceptibility artifact (TR/TE/flip angle = 2000 ms/30 ms/60; FOV = 240 mm; 3.75 × 3.75 × 4 mm voxels; interslice skip = 0). Four initial RF excitations were performed (and discarded) to achieve steady-state equilibrium. To allow for spatial registration of each participant’s data to a standard coordinate system, high-resolution three-dimensional structural images were acquired in 34 axial slices co-planar with the functional scans (TR/TE/flip angle = 7.7 s/3.0 ms/12; voxel size = 0.9 × 0.9 × 4 mm; FOV = 240 mm, interslice skip = 0).
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6

fMRI Scanning and Skin Conductance Response Protocol

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fMRI scanning occurred concurrently with SCR-recording during the fear conditioning task; we report scan parameters for the purpose of reporting noise variables which may contribute to artifacts. At the Arkansas site, fMRI data were acquired on a Philips Achieva 3T X-series scanner using a 32-channel headcoil. Echo planar imaging sequences were used to collect the functional images using the following sequence parameters: TR/TE/FA = 2000 ms/30 ms/90°, FOV = 240 × 240 mm, matrix = 80 × 80, 37 axial slices (parallel to AC–PC plane to minimize OFC signal artifact), slice thickness = 2.5 mm, and final resolution of 3 × 3 × 3 mm.
At the UW-Madison site, fMRI data were acquired on a GE MR750 3T scanner using an 8-channel headcoil. EPI sequences used to collect the functional images used the following parameters: TR/TE/FA = 2000ms/ 25 ms/ 60°, FOV = 24 cm, matrix = 64 × 64, 40 sagittal slices, slice thickness = 4 mm, original resolution was 4 × 3.75 × 3.75 mm.
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7

Validation of ΔMSE-RSFC-based Volume Censoring

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To validate ΔMSE-RSFC-based optimization of volume censoring parameters (see Section 3.2.2.2), we employed a sample of resting state data acquired from 26 healthy participants (8 female, 18 male, mean age = 33.58) using a General Electric (GE; Boston, MA) MR750 3T scanner (multiband factor 6, TR = 850 ms, voxel size = 2 mm isotropic) at the New York State Psychiatric Institute (NYSPI; New York, NY), over 4 runs of 15 minutes each. Further details of this dataset are provided in the Supplementary Section S1.1.2, with demographic information shown in Table S1.
All procedures associated with the collection of the NYSPI dataset were approved by the New York State Psychiatric Institute Institutional Review Board. Written informed consent was obtained from each participant prior to their entering into the study. Participants were compensated monetarily for their participation.
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8

Multi-Echo Resting State fMRI

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Data were acquired on a GE MR750 3T scanner using a 32-channel GE receive-only head coil (Waukesha, WI). Each imaging session first involved acquiring a whole-brain anatomical MPRAGE scan with 1mm isotropic resolution. The resting state fMRI scan was 10 min long and involved acquisition with multi-echo time course EPI using the following parameters: 240mm field of view (FOV), 64×64 matrix size yielding 3.75mm isotropic resolution, in-plane SENSE acceleration factor 2, flip angle (FA)=77 degrees, repetition time (TR)=2.0s, and echo times (TEs)=12.8,28,43ms. The multi-echo fMRI sequence utilized vendor EPI excitation and a modified EPI readout, and utilized online reconstruction. Each TR resulted in the acquisition of 3 volumes, one for each TE. These volumes are rearranged to yield one volumetric time series dataset for each TE.
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9

Multimodal Neuroimaging of Hippocampal Subfields

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During visit 2, MRI data were obtained from 59/78 individuals who completed visit 1. Of the other 19 individuals, 4 dropped out prior to visit 2; 5 declined the MRI scan due to claustrophobia during a simulated scan; 2 failed MRI safety screening on the day of the scan; and 8 were unable to complete MRI visits due to the COVID-19 pandemic.
MRI data were acquired on a GE MR750 3 T scanner with a 32-channel Nova Medical coil using parallel imaging. MPnRAGE (Kecskemeti et al., 2016 (link)) with retrospective motion correction was used to obtain motion-corrected, 1.0 mm isotropic T1-weighted images (TR = 4.9 ms, TE = 1.8 ms, flip angles = 4°/8° [first 304/remaining 82 views], 200 axial slices, acquisition time = 9:01). We used a modified version of the “high-resolution in-plane thick-slab” approach described previously (Ekstrom et al., 2009 (link); Yushkevich et al., 2015b (link)) to acquire a T2-weighted sequence, with oblique coronal images spanning the length of the hippocampus (TR = 7200 ms, TE = 76 ms, flip angle = 150°, 30 slices, 0.4 mm × 0.4 mm in-plane, 2.0 mm slice thickness, acquisition time = 6:29). Because anatomical changes unfold slowly along the long axis relative to other axes, this approach allows for the identification of distinct hippocampal subfields with a relatively brief acquisition time.
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10

T1-Weighted MRI Acquisition Protocol

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Data set 2 is the publicly available data set described in Maclaren, Han, Vos, Fischbein, and Bammer (2014). They acquired the data set with the approval of the Stanford University Institutional Review Board and all subjects gave their written informed consent.
A total of 120 T1‐weighted images were acquired from three healthy subjects (40 scans/subject). Each subject was scanned two times on 20 different days within a 31‐day period. Subjects were repositioned on the scanner console between the two scans in each session, so that all scans were treated as separate measurements (with a resulting break of ~5 min between scans). All images are acquired on the GE MR750 3T scanner using the ADNI‐recommended T1‐weighted imaging protocol for this system (accelerated sagittal 3D IR‐SPGR, standard 8‐channel phased array head coil, TR 7.3 ms, TE 3 ms, TI 400 ms, FA 11°, 256 × 256 matrix slice, 270 mm FOV, 1.2 mm slice thickness, acquisition time: 5 min 37 s).
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