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Millennium 120

Manufactured by Agilent Technologies
Sourced in United States

The Millennium 120 is a high-performance liquid chromatography (HPLC) system manufactured by Agilent Technologies. It is designed for efficient and reliable separation and analysis of a wide range of compounds. The Millennium 120 system provides precise control of flow rates, temperature, and other parameters to ensure accurate and reproducible results.

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3 protocols using millennium 120

1

Radiotherapy Dose Calculation Comparison

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Plans were created for a 6-MV photon beam with a Millennium 120 multileaf collimator using 7 to 13 noncoplanar treatment fields in the Eclipse TPS (Varian Medical Systems). We used extended CT in all cases. The plans were then optimized for clinical acceptability, calculated using AXB Dw, and normalized so that 95% of the PTV received the prescribed dose, allowing for doses of up to 125%.
Several versions of the algorithm were used between 2012 and 2017. For our study, we recalculated the doses with version 13.0.26 of AAA and AXB (Dw and Dm) for the same number of monitor units as the original plan and with identical beam and multileaf collimator setup. Calculation grid resolution was set to 2 mm in all cases, as recommended in the literature.3 ,5 (link),7 (link) An important aspect of our study concerns the change introduced with AXB v11 regarding the determination of tissue types from CT images.32 The version of AXB used in our study could produce different results than those previously obtained in studies that used v10.7 (link), 8 , 9 ,21 (link),25 (link),26 (link),30 (link)
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2

Photon Beam Characterization for Clinac iX

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Data were acquired using Clinac iX (Varian Medical Systems, Palo Alto, California, USA) equipped with the Millennium 120 leaf MLC. The beam energy and dose rates of photon beam available at our hospital were 100, 150, 200, and 250 monitor unit (MU)/min in 4 MV and 100, 200, 300, 400, 500, and 600 MU/min in 10 MV.
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3

VIPER Software for 3D Dose Verification

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The VIPER software was developed at the Calvary Mater Newcastle Hospital (CMNH) for EP-ID-based 3D dose distribution reconstruction onto a virtual water phantom [25 (link), 26 (link)]. VIPER can be used for either 2D or 3D dose reconstruction to perform dosimetric verification of the individual fields or composite plan, respectively. However, it was shown by Kruse that single field planar verification is insensitive and not sufficient to detect important dosimetric inaccuracies of the overall IMRT plan [27 (link)]. Therefore, 3D reconstructed dose-based verification is better than using 2D reconstructed doses. The resulting 3D dose can be compared with the corresponding dose distribution computed by a treatment planning system (TPS) to be evaluated.
Instructions provided by CMNH were followed to obtain a VIPER (v. 3.10 beta, May 2019) calibration tailored to our facility. VIPER was configured for 6 MV beams from a Varian CLINAC 2100 CD linac (Varian Medical Systems, Palo Alto, CA), equipped with the Millennium 120 multileaf collimator (MLC) and the PortalVision aS500 EPID. Repetition rate of 600 monitor units per minute was used.
The validation and feasibility of VIPER for SRS plan verification were described by our group in a recent publication [24 (link)].
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