400k array

Manufactured by Agilent Technologies

Sourced in United States

The 2 × 400K array is a high-resolution microarray platform designed for genomic analysis. The array features two identical arrays on a single slide, each containing approximately 400,000 probes targeting the human genome. This provides researchers with increased statistical power and the ability to perform replicate experiments on a single sample.

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Lab products found in correlation

Agilent genomic workbench 7, by Agilent Technologies (1 mentions)

Spelling variants of this product

GenetiSure Cancer Research array CGH + SNP (2 × 400k) (2 citations) 2×400K array platform (2 citations)

2 protocols using 400k array

Rare CNV Detection in CHD8 Gene

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To confirm rare CNVs in CHD8, we utilized a custom Agilent 8 × 60K CGH array with 150 bp probe spacing across the gene body of CHD8 and predicted neighboring regulatory elements. In addition, large genomic CNVs were identified using a previously described Agilent 2 × 400K array (Girirajan et al., 2013 (link)).

Bernier R., Golzio C., Xiong B., Stessman H., Coe B.P., Penn O., Witherspoon K., Gerdts J., Baker C., Vulto-van Silfhout A.T., Schuurs-Hoeijmakers J.H., Fichera M., Bosco P., Buono S., Alberti A., Failla P., Peeters H., Steyaert J., Vissers L.E., Francescatto L., Mefford H.C., Rosenfeld J.A., Bakken T., O’Roak B.J., Pawlus M., Moon R., Shendure J., Amaral D.G., Lein E., Rankin J., Romano C., de Vries B.B., Katsanis N, & Eichler E.E. (2014). Disruptive CHD8 mutations define a subtype of autism early in development. Cell, 158(2), 263-276.

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Customized Array-Based CNV Analysis

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Copy number variants (CNVs) were tested with a customized 2 × 400K array (Agilent Technologies, Santa Clara, CA, USA) with genomewide coverage and enriched probes in >300 genes linked to skeletal disease, as described.⁽²⁶⁾ On average, the array covers targeted gene areas with one probe per 100 base pairs (bp) in coding regions and one per 500 in introns and untranslated regions (UTRs). We performed the tests with standard procedures and analyzed results with Agilent Genomic Workbench 7.0 (Agilent Technologies).

Mäkitie R.E., Henning P., Jiu Y., Kämpe A., Kogan K., Costantini A., Välimäki V., Medina‐Gomez C., Pekkinen M., Salusky I.B., Schalin‐Jäntti C., Haanpää M.K., Rivadeneira F., Bassett J.H., Williams G.R., Lerner U.H., Pereira R.C., Lappalainen P, & Mäkitie O. (2021). An ARHGAP25 variant links aberrant Rac1 function to early‐onset skeletal fragility. JBMR Plus, 5(7), e10509.

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