Opegan hi

Manufactured by Santen

Sourced in Japan

Opegan Hi is a sterile, ophthalmic viscosurgical device (OVD) used during ophthalmic surgical procedures. It is a clear, colorless, highly viscous solution composed of sodium hyaluronate.

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Lab products found in correlation

Opegan, by Santen (1 mentions) Ha powder, by Seikagaku (1 mentions) Opegan hi, by Seikagaku (1 mentions) Discovisc, by Alcon (1 mentions) Viscoat, by Alcon (1 mentions) Infiniti vision system, by Alcon (1 mentions)

4 protocols using opegan hi

Comparative Analysis of Ophthalmic Viscosurgical Devices

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Table 2 shows the OVDs used in this study. Opegan^®, Opegan-Hi^®, and Shellgan^® were purchased from Santen Pharmaceutical Co., Ltd (Osaka, Japan). Opelead^® was purchased from Senju Pharmaceutical Co., Ltd (Osaka, Japan). These four products are distributed in Japan. Viscoat^® and Discovisc^® were purchased from Alcon Inc. (Hünenberg, Switzerland), which are distributed worldwide. A 3% hyaluronic acid (HA) solution was prepared by dissolving HA powder (derived from chicken combs, Seikagaku Corp., Tokyo, Japan) in phosphate buffered saline at a final concentration of 3%.Table 2

OVD products investigated in this study

Bland name	Composition	Distributor	Mw (kDa)		Classification [1 (link)]	Apparent viscosity (Pa s)
Bland name	Composition	Distributor	HA	CS	Classification [1 (link)]	Apparent viscosity (Pa s)
Opegan	1% HA with low Mw	Santen	1100	–	Very low viscosity dispersive	5.1
Opelead	1% HA with medium Mw	Senju	1700	–	Medium viscosity dispersive	34.6
3% HA	3% HA with low Mw	Homemade	700	–	Unreported	35.2
Viscoat	3% HA and 4% CS	Alcon	700	20	Medium viscosity dispersive	61.7
Shellgan	3% HA and 4% CS	Santen	700	50	Medium viscosity dispersive	73.0
Discovisc	1.65% HA and 4% CS	Alcon	1600	20	Viscous dispersive	117.0
Opegan-Hi	1% HA with high Mw	Santen	2500	–	Viscous cohesive	62.7

Molecular weights (Mw) of HA and chondroitin sulfate (CS) and apparent viscosity of OVDs at shear rate 1 (1/s) have already been determined [14 (link), 15 (link)]

Watanabe I., Hoshi H., Suzuki K., Nagata M, & Matsushima H. (2020). Quantitative Assessment of Ophthalmic Viscosurgical Devices on Visibility, Spreadability, and Durability as Corneal Wetting Agents for the Wet Shell Technique. Ophthalmology and Therapy, 9(3), 609-623.

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Microhook-assisted Trabeculotomy through Corneal Side Ports

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The surgery was performed through two corneal side ports.11 (link),12 (link) A spatula-shaped microhook designed specifically for use during μLOT was used (M-2215; Inami). Viscoelastic material (1% sodium hyaluronate; Opegan Hi; Santen Pharmaceutical) was injected into the anterior chamber through the clear corneal ports created using a 20-gauge micro-vitreoretinal knife (Mani) at the 2–3 and 9–10 o’clock positions. A microhook was inserted into the anterior chamber through the corneal port using a Swan-Jacob gonioprism lens (Ocular Instruments, Bellevue, WA, USA) to observe the angle opposite to the corneal port. The tip of the microhook was then inserted into Schlemm’s canal and moved circumferentially to incise the inner wall of Schlemm’s canal and trabecular meshwork over 3 clock hours. Using the same procedure, trabeculotomy was performed in the opposite angle using a microhook inserted through the other corneal port. The trabeculotomy extended about two-thirds of the circumference. After the viscoelastic material was aspirated bimanually, the corneal ports were closed by corneal stromal hydration.

Tanito M., Matsuzaki Y., Ikeda Y, & Fujihara E. (2017). Comparison of surgically induced astigmatism following different glaucoma operations. Clinical Ophthalmology (Auckland, N.Z.), 11, 2113-2120.

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Schlemm's Canal Excision with Phacoemulsification

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All surgeries were performed by experienced glaucoma specialists, and the surgical procedures were as previously described [15 (link)]. Standard phacoemulsification was performed with implantation of an intraocular lens through a clear 2.4-mm temporal corneal incision using topical anesthesia. The patient’s head and the microscope were tilted to visualize the nasal angle with a gonioprism. The surgeon then filled the anterior chamber with additional viscoelastic material (1% sodium hyaluronate, Opegan Hi, Santen Pharmaceutical, Osaka, Japan). Next, the tip of the KDB was inserted into the Schlemm’s canal and moved circumferentially to excise the trabecular meshwork over 3–4 clock hours. Finally, the viscoelastic material was removed, and the anterior chamber was filled with a balanced saline solution.

Iwasaki K., Kakimoto H., Orii Y., Arimura S., Takamura Y, & Inatani M. (2022). Long-Term Outcomes of a Kahook Dual Blade Procedure Combined with Phacoemulsification in Japanese Patients with Open-Angle Glaucoma. Journal of Clinical Medicine, 11(5), 1354.

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Evaluation of IOL Insertion Contamination

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Water-based red ink was mixed with the OVD (Opegan Hi®, Santen; Osaka, Japan) to create a colored OVD. The Opegan Hi is purified sodium hyaluronate with a molecular weight of 250 × 10³ Da, and is a commonly used OVD in Japan. Each type of injector was equipped with an OVD and IOL, and a 2 mm length from the tip of cartridge was subsequently replaced with the colored OVD. This enabled us to recreate and visually verify the conditions under which the injector tips were contaminated in the surgical field during IOL insertion with injectors. Lens removal was performed using normal ultrasonic surgery by placing a 2.7 mm, 2.5 mm, or 2.2 mm incision into an excised porcine eye. The Infiniti® vision system (Alcon, Fort Worth, TX, USA) was used to remove the lens. The anterior chamber was filled with the OVD, and the IOL was inserted using an injector after adjusting the intraocular pressure to approximately 15–20 mmHg using a Schiotz tonometer. The various combinations of IOLs (Figure 1) and injectors used in this study were: a three-piece shaped IOL, VA60BBR + TypeE1 (HOYA incision size 2.5 mm; group A, n=5); a single-piece IOL, 251+ iSert micro, preloaded (HOYA incision size 2.2 mm; group G, n=5); and a single-piece IOL, SN6CWS preloaded (Alcon, incision size 2.7 mm; group C, n=5).

Matsuura K, & Inoue Y. (2014). Ophthalmic viscosurgical device backflow into cartridge during intraocular lens insertion using injectors. Clinical Ophthalmology (Auckland, N.Z.), 8, 321-325.

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