Kainate ka

Manufactured by Merck Group

Sourced in United Kingdom, Italy

Kainate (KA) is a chemical compound used in various laboratory applications. It is a potent agonist of kainate receptors, a type of ionotropic glutamate receptor. Kainate is commonly used as a tool in neuroscience research to study the structure and function of these receptors, as well as their role in neurological processes.

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Lab products found in correlation

D ap5, by Merck Group (1 mentions) Victoza, by Novo Nordisk (1 mentions)

2 protocols using kainate ka

Methamphetamine Addiction Pathway Study

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Methamphetamine was purchased from the National Institute for Food and Drug Control (Beijing, China). The selective DR1 antagonist SCH23390, DR2 antagonist raclopride, the mitogen-activated protein kinase inhibitor U0126 and the PI3K inhibitor wortmannin were purchased from Tocris Cookson Ltd. (Bristol, United Kingdom). The Akt/PKB inhibitor triciribine PKA inhibitor H89, NMDAR antagonist D-AP5 and the kainate receptor agonist kainate (KA) were obtained from Sigma-Aldrich (United Kingdom).
Stock solutions, at thousand times the final concentration, were made up in water or in DMSO, and stored in individual aliquots at −20°C. Final solutions were prepared freshly on the day of the experiment.

Li Y., Xie X., Xing H., Yuan X., Wang Y., Jin Y., Wang J., Vreugdenhil M., Zhao Y., Zhang R, & Lu C. (2019). The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices. Frontiers in Cellular Neuroscience, 13, 277.

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Rodent Models of Neurological Disorders

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LIR (Victoza; Novo Nordisk S.p.A., Rome, Italy; pre-filled pen containing 18 mg liraglutide in 3 ml) was diluted in saline solution (0.9% NaCl) to obtain a final solution of 300 µg/ml and subcutaneously (s.c.) administered at a dose of 300 µg/kg/day in WAG/Rij rats. Instead for C57BL/6 mice, pre-filled pen containing LIR was diluted in saline solution (0.9% NaCl) to obtain a final solution of 300 g/10 ml and administered s.c. at the dose of 300 g/kg/day. Kainate (KA; Sigma Aldrich Milan, Italy) was dissolved in saline (50 nl, 0.2 μg) and injected intrahippocampally (unilateral) at a volume of 0.5 l (see below).

Citraro R., Iannone M., Leo A., De Caro C., Nesci V., Tallarico M., Abdalla K., Palma E., Arturi F., De Sarro G., Constanti A, & Russo E. (2019). Evaluation of the effects of liraglutide on the development of epilepsy and behavioural alterations in two animal models of epileptogenesis. Brain research bulletin, 153.

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