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Tripelennamine hydrochloride

Manufactured by Merck Group
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Sourced in Japan, United Kingdom

Tripelennamine hydrochloride is a chemical compound used in laboratory and research settings. It is a white, crystalline powder that is soluble in water and other polar solvents. The primary function of tripelennamine hydrochloride is as a reagent and intermediate in chemical synthesis and analysis.

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Lab products found in correlation

Pyrilamine maleate, by Merck Group (1 mentions) Ranitidine hydrochloride, by Merck Group (1 mentions) 14c leucine, by PerkinElmer (1 mentions) Epinastine hydrochloride, by Merck Group (1 mentions) Indomethacin, by Merck Group (1 mentions) Tetrodotoxin, by Fujifilm (1 mentions) Acetylcholine chloride, by Merck Group (1 mentions) Imidazole, by Fujifilm (1 mentions) Atropine sulfate salt monohydrate, by Merck Group (1 mentions) Cremophor el, by Nacalai Tesque (1 mentions) Hemicholinium 3, by Merck Group (1 mentions) Eserine, by Merck Group (1 mentions) Fura 2 am, by Dojindo Laboratories (1 mentions) Dimethyl sulfoxide d6, by Merck Group (1 mentions) Quinolone, by Merck Group (1 mentions) Methanol, by Merck Group (1 mentions) Acetonitrile, by Merck Group (1 mentions) Methanol d4, by Merck Group (1 mentions) Formic acid, by Merck Group (1 mentions)

Spelling variants of this product

Hydrochlorides (2 citations)

3 protocols using tripelennamine hydrochloride

1

Histamine Receptor Binding Assay

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The specific HRH1 antagonist [3H]pyrilamine was used in saturation and competitive binding experiments, at 20.0 Ci/mmol (Perkin-Elmer, Waltham, MA, United States), to label histamine receptors. The synthesis of protein labeled with carbon fourteen (14C) was produced using [14C]leucine (20.0 Ci/nmol) (Perkin-Elmer, Waltham, MA, United States). The following drugs were used as cold competitors: doxepin hydrochloride (Wako, Osaka, Japan), epinastine hydrochloride (Sigma–Aldrich, St. Louis, MO, United States), pyrilamine maleate (Sigma–Aldrich, St. Louis, MO, United States), ranitidine hydrochloride (Sigma–Aldrich, St. Louis, MO, United States), thioperamide (R&D Systems, Minneapolis, MN, United States), and alpha-methylhistamine (Sigma–Aldrich, St. Louis, MO, United States). Tripelennamine hydrochloride (pyribenzamine; Sigma–Aldrich, St. Louis, MO, United States) stabilized the HRH1 during the synthesis reaction.
Suzuki Y., Ogasawara T., Tanaka Y., Takeda H., Sawasaki T., Mogi M., Liu S, & Maeyama K. (2018). Functional G-Protein-Coupled Receptor (GPCR) Synthesis: The Pharmacological Analysis of Human Histamine H1 Receptor (HRH1) Synthesized by a Wheat Germ Cell-Free Protein Synthesis System Combined with Asolectin Glycerosomes. Frontiers in Pharmacology, 9, 38.
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2

Measuring Neuronal Calcium Dynamics

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Chemicals used were imidazole, tetrodotoxin (Wako Pure Chemical, Osaka, Japan), atropine
sulfate salt monohydrate, tripelennamine hydrochloride, indomethacin, hemicholinium-3,
acetylcholine chloride, eserine (Sigma-Aldrich, St. Louis, MI, U.S.A.), fura2/AM (Dojindo
Laboratories, Kumamoto, Japan), and cremophor EL (Nacalai Tesque, Kyoto, Japan).
KANEDA T., KANDA H., TAJIMA T., URAKAWA N, & SHIMIZU K. (2017). Imidazole-induced contractions in bovine tracheal smooth muscle are not dependent on the cAMP pathway. The Journal of Veterinary Medical Science, 80(2), 341-345.
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3

Analysis of Seized Synthetic Cannabinoids

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Samples were test-purchased online from "legalhighs" websites prior to the 26 May 2016 UK blanket NPS ban. A set of e-liquid samples (6 brands, 9 samples) was also test-purchased from online retailers, prior to the ban. All had been sold as cannabinoid-containing mixtures, although the exact cannabinoid compound quoted varied between mixtures or, in some cases, was not disclosed. Three powder samples were supplied by TICTAC Communications Ltd. from street seizures. Finally, three blank A4 sheets of cannabinoid sprayed/impregnated blotting paper ("blotting paper 01-03") were obtained from an online retailer, the material was not accompanied by any specification about the type of drugs or their amounts. Samples were kept in a locked cabinet at room temperature prior to analysis. Methanol, acetonitrile, water, formic acid (FA) and trifluoroacetic acid (TFA), HPLC grade, dimethyl sulfoxide-d6, isotopic purity 99.9 atom %D, Methanol-d4, isotopic purity 99.8 atom %D, t-butylmethyl-ether (TBME), tripelennamine hydrochloride, and quinolone were all from Sigma-Aldrich (Dorset, UK).
Apirakkan O., Frinculescu A., Denton H., Shine T., Cowan D., Abbate V., & Frascione N. (2020). Isolation, detection and identification of synthetic cannabinoids in alternative formulations or dosage forms. Forensic Chemistry, 18, 100227-100227.
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